Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Journal Year: 2024, Volume and Issue: 1867(4), P. 195051 - 195051
Published: Aug. 8, 2024
Language: Английский
Open Life Sciences, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 1, 2025
Gliomas can cause nerve cancer-related death, and surgical removal be challenging. Convallatoxin functioned as anti-proliferation anti-angiogenesis in cancer cells. However, convallatoxin's effect on glioma remains unclear. The aim of this study is to investigate the convallatoxin proliferation angiogenesis cells, explore underlying mechanism. Human cell lines U251MG A172 were treated with 12.5, 25, 50 nM convallatoxin. Cell was investigated using CCK-8 assay colony formation assay. Migration invasion analyzed transwell assays. Angiogenesis evaluated a tube phosphorylation Janus kinase (JAK) signal transducer activator transcription 3 (STAT3) measured Western blots. A xenotransplantation model nude mice used progression. In dose-dependently reduced viability formation. suppressed migration invasion. Similarly, convallatoxin-treated cells had weakened angiogenesis. downregulated JAK STAT3 levels. also inhibited progression models. By inhibiting JAK/STAT3 signaling pathway, proliferation, migration, invasion, proving promising therapeutic candidate for gliomas.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 29, 2024
Tripartite-motif 56 (TRIM56) is a member of the TRIM family, and was shown to be an interferon-inducible E3 ubiquitin ligase that can overexpressed upon stimulation with double-stranded DNA regulate stimulator interferon genes (STING) produce type I thus mediate innate immune responses. Its role in tumors remains unclear. In this study, we investigated relationship between expression TRIM56 gene its prognostic value pan-cancer, identifying as adverse factor glioma patients. Therefore, selected primary focus our investigation. We explored differential various subtypes verified independent gliomas. Our research revealed associated malignant biological behaviors gliomas, such proliferation, migration, invasion. Additionally, it M2 polarization macrophages The results were validated vitro vivo. Furthermore, utilized single-cell analysis investigate impact on cell communication cells non-tumor cells. constructed multi-gene signature based markers tumor high enhance prediction cancer patient prognosis. conclusion, study demonstrates serves reliable immune-related biomarker glioma.
Language: Английский
Citations
3
Medical Oncology, Journal Year: 2024, Volume and Issue: 41(8)
Published: June 25, 2024
Abstract Glioblastoma (GBM) is the most common malignant brain tumor, which, despite significant progress made in last years field of neuro-oncology, remains an incurable disease. GBM has a poor prognosis with median survival 12–15 months, and its aggressive clinical course related to rapid growth, extensive infiltration adjacent tissues, resistance chemotherapy, radiotherapy immunotherapy, frequent relapse. Currently, several molecular biomarkers are used practice predict patient response treatment. However, due overall unsatisfactory efficacy standard multimodal treatment remaining prognosis, there urgent need for new therapeutic strategies GBM. Recent evidence suggests that tumorigenesis associated crosstalk between cancer, immune stromal cells mediated by various cytokines. One key factors involved this process appears be interleukin-17 (IL-17), pro-inflammatory cytokine significantly upregulated serum tissue patients. IL-17 plays role tumorigenesis, angiogenesis, recurrence activating pro-oncogenic signaling pathways promoting cell survival, proliferation, invasion. facilitates immunomodulation tumor microenvironment secretion. In article we review latest scientific reports provide update on microenvironment, diagnosis,
Language: Английский
Citations
2
Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 1, 2024
With the gradual understanding of glioma development and immune microenvironment, many cells have been discovered. Despite growing comprehension cell functions clinical application immunotherapy, precise roles characteristics subtypes, how induces subtype transformation its impact on progression yet to be understood. In this review, we comprehensively center four major within particularly neutrophils, macrophages, lymphocytes, myeloid-derived suppressor (MDSCs), other significant cells. We discuss (1) markers, (2) glioma-induced transformation, (3) mechanisms each influencing chemotherapy resistance, (4) therapies targeting cells, (5) cell-associated single-cell sequencing. Eventually, identified subtypes in glioma, summarized exact mechanism concluded progress sequencing exploring glioma. conclusion, analyzed resistance detailly, discovered prospective immunotherapy targets, excavating potential novel immunotherapies approach that synergistically combines radiotherapy, chemotherapy, surgery, thereby paving way for improved immunotherapeutic strategies against enhanced patient outcomes.
Language: Английский
Citations
2
Cancer/Radiothérapie, Journal Year: 2024, Volume and Issue: 28(5), P. 424 - 434
Published: Sept. 25, 2024
Language: Английский
Citations
2
Biology, Journal Year: 2023, Volume and Issue: 12(10), P. 1295 - 1295
Published: Sept. 28, 2023
Despite countless papers in the field of radioresistance, researchers are still far from clearly understanding mechanisms triggered glioblastoma. Cancer stem cells (CSC) important to growth and spread cancer, according many studies. In addition, more recently, it has been suggested that CSCs have an impact on glioblastoma patients’ prognosis, tumor aggressiveness, treatment outcomes. reviewing this new area biology, we will provide a summary most recent research their role response radio-chemotherapy GB. review, examine radiosensitivity cells. Moreover, summarize current knowledge biomarkers stemness evaluate potential function study radiosensitivity.
Language: Английский
Citations
4
Carcinogenesis, Journal Year: 2023, Volume and Issue: 45(4), P. 235 - 246
Published: Dec. 23, 2023
Abstract Glioma is the most common malignant brain tumor in adults with a high mortality and recurrence rate. Integrin alpha 2 (ITGA2) involved cell adhesion, stem regulation, angiogenesis immune function. The role of ITGA2 glioma invasion remains unknown. function clinical relevance were analysed by bioinformatics databases. expression parent cells GSCs was detected flow cytometry immunofluorescence double staining. on phenotype epithelial–mesenchymal transition (EMT) identified assays Western blot. effect progression vivo determined intracranial orthotopic xenograft model. Immunohistochemistry, Spearman correlation Kaplan–Meier used to analyse relationship features prognosis. Biological analysis showed that might be related migration. ITGA2, enriched co-expressed SOX2, promoted migration activating STAT3 phosphorylation enhancing EMT. knockout suppressed growth prolonged survival mice. In addition, level significantly correlated grade malignancy, N-cadherin Ki67. High indicated worse prognosis patients. As biomarker for prediction prognosis, promotes EMT, leading poor
Language: Английский
Citations
4
Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 266, P. 108762 - 108762
Published: Nov. 26, 2024
Language: Английский
Citations
1
BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)
Published: April 23, 2024
Glioblastoma is a malignant and aggressive type of central nevous system malignancy characterized by many distinct biological features including extensive hypoxia. Hypoxia in glioblatoma associates with complex signaling patterns activation several pathways such as MAPK, PI3K-AKT/mTOR IL-6/JAK/STAT3 the master regulator HIF-1, which turn drive particular tumor behaviors determining, end, treatment outcomes patients fate. Thus, present study was designed to investigate expression selected hypoxia related factors STAT3 small set long-term surviving glioma patients.
Language: Английский
Citations
1
Advanced Therapeutics, Journal Year: 2023, Volume and Issue: 6(12)
Published: Sept. 9, 2023
Abstract Brain cancers, particularly malignant gliomas such as glioblastoma, are highly invasive and characterized by elevated complexity, heterogeneity, high infiltration ability. Therefore, they pose a significant challenge to conventional treatments due the limited drug permeability of blood–brain barrier (BBB), involvement numerous acquired intrinsic resistance mechanisms in metastatic brain tumors, sensitivity surrounding healthy tissues. Despite recent advances diagnosis treatment, their prognosis remains poor, with median overall survival rarely exceeding 12 months. To overcome these limitations, different nanomedicine‐based therapeutic approaches have recently been proposed, aiming provide more effective safer delivery for targeting cancers. However, most reported nanomedicines date failed meet expectations clinic. This fact can be attributed understanding tumor biology lack knowledge about bio‐nanoparticle interactions, among other factors. review discusses progress cancer nanomedicines, particular focus intracellular sorting mechanisms, perivascular growth, design advanced BBB models. It also highlights how an improved pave way designing treatment.
Language: Английский
Citations
3