Comparative study of ergosterol and 7‐dehydrocholesterol and their endoperoxides: Generation, identification, and impact in phospholipid membranes and melanoma cells DOI Open Access
Megumi Nishitani Yukuyama,

Karen Campos Fabiano,

Alex Inague

et al.

Photochemistry and Photobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Melanoma is an aggressive cancer that has attracted attention in recent years due to its high mortality rate of 80%. Damage caused by oxidative stress generated radical (type I reaction) and singlet oxygen, 1 O 2 II reactions may induce cancer. Thus, studies aim unveil the mechanism drives these damage processes become relevant. Ergosterol, analogue 7‐dehydrocholesterol, important structure cell membranes, widely explored treatment. However, date little known about impact different on sterols melanoma treatment, conflicting results their effectiveness complicates understanding role damage. Our highlight differences among ergosterol, 7‐dehydrocholesterol (7‐DHC), cholesterol membrane properties when subjected distinct reactions. Furthermore, we conducted a comparative study exploring mechanisms photodynamic treatment A375 melanoma. Notably, endoperoxides from ergosterol 7‐DHC showed superior efficacy reducing viability cells compared precursor molecules. We also describe step‐by‐step process produce identify derived 7‐DHC. While further are needed, this work provides new insights for death induced presence biologically relevant sterols.

Language: Английский

The cell biology of ferroptosis DOI
Scott J. Dixon, James A. Olzmann

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(6), P. 424 - 442

Published: Feb. 16, 2024

Language: Английский

Citations

294
Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics DOI Creative Commons
Hao-Ran Jin, Jin Wang, Zijing Wang

et al.

Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)

Published: Sept. 12, 2023

Abstract Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and survive in unfavorable environments that lack oxygen nutrients, tumor cells undergo transformations exploit various ways acquiring lipid increasing oxidation. addition, stromal immune the microenvironment also reprogramming, which further affects functional phenotypes responses. Given metabolism plays a critical role supporting cancer progression remodeling microenvironment, targeting pathway could provide novel approach treatment. This review seeks to: (1) clarify overall landscape mechanisms cancer, (2) summarize landscapes within their roles progression, (3) potential therapeutic targets for metabolism, highlight combining such approaches with other anti-tumor therapies new opportunities patients.

Language: Английский

Citations

135
Lipid droplets and cellular lipid flux DOI

Alyssa J. Mathiowetz,

James A. Olzmann

Nature Cell Biology, Journal Year: 2024, Volume and Issue: 26(3), P. 331 - 345

Published: March 1, 2024

Language: Английский

Citations

80
Ferroptosis in health and disease DOI Creative Commons
Carsten Berndt, Hamed Alborzinia,

Vera Skafar Amen

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103211 - 103211

Published: May 30, 2024

Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark ferroptosis uncontrolled overwhelming peroxidation polyunsaturated fatty acids contained membrane phospholipids, which eventually leads to rupture the plasma membrane. unique that it essentially spontaneous, uncatalyzed chemical process based on perturbed iron redox homeostasis contributing process, but nonetheless modulated by many metabolic nodes impinge cells' susceptibility ferroptosis. Among affecting sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets treatment numerous currently incurable diseases. Herein, current members Germany-wide research consortium focusing research, well key external experts who made seminal contributions this rapidly growing exciting field gathered provide comprehensive, state-of-the-art review Specific topics include: basic mechanisms, vivo relevance, specialized methodologies, tools, potential contribution disease etiopathology progression. We hope article will not only established scientists newcomers with an overview multiple facets ferroptosis, also encourage additional efforts characterize further molecular pathways modulating ultimate goal develop novel pharmacotherapies tackle associated - or caused

Language: Английский

Citations

69
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK DOI
Yajuan Li, Daniel Muñoz-Mayorga,

Yuhang Nie

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(6), P. 1351 - 1370.e8

Published: April 23, 2024

Language: Английский

Citations

36
FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer DOI Creative Commons
Nicla Lorito, Angela Subbiani, Alfredo Smiriglia

et al.

EMBO Molecular Medicine, Journal Year: 2024, Volume and Issue: 16(7), P. 1533 - 1559

Published: June 26, 2024

Language: Английский

Citations

18
Lipid droplets and fatty acid‐induced lipotoxicity: in a nutshell DOI Open Access

Eseiwi Obaseki,

Daniel Adebayo,

Sumit Bandyopadhyay

et al.

FEBS Letters, Journal Year: 2024, Volume and Issue: 598(10), P. 1207 - 1214

Published: Jan. 28, 2024

Lipid droplets (LDs) are fat storage organelles that conserved from bacteria to humans. LDs broken down supply cells with fatty acids (FAs) can be used as an energy source or membrane synthesis. An overload of FAs disrupts cellular functions and causes lipotoxicity. Thus, by acting hubs for storing excess fat, prevent lipotoxicity preserve homeostasis. LD synthesis turnover have precisely regulated maintain a balanced lipid distribution allow adaptation during stress. Here, we discuss how prolonged exposure lipids affects functions, the roles in buffering stress focusing on

Language: Английский

Citations

17
Lipid Droplets and Neurodegeneration DOI
Keya Mallick,

Shuchismita Paul,

Sayani Banerjee

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 549, P. 13 - 23

Published: May 6, 2024

Language: Английский

Citations

17
Protection Strategies Against Palmitic Acid-Induced Lipotoxicity in Metabolic Syndrome and Related Diseases DOI Open Access
Zeltzin Alejandra Ceja-Galicia, Carlos L. Céspedes, Mohammed El‐Hafidi

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 788 - 788

Published: Jan. 18, 2025

Diets rich in carbohydrate and saturated fat contents, when combined with a sedentary lifestyle, contribute to the development of obesity metabolic syndrome (MetS), which subsequently increase palmitic acid (PA) levels. At high concentrations, PA induces lipotoxicity through several mechanisms involving endoplasmic reticulum (ER) stress, mitochondrial dysfunction, inflammation cell death. Nevertheless, there are endogenous strategies mitigate PA-induced its unsaturation elongation channeling storage lipid droplets (LDs), plays crucial role sequestering oxidized lipids, thereby reducing oxidative damage membranes. While extended exposure promotes reactive oxygen species (ROS) generation leading damage, acute ß-cells increases glucose-stimulated insulin secretion (GSIS), activation free fatty receptors (FFARs). Subsequently, FFARs by exogenous agonists has been suggested as potential therapeutic strategy prevent ß cells. Moreover, some acids, including oleic acid, can counteract negative impact on cellular health, suggesting complex interaction between different dietary fats outcomes. Therefore, challenge is peroxidation unsaturated acids utilization natural antioxidants. This complexity indicates necessity for further research into function diverse pathological conditions find main target against lipotoxicity. The aim this review is, therefore, examine recent data regarding mechanism underlying order identify that promote protection lipotoxicity, dysfunction apoptosis MetS obesity.

Language: Английский

Citations

3
Gut microbiota is involved in male reproductive function: a review DOI Creative Commons

Shuya Lv,

Jingrong Huang,

Yadan Luo

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: May 3, 2024

Globally, ~8%−12% of couples confront infertility issues, male-related issues being accountable for 50%. This review focuses on the influence gut microbiota and their metabolites male reproductive system from five perspectives: sperm quality, testicular structure, sex hormones, sexual behavior, probiotic supplementation. To improve can secrete by themselves or regulate host metabolites. Endotoxemia is a key factor in structure damage that causes orchitis disrupts blood-testis barrier (BTB). In addition, hormone levels participating synthesis hormone-related enzymes directly enterohepatic circulation affect hypothalamic-pituitary-testis (HPT) axis. They also activate areas brain control arousal behavior through Probiotic supplementation function. Therefore, may function behavior; however, further research needed to better understand mechanisms underlying microbiota-mediated infertility.

Language: Английский

Citations

10