Contributions of white adipose tissue to energy requirements for female reproduction

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(9), P. 809 - 820

Published: May 14, 2024

Language: Английский

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Going Beyond Childhood and Gender-Based Violence: Epigenetic Modifications and Inheritance

Women s Health Reports, Journal Year: 2024, Volume and Issue: 5(1), P. 473 - 484

Published: April 1, 2024

Being exposed to childhood or gender-based violence is associated with subsequent adverse events in individual lives. Not only can it cause psychological distress but survivors suffer from a range of long-term health outcomes, including higher morbidity, mortality, and risk chronic diseases. Epigenetics may be involved the determinisms these detrimental effects. A large body evidence supports this biological mechanism explain violence-related impairment long term. However, studies specifically focusing on are scant nonunivocal. Epigenetic modifications genes stress response hypothalamus–pituitary–adrenal axis regulation most commonly consistently reported. Promising also emerged for use epigenetic clocks. Finally, although very limited, there supporting notion that transmitted one generation other. Overall, despite promising, available yet incomplete. The overlap pure mechanisms exposes findings confounders hampers strong conclusions. Based literature search PubMed/Embase, our narrative review aims illustrate concerning potential bond between epigenetics violence, possible impacts later generations. goal encourage further research help development more holistic approach such vulnerable often neglected population. Further warranted precisely disentangle role mediating violence. Advances area open new avenues treatment. indeed reversible could an attractive therapeutic target minimize consequences

Language: Английский

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The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures

Clinical Epigenetics, Journal Year: 2023, Volume and Issue: 15(1)

Published: May 4, 2023

Abstract The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates industrialised countries. Epigenetic mechanisms impact on proper embryonic development women undergoing vitro fertilisation (IVF) protocols. Here, we describe main epigenetic modifications that may influence female reproduction could affect IVF success. Graphical

Language: Английский

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Teorías del envejecimiento biológico: una revisión integradora

Revista Española de Geriatría y Gerontología, Journal Year: 2024, Volume and Issue: 59(6), P. 101530 - 101530

Published: July 11, 2024

Language: Английский

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Physical Activity and Epigenetic Aging in Breast Cancer Treatment

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8596 - 8596

Published: Aug. 6, 2024

Biological age, reflecting the cumulative damage in body over a lifespan, is dynamic measure more indicative of individual health than chronological age. Accelerated aging, when biological age surpasses implicated poorer clinical outcomes, especially for breast cancer (BC) survivors undergoing treatments. This preliminary study investigates impact 16-week online supervised physical activity (PA) intervention on post-surgery female BC patients. Telomere length was measured using qPCR, and ELOVL2-based epigenetic clock assessed via DNA methylation pyrosequencing

Language: Английский

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The End of Aging – Hintergründe einer transgressiven Medizin

Die Gynäkologie, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

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Epigenomic Landscape of Human Cumulus Cells in Premature Ovarian Insufficiency Using Single‐Base Resolution Methylome and Hydroxymethylome

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(24)

Published: Dec. 1, 2024

ABSTRACT Premature ovarian insufficiency (POI) has recently been reported to be linked with epigenetic changes. Previous studies have focused on the regulation of individual genes associated function through single‐gene variations; however, there is a deficiency in comprehensive comprehension profile for POI. Therefore, we conducted multi‐omics study integrating methylation, hydroxymethylation and transcriptome sequencing analyses cumulus cells from women POI their matched controls. Our data revealed significant global increases methylation levels patients. We observed predominance hypermethylated hyperhydroxymethylated regions across genome, gene bodies negatively correlating expression, especially promoter regions. Subsequent experimental validation was performed confirm involvement candidate (EGR1, EGR2 DLX5) steroid hormone synthesis. Interestingly, our findings indicate that these modifications are implicated POI, age clock. This underscores potential identifying novel biomarkers therapeutic targets by unravelling complex interplay between DNA epigenetics function.

Language: Английский

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Quantifying Tissue Response after Intraovarian Platelet-Rich Plasma: Experimental Approach to Assess NF-κB and TNF-α as Mediators to Reduce Local Entropy

Published: Aug. 14, 2023

Diminished ovarian reserve can be regarded as a sentinel indicator to foreshadow severe follicular loss and, ultimately, systemic aging. The negative slope of human ovulatory fidelity begins with robust endowment which gradually declines over time. In contrast, the youthful phenotype requires coordinated work endothelial, granulosa, immune, perivascular, stromal and possibly germline stem cells. Such diverse tissue matrix can, in general, influenced by platelet (PLT)-derived factors but this has not yet been specifically confirmed ovary after platelet-rich plasma (PRP). How could comparable response validated? Here prospective, experimental study is proposed whereby eligible patients already undergoing scheduled laparoscopy provide via biopsy submitted for co-culture autologous Ca+2 activated PRP. Recognizing interlocking, central roles nuclear factor κB (NF-κB) tumor necrosis factor-α (TNF-α), incubated samples would assessed these vitro before vs. PRP exposure, addition stereomicroscopy. A mathematical model available track NF-κB oscillations estimate gene expression, cell development, growth, apoptosis, key immune inflammatory actions. Since TNF-α are discharged PLT releasate (or react its cargo proteins) audit permits extraction markers observed post-stimulus, thus linking discrete signals transcriptional output, cellular fitness, cytoarchitecture. From this, hypothesis emerge where intraovarian found make no direct impact on follicles, although modified field function curtailed local entropy incidentally favor optimized oocyte competence secondary effect.

Language: Английский

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Subfertility as Overlapping of Nutritional, Endocrine, Immune, and Cardiometabolic Dysregulations—A Study Focused on Biochemical Endophenotypes of Subfertile Couples

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(18), P. 6094 - 6094

Published: Sept. 21, 2023

Subfertility is a global health issue, and as many 30% of cases are attributed to unexplained reasons. A hypercaloric, high-fat diet stimulates the expansion pro-inflammatory gut microbiota with consequent rise in circulating lipopolysaccharides. Adverse remodeling can exacerbate insulin resistance, while sex thyroid hormones may influence variability microbiota. This cross-sectional study included 150 participants was designed determine biochemical, nutritional-related pattern that distinguish subfertile from fertile individuals couples. panel 28 biomarkers assessed. Four biochemical phenotypes subfertility were found, including two metabolic immune, when assessed using binary logistic regression models. Two distinguished women: cardio-metabolic atherogenic dyslipidemia (LowHDL-cholesterol: OR = 10.9; p < 0.05) autoimmune disorder (Highanti-thyroid-peroxidase: 5.5; men: hepato-metabolic elevated liver injury enzymes (HighHOMA-IR: 6.1; immune type-2 response (HighIgE: 6.4; 0.05). The chances couple’s rose number laboratory components syndrome couple (OR 1.7; if at least one partner had an total IgE level (>100 kU/L) 6.5; found be accompanied by mutually overlapping dysregulations We propose one-time diagnostics taking into account lipid profile, anti-thyroid-peroxidase, both males females subfertility. allow for assessment targeted medical nutritional interventions help optimize patients’ health. gut–organ axes related discussed context obtained results.

Language: Английский

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Epigenetic age acceleration in follicular fluid and markers of ovarian response among women undergoing IVF

Human Reproduction, Journal Year: 2024, Volume and Issue: 39(9), P. 2003 - 2009

Published: June 18, 2024

Are markers of epigenetic age acceleration in follicular fluid associated with outcomes ovarian stimulation?

Language: Английский

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