Uncovering a causal connection between the Lachnoclostridium genus in fecal microbiota and non-alcoholic fatty liver disease: a two-sample Mendelian randomization analysis DOI Creative Commons

Wanhui Dai,

Dandong Cai,

Shuai Zhou

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 12, 2023

Background Previous observational studies have indicated that an imbalance in gut microbiota may contribute to non-alcoholic fatty liver disease (NAFLD). However, given the inevitable bias and unmeasured confounders studies, causal relationship between NAFLD cannot be deduced. Therefore, we employed a two-sample Mendelian randomization (TSMR) study assess causality NAFLD. Methods The microbiota-related genome-wide association (GWAS) data of 18,340 individuals were collected from International MiBioGen consortium. GWAS summary for Anstee cohort (1,483 cases 17,781 controls) FinnGen consortium (894 217,898 utilized discovery verification phases, respectively. inverse variance weighted (IVW) method was used as principal our (MR) study, with sensitivity analyses using MR-Egger, median, simple mode, mode methods. MR-Egger intercept test, Cochran’s Q leave-one-out analysis conducted identify heterogeneity pleiotropy. Moreover, fixed-effect meta-analysis verify robustness results. Results gene prediction results showed at genus level, four causally associated by et al. relative abundance Intestinimonas (OR: 0.694, 95%CI: 0.533–0.903, p = 0.006, IVW), Lachnoclostridium 0.420, 0.245–0.719, 0.002, Senegalimassilia 0.596, 0.363–0.978, 0.041, IVW) negatively Ruminococcus1 1.852, 1.179–2.908, 0.007, positively correlated Among them, validated 0.53, 0.304–0.928, 0.026, IVW). also significantly risk meta-analyses 0.470, 0.319–0.692, 0.0001, No or pleiotropy observed. Conclusion This provided new evidence NAFLD, suggesting augmentation through oral administration probiotics fecal transplantation could effective way reduce

Language: Английский

The causality between gut microbiome and anorexia nervosa: a Mendelian randomization analysis DOI Creative Commons
Xuan Xia, Shuyang He, Xiaolin Zhang

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 19, 2023

Nutrient production by intestinal microbiota corresponds to regulate appetite while gut microbial composition was influenced diet ingestion. However, the causal relationship between taxa and anorexia nervosa (AN) remains unclear. Mendelian Randomization (MR) is a novel research method that effectively eliminates interference of confounding factors allows for exploration direct effects exposure outcome. This study employs MR explore effect AN specific microbiome. Large-scale Genome Wide Association Study (GWAS) data 211 microbes were obtained from IEU open GWAS project Mibiogen Consortium. Two-sample performed determine AN. Furthermore, bi-directional analysis examine direction relations. The Bonferroni correction test used adjust potential correlations among taxa. In forward analysis, 10specific have an impact on occurrence (the p value IVW <0.05). high abundance Genus Eubacteriumnodatumgroup ID: 11297 (OR:0.78, 95% CI:0.62-0.98, = 0.035) Class Melainabacteria 1589 (OR:0.72, CI:0.51-0.99, 0.045) may be considered protective But after correction, only Actinobacteria ID:419 (OR:1.53, CI:1.19-1.96, 0.00089) remained significantly associated as risk factor reverse influences 8 with none-statistically significant associations adjustment. We identified correlation 18 which not been previously reported. Among them, 10 kinds bacteria affect AN, status would bacteria. After continued exert influence

Language: Английский

Citations

12
The causality between gut microbiome and liver cirrhosis: a bi-directional two-sample Mendelian randomization analysis DOI Creative Commons
Qing-Ao Xiao, Yunfei Yang, Lin Chen

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 18, 2023

Previous studies have reported an association between gut microbiota and cirrhosis. However, the causality intestinal flora liver cirrhosis still remains unclear. In this study, bi-directional Mendelian randomization (MR) analysis was used to ascertain potential causal effect microbes cirrhosis.Large-scale Genome Wide Association Study (GWAS) data of were obtained from FinnGen, Mibiogen consortium, a GWAS meta-analysis Alcoholic (ALC). Two-sample MR performed determine relationship Furthermore, employed examine direction relations.In analysis, we found that 21 microbiotas potentially associated with reverse 11 displayed associations genetic liability in microbiome We family Lachnospiraceae (OR: 1.59, 95% CI:1.10-2.29) might be harmful cirrhotic conditions (ICD-10: K74). genus Erysipelatoclostridium protective factor for (OR:0.55, CI:0.34-0.88) PBC (OR:0.68, CI:0.52-0.89). Combining results firstly identified Genus Butyricicoccus had on (Forward: OR: 0.37, CI:0.15-0.93; Reverse: 1.03, CI:1.00-1.05).We new provided insights into role pathological progression

Language: Английский

Citations

10
Beyond pain: The surprising connection between tramadol and depression DOI Creative Commons
Kaiqin Chen, Hong Wu,

Yingbing Fang

et al.

Psycho-Oncologie, Journal Year: 2025, Volume and Issue: 19(1), P. 3628 - 3628

Published: Jan. 10, 2025

Language: Английский

Citations

0
The protective effects of cheese intake on joint pain and underlying biomarkers: Insights from the Mendelian randomization DOI Creative Commons
Kaiqin Chen, Jianwu Wu, Yaolin Xu

et al.

Journal of Dairy Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

This study aimed to investigate the relationship between cheese consumption and risk of joint pain, as well assess mediating role biomarkers. Utilizing Mendelian randomization methods, we analyzed data from UK Biobank FinnGen evaluate link intake examining 44 biomarkers potential mediators. The findings revealed a significant inverse association mediated by various biomarkers, including neutrophil count, apolipoprotein A, peak expiratory flow, cystatin C, IGF-1, sex hormone–binding globulin, urate, automated diastolic blood pressure. These results suggest that may reduce pain affecting specific providing scientific basis for dietary interventions decrease incidence pain. However, study's limitations include ethnic homogeneity sample population incomplete analysis indicating need further research confirm expand upon these initial findings.

Language: Английский

Citations

0
Effect of erythropoiesis-stimulating agents on malignant neoplasms: FAERS database and mendelian randomization DOI
Cuilv Liang, Qiaohong Wang, Peihong Wang

et al.

Expert Review of Hematology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

The relationship between erythropoiesis-stimulating agents (ESAs) and malignant neoplasms (MNs) has been controversial in previous studies. Our study aimed to explore the correlation ESAs MNs. Drug-target Mendelian randomization (MR) analyses were conducted evaluate causal associations of for 12 classifications Meanwhile, a pharmacovigilance was performed by extracting adverse events (AEs) FDA Adverse Event Reporting System (FAERS) database validate complement our findings. MR analysis revealed negative association with MN ovary (p = 0.047), liposarcoma(p 0.001), small cell lung cancer(p 0.017), colorectal 0.004), brain meningioma(p positive bladder eye adnexa 0.012), heart, mediastinum pleura 0.032), lip 0.041), larynx 0.015)，non cancer 0.009), melanoma 0.001). Positive signals found hematological system, digestive organs, central nervous adnexa, head neck cancer, mucinous cystic tumor FAERS (all reporting odds ratio (ROR) proportional (PRR) >1). causally correlated many types More attention needs be paid use these tumors.

Language: Английский

Citations

0
Associations Between Gut Microbiota and Diabetic Nephropathy: A Mendelian Randomization Study DOI Creative Commons
Yujun Xiong, Xingyun Zhu,

Hua-Zhao Xu

et al.

Aging Medicine, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 1, 2025

ABSTRACT Objectives Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, and its pathogenesis remains incompletely understood. Emerging evidence suggests potential link between gut microbiota DN. This study aimed to explore the causal relationship DN using two‐sample Mendelian randomization (MR) approach. Methods Gut data were obtained from MiBioGen consortium, which provides most comprehensive genome‐wide association studies (GWAS) on microbiota. Summary‐level genetic for sourced publicly available GWAS provided by FinnGen consortium. The primary analysis was conducted inverse variance–weighted (IVW) method, complemented sensitivity analyses evaluate pleiotropy heterogeneity. Results Fourteen species demonstrated significant associations with in MR analysis, including five negatively nine positively associated species, as determined IVW method. No or heterogeneity observed, ensuring robustness findings. Conclusions novel insight into role pathogenesis, uncovering specific microbial that may contribute disease progression. These findings offer promising avenue future research therapeutic development targeting

Language: Английский

Citations

0
Moderate and severe depression increase the incidence of cholelithiasis: Results from Mendelian randomization study and the NHANES 2017-March 2020 DOI

Mingxiu Ma,

Kailing Xie, Tianqiang Jin

et al.

Social Psychiatry and Psychiatric Epidemiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Language: Английский

Citations

0
Genetic evidence of increased schizophrenia risk due to antidepressant use in European and East Asian populations DOI
Zhiqiang Du, Xiangjun Zhou, Qin Zhou

et al.

The European Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 39(2), P. 100302 - 100302

Published: March 1, 2025

Language: Английский

Citations

0
Gut microbiota, blood metabolites, & pan-cancer: a bidirectional Mendelian randomization & mediation analysis DOI Creative Commons

Biqing Luan,

Yang Yang, Qizhi Yang

et al.

AMB Express, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 2, 2025

We propose using Mendelian randomization analysis on GWAS data and MetaboAnalyst to model gut microbiota, metabolic pathways, blood metabolites, cancer risk. examined 473 205 1400 8 cancers. Results were validated through bidirectional two-sample Randomization (MR), heterogeneity tests, pathway enrichment, leading a mediation model. identified 129 57 463 metabolites linked cancer, 34 significant plasma pathways. 15 58 implicated in multiple Eight pathways are involved the development of types cancer. Through Multivariate (MVMR) analysis, we found 9 offering novel targets research directions for pathogenesis treatment.

Language: Английский

Citations

0
Causal Effects of Circulating Micronutrients on Cognitive Function: Evidence From a Mendelian Randomization Study DOI Creative Commons
S. J. Yuan,

Chang‐hai Long,

Xu Zhang

et al.

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(4)

Published: April 1, 2025

ABSTRACT Background Cognitive impairment is a growing concern worldwide, driven by an aging population. Emerging evidence suggests that micronutrients may play critical roles in maintaining cognitive health and preventing neurodegeneration. However, the causal relationships between specific function remain unclear. Methods This study employed two‐sample Mendelian randomization (MR) approach to investigate effects of 16 circulating on function. Genetic variants associated with micronutrient levels were used as instrumental variables (IVs), outcomes, including reaction time, performance, prospective memory, fluid intelligence, assessed using publicly available genome‐wide association (GWAS) datasets. Sensitivity analyses conducted evaluate heterogeneity, pleiotropy, robustness findings. Results MR analysis revealed potential positive β‐carotene phosphorus reflecting faster responses. Vitamin E was positively while vitamin B6 had negative effect. Selenium correlated whereas elevated A1 reduced intelligence. No significant associations observed for other across domains assessed. Conclusion highlights micronutrients, like β‐carotene, phosphorus, selenium, E, health, excessive be harmful, warranting further investigation.

Language: Английский

Citations

0