Febrile seizures in pediatric practice: Risk factors, clinical manifestations, and intensive therapy DOI Creative Commons

Yu. V. Bykov,

А. Н. Обедин,

V. V. Fischer

et al.

Ural Medical Journal, Journal Year: 2023, Volume and Issue: 22(6), P. 113 - 123

Published: Dec. 24, 2023

Introduction. Febrile seizures (FS) is the most common type of epileptic seizure experienced by young children. Study methods intensive treatment (IT) FS represents a vital area research in today’s pediatric science. The aim this work: to assess current approaches risk factors, clinical manifestations and emergency care for patients with practice. Materials methods. authors performed an analysis publications that were found Cochrane Library, PubMed, eLibrary.ru, Medscape databases using following search terms: febrile seizures, children adolescents, treatment, anticonvulsants. A total 64 published sources chosen review. Results Discussion. factors may be numerous, main etiological causes being genetic susceptibility, viral infections vaccination. presentation characterized development generalized tonic-clonic setting high body temperature (≥39°C). are subdivided into three types: simple, complex status epilepticus (FSE). History taking physical examination represent diagnostic means determining discovering cause infection. Laboratory tests, electroencephalography, neuroimaging studies lumbar puncture used on limited basis, mainly complicated accompanied brain Hospitalization IT necessary if child has prolonged or FSE. drugs choice relieving benzodiazepines. Barbituric acid derivatives valproic also possess therapeutic efficacy against FS. Antipyretic agents effective only toxic syndrome, but have no effect severity do not prevent relapses. antipyretic medications practice paracetamol, ibuprofen nimesulide. Besides benzodiazepines, FSE involves use intravenous fosphenytoin, phenobarbital levetiracetam. Conclusion. Improvement quality improve prognosis bring down complication mortality rates.

Language: Английский

A Decade of Dedication: Pioneering Perspectives on Neurological Diseases and Mental Illnesses DOI Creative Commons
Masaru Tanaka, László Vécsei

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1083 - 1083

Published: May 13, 2024

Welcome to

Language: Английский

Citations

18
Long-Term Fish Oil Supplementation Attenuates Spike Wave Discharges in the Amygdala of Adult Rats with Early-Life Febrile Seizures DOI Creative Commons

Leopoldo Eduardo Flores-Mancilla,

Marisela Hernández‐González,

Miguel Ángel Guevara-Pérez

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(4), P. 395 - 395

Published: April 14, 2025

Background and Objectives: Febrile seizures (FS) are neuronal disturbances frequently associated with abnormal electroencephalographic activity (EEG) as spike-wave discharges (SWDs). Fish oil (FO) has high amounts of omega-3 fatty acids (θ-3), its effects on FS alterations poorly understood. The aim this work was to evaluate the effect long-term FO supplementation EEG amygdala adult male rats early-life FS. Materials Methods: Progenitor female Wistar rats, from puberty gestation delivery, were fed daily a commercial diet supplemented either fish (FO), palm (PO), or deionized water (CTRL). After parturition, pups exposed for 30 min hyperthermia (HP) then returned their dams. weaning, respective treatments up 155 days age when electrodes implanted in amygdala. Results: During early life HP, PO CTRL groups reached maximal core temperature (CT) comparison group. Furthermore, group only fewer myoclonus long latency adopt an uncontrolled posture. At age, scored shorter periods SWDs but without presented minor values absolute power than groups. Conclusions: In minimizes deleterious behavioral caused by decreases occurrence amplitude

Language: Английский

Citations

0
Curcumin attenuates neuroinflammation and improves cognitive function in a rat model of febrile convulsions DOI Creative Commons

Hamdiye Celikaslan,

Davut Sinan Kaplan, Mustafa Örkmez

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 28, 2025

This study aimed to investigate the effects of curcumin on neuroinflammation and cognitive function in a rat model febrile convulsions (FC). was conducted 10-day-old male Wistar pups, randomly assigned four groups: Control, Curcumin, FC, FC + Curcumin. were induced by placing rats 44 °C water bath until occurred or for maximum 4 min. Curcumin (200 mg/kg/day) administered intraperitoneally seven consecutive days before induction. Neuroinflammation assessed measuring hippocampal serum TNF-α IL-1β levels using ELISA. Cognitive evaluated Morris Water Maze (MWM) test, where escape latency, swimming speed, distance traveled recorded, followed probe test Day 5 assess memory retention. Motor coordination Rotarod latency fall. treatment significantly reduced (FC group: 145.3 ± 12.1 pg/mL vs. 98.6 9.4 pg/mL, p = 0.001). In MWM curcumin-treated exhibited shorter latencies improved spatial performance compared group (p < 0.05). By 4, had 42.8 5.9 s 25.3 4.1 s, 0.002) reach platform 335.4 22.8 cm 192.6 18.3 cm, administration termination time 96.7 7.4 62.5 exerts neuroprotective reducing improving function. These findings suggest that could be promising therapeutic agent managing seizure-related dysfunction. Further studies are warranted explore its long-term efficacy clinical applicability.

Language: Английский

Citations

0
Neonatal febrile seizures: Dimethyl itaconate’s role in behavioral recovery and glutathione enzyme modulation in adult rats DOI Creative Commons
Zohreh Ghotbeddin, Mohammad Ali Farboodniay Jahromi, Ali Shahriari

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0318430 - e0318430

Published: March 25, 2025

Febrile seizures are common in children and can lead to neurological deficits like motor impairments, memory problems, cognitive decline. Research on dimethyl itaconate aims mitigate these effects improve the quality of life for affected people. By exploring its potential as a protective agent against oxidative stress during seizures, this study adult male rats measures activity key enzymes related behavioral performance. Pregnant were divided into control, sham, DMI, febrile seizure, DMI + seizure groups. Seizure severity was evaluated through threshold frequency measurements, while memory, function, balance assessed using shuttle box, rotarod, open field, wire hanging tests. After that, hippocampus tissue removed from brain levels MDA, SOD, GSH, TAC, GR, GPx, catalase measured biochemical methods. Results show that raised reduced tonic-clonic seizures. The group also showed improved movement, compared (p < 0.05 all cases). Overall, decreased outcomes fever-affected rats.

Language: Английский

Citations

0
Febrile temperature-regulated TRPV1 in CD4+ T cells mediates neuroinflammation in complex febrile seizures DOI Creative Commons

Shuo Kong,

Xianglei Jia,

Liang Xin

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: April 7, 2025

Language: Английский

Citations

0
Febrile seizures in an app-based children’s fever registry: (Preprint) DOI
David Martín,

Ricarda Möhler,

Christopher B. Germann

et al.

Published: April 2, 2025

BACKGROUND Febrile seizures, although typically benign, can cause significant emotional distress for parents. Their diverse etiological risk factors underscore the need further research. Ecological Momentary Assessment (EMA) offers a cost-effective and timely method real-time data collection. The FeverApp, an EMA-based registry fever management, enables parents to document febrile seizures as they occur. OBJECTIVE This study systematically evaluates seizure records from FeverApp assess their characteristics explore clinical implications of findings. By providing real-world on this research demonstrates potential app-based EMA in pediatric care. Additionally, it insights targeted interventions improved management. METHODS Parents descriptions 226 belonging 161 children were qualitatively analysed. Group differences quantitative assessed through matched-pair sampling, comparing 114 children. Statistical methods tailored nature respective variables, which included prevalence, age, gender, health history, temperature, well-being, parental confidence. RESULTS Qualitative analyses provided detailed symptoms, duration, management practices. revealed high rate emergency consultations related seizures. However, there was underreporting within with reported incidence only 0.4% among In matched sample controlled gender observed between without several parameters, including maximum recorded temperature (P < .001), prevalence chronic diseases = 0.004), confidence 0.014), frequency .001). CONCLUSIONS valuable into characteristics, temporal dynamics, strategies, responses Despite limitation registry, findings highlight critical importance education support managing Enhancing these areas has reduce unnecessary medical improve overall care affected Furthermore, integrating improvements FeverApp's documentation system regarding could facilitate better future efforts. CLINICALTRIAL DRKS00016591

Language: Английский

Citations

0
Additive interaction between birth asphyxia and febrile seizures on autism spectrum disorder: a population-based study DOI Creative Commons
Yi Mao, Xindi Lin, Yuhan Wu

et al.

Molecular Autism, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 10, 2024

Abstract Background Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder that can significantly impact an individual’s ability to socially integrate and adapt. It’s crucial identify key factors associated with ASD. Recent studies link both birth asphyxia (BA) febrile seizures (FS) separately higher ASD prevalence. However, investigations into the interplay of BA FS its relationship are yet be conducted. The present study mainly focuses on exploring interactive effect between in context Methods Utilizing multi-stage stratified cluster sampling, we initially recruited 84,934 Shanghai children aged 3–12 years old from June 2014 2015, ultimately including 74,251 post-exclusion criteria. A logistic regression model was conducted estimate interaction after controlling for pertinent covariates. attributable proportion (AP), relative excess risk due (RERI), synergy index (SI), multiplicative-scale were computed determine effect. Results Among total children, 192 (0.26%) diagnosed adjusted odds ratio alone 3.82 (95% confidence interval [CI] 2.42–6.02), 3.06 (95%CI 1.48–6.31), comorbid 21.18 9.10–49.30), versus without or FS. additive showed statistical significance ( P < 0.001), whereas multiplicative statistically insignificant > 0.05). Limitations This only demonstrate but cannot prove causation. Animal brain experimentation necessary unravel neural mechanisms. larger sample size, ongoing monitoring, detailed classification needed confirming BA-FS Conclusion In this extensive cross-sectional study, linked coexistence these increase prevalence, surpassing cumulative each individual factor.

Language: Английский

Citations

1
Performance, impact and experiences of using wearable devices for seizure detection in community-based settings: a mixed methods systematic review DOI Open Access
Maxime Sasseville, Eugène Attisso, Marie‐Pierre Gagnon

et al.

mHealth, Journal Year: 2023, Volume and Issue: 0, P. 0 - 0

Published: Jan. 1, 2023

There is growing scientific evidence that wearable devices for seizure detection (WDD) perform well in controlled environments. However, their impact on the health and experience of patients with epilepsy (PWE) community-based settings less documented. We aimed to synthesize about performance used by PWE settings, outcomes patient experience.

Language: Английский

Citations

1
Evaluation of Neutrophil Gelatinase-Associated Lipocalin Levels in Children With Febrile Seizures: A Case-Control Study DOI
Mohamed Kassem, Amany Abbass, Heba A. Ahmed

et al.

Clinical Pediatrics, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Febrile seizure (FS) is a common pediatric neurological disorder, which may be associated with hypoxia and kidney injury. We aimed to investigate serum levels of neutrophil gelatinase-associated lipocalin (NGAL) in children FS. This case-control study included 50 FS, febrile controls (FCs), healthy (HCs). measured NGAL using human enzyme-linked immunosorbent assay. Serum NGAL/creatinine values showed significant differences within between groups the highest for FS group (1382 ± 215), middle FCs (1133 129), lowest HCs (857 97). None participants had abnormal creatinine levels, their were comparable among 3 groups. In conclusion, have increased despite normal creatinine, indicating that could contribute subclinical renal injury without loss excretory function.

Language: Английский

Citations

0
Research progress on pathogenesis and treatment of febrile seizures DOI
Chang L. Wu, Qingmei Wang, Wei Li

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123360 - 123360

Published: Dec. 1, 2024

Language: Английский

Citations

0