GeroScience,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 12, 2024
Abstract
Early
nutrition
has
significant
effects
on
physiological
outcomes
during
adult
life.
We
have
analysed
the
effect
of
maternal
α-casein
(CSN1S1)
deficiency
fate
dams
and
their
offspring.
reduces
milk
protein
concentration
by
more
than
50%
attenuates
growth
pups
to
27%
(
p
<
0.001)
controls
at
point
weaning.
This
is
associated
with
a
permanent
reduction
in
body
weight
(−
31%
25
weeks).
Offspring
nursed
deficient
showed
significantly
increased
lifespan
(+
20%,
χ
2
:
10.6;
=
0.001).
Liver
transcriptome
analysis
offspring
weaning
revealed
gene
expression
patterns
similar
those
found
dwarf
mice
(reduced
somatotropic
axis
signalling
genes,
xenobiotic
metabolism
genes).
In
mice,
genes
returned
control
levels.
demonstrates
that,
contrast
attenuation
GH-IGF
transient,
while
changes
size
are
permanent.
composition.
Absolute
relative
adipose
tissue
weights
0.05),
percentage
fat
as
well
adipocyte
epididymal
white
all
reduced.
Serum
leptin
levels
were
25%
lipid
content
composition
altered
response
postnatal
nutrition.
early
life
programmes
metabolism,
lifespan.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(26), P. 11320 - 11330
Published: June 20, 2024
Placental
DNA
methylation
(DNAm)
may
be
a
potential
mechanism
underlying
the
effects
of
prenatal
bisphenol
analogues
(BPs)
exposure
on
reproductive
health.
Based
Shanghai-Minhang
Birth
Cohort
Study
(S-MBCS),
this
study
investigated
associations
placental
DNAm
at
reproduction-related
genes
with
BPs
and
children's
digit
ratios
age
4
using
multiple
linear
regression
models,
mediation
analysis
was
further
used
to
examine
mediating
role
in
between
among
345
mother-child
pairs.
Prenatal
A
(BPA)
associated
hypermethylation
Protocadherin
8
(
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 22, 2024
Abstract
In
the
era
of
renewed
space
exploration,
comprehending
effects
environment
on
human
health,
particularly
for
deep
missions,
is
crucial.
While
extensive
research
exists
impacts
spaceflight,
there
a
gap
regarding
female
reproductive
risks.
We
hypothesize
that
stressors
could
have
enduring
potentially
increasing
risks
future
pregnancies
upon
return
to
Earth,
related
small-for-gestational-age
(SGA)
fetuses.
To
address
this,
we
identify
shared
microRNA
(miRNA)
signature
between
SGA
and
environment,
conserved
across
humans
mice.
These
miRNAs
target
genes
pathways
relevant
diseases
development.
Employing
machine
learning
approach,
potential
FDA-approved
drugs
mitigate
these
risks,
including
estrogen
progesterone
receptor
antagonists,
vitamin
D
DNA
polymerase
inhibitors.
This
study
underscores
pregnancy-related
health
astronauts
proposes
pharmaceutical
interventions
counteract
impact
travel
health.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 7287 - 7287
Published: July 2, 2024
Preeclampsia
(PE)
is
a
pregnancy-specific
disorder
associated
with
shallow
invasion
of
the
trophoblast
cells
and
insufficient
remodeling
uterine
spiral
artery.
Protein
glycosylation
plays
an
important
role
in
cell
invasion.
However,
glycobiological
mechanism
PE
has
not
been
fully
elucidated.
In
current
study,
employing
Lectin
array,
we
found
that
soybean
agglutinin
(SBA),
which
recognizes
terminal
N-acetylgalactosamine
α1,3-galactose
(GalNAc
α1,3
Gal)
glycotype,
was
significantly
increased
placental
from
patients
compared
third-trimester
pregnant
controls.
Upregulating
expression
key
enzyme
N-acetylgalactosaminyl
transferase
(GTA)
promoted
biosynthesis
GalNAc
Gal
inhibited
migration/invasion
HTR8/SVneo
cells.
Moreover,
methylation
status
GTA
promoter
tissues
lower
than
third
trimester
by
methylation-specific
PCR
(MSP)
bisulfite
sequencing
(BSP)
analysis.
Elevated
combination
DNA
inhibitor
5-azacytidine
(5-AzaC)
treatment
glycotype
impaired
potential
cells,
leading
to
preeclampsia.
This
study
suggests
elevated
may
be
applied
as
new
markers
for
evaluating
function
auxiliary
diagnosis
