JOR Spine,
Journal Year:
2024,
Volume and Issue:
7(4)
Published: Dec. 1, 2024
Abstract
Background
Intervertebral
disc
degeneration
(IDD)
is
a
progressive
age‐related
disorder
characterized
by
the
reduction
in
number
of
nucleus
pulposus
cells
(NPCs)
and
degradation
extracellular
matrix
(ECM),
thereby
leading
to
chronic
pain
disability.
The
pathogenesis
IDD
multifaceted,
current
therapeutic
strategies
remain
limited.
(NP),
primarily
composed
NPCs,
proteoglycans,
type
II
collagen,
constitutes
essential
components
for
maintaining
intervertebral
(IVD)
function
spinal
motion.
disturbed
homeostasis
NPCs
closely
associated
with
IDD.
Accumulating
evidence
increasingly
suggests
crucial
role
programmed
cell
death
(PCD)
regulating
NPCs.
Aims
This
review
aimed
elucidate
various
forms
PCD
their
respective
roles
IDD,
investigate
diverse
targeting
treatment.
Materials
&
Methods
We
collected
relevant
literature
regarding
development
Subsequently,
we
comprehensively
summarized
intricate
association
between
also
explored
potential
application
therapy
traditional
Chinese
medicine
(TCM)
prevention
treatment
Results
Current
indicated
that
was
Additionally,
targeted
pharmaceuticals
based
on
mechanisms
could
effectively
impede
loss
Conclusion
demonstrated
may
be
promising
strategy
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 29, 2024
Intervertebral
disk
degeneration
(IDD)
is
a
common
clinical
spinal
disease
and
one
of
the
main
causes
low
back
pain
(LBP).
Generally
speaking,
IDD
considered
natural
degenerative
process
with
age.
However,
deepening
research,
people
have
discovered
that
not
only
related
to
age,
but
also
has
many
factors
can
induce
accelerate
its
progression.
In
addition,
pathogenesis
remains
unclear,
resulting
in
limited
traditional
treatment
methods
cannot
effectively
prevent
treat
IDD.
Conservative
may
lead
patients’
dependence
on
drugs,
relief
effect
obvious.
Similarly,
surgical
highly
invasive,
longer
recovery
time
higher
recurrence
rate.
With
exploration,
intestinal
microorganisms
are
an
important
symbiotic
microbial
community
human
body
closely
occurrence
development
various
diseases.
Changes
their
metabolites
affect
body’s
inflammatory
response,
immune
regulation,
metabolic
processes,
thereby
affecting
health
intervertebral
disk.
this
context,
gut
microbiota
received
considerable
attention
as
potential
target
for
delaying
or
treating
This
article
first
introduces
impact
microbes
distal
organs,
then
focuses
three
mechanisms
by
which
influence
Finally,
we
summarized
interfering
metabolites.
Further
understanding
between
will
help
formulate
reasonable
strategies
achieve
ideal
therapeutic
effects.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Dec. 3, 2024
Intervertebral
disc
degeneration
(IDD)
is
a
prevalent
spinal
disorder
and
the
principal
cause
of
lower
back
pain
(LBP).
Diverse
forms
programmed
cell
death
(PCD)
have
been
identified
as
key
phenotypes
disease
potential
to
serve
new
indicators
for
diagnosis
prognosis
IDD.
However,
mechanism
underlying
necroptosis
in
IDD
remains
unclear.
This
study
aimed
identify
novel
biomarkers
that
promote
nucleus
pulposus
using
bioinformatic
analysis
experimental
validation.
We
analyzed
multiple
datasets
from
Gene
Expression
Omnibus
(GEO)
database
necroptosis-related
differential
genes
(NRDEGs).
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
analyses
were
performed,
followed
by
logistic
least
absolute
shrinkage
selection
operator
(LASSO)
support
vector
machine-recursive
(SVM)
algorithms
genes.
set
enrichment
(GSEA)
regression
used
ascertain
functions
these
genes,
respectively.
then
constructed
mRNA-miRNA,
mRNA-TF,
mRNA-drug,
functional
similarity
gene
interaction
networks
seven
identified.
clinical
samples
necroptotic
model
validate
our
findings.
Immunohistochemical
staining,
RT-qPCR,
western
blotting
results
indicated
IRF1
may
be
hub
gene.
To
further
elucidate
function
IRF1,
we
knockdown
overexpression
models,
which
revealed
promotes
rat
cells,
increases
mitochondrial
ROS
levels,
decreases
ATP
levels.
These
findings
provide
insights
into
development
and,
first
time,
role
biomarker
treatment
Turkish Journal of Biochemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 4, 2024
Abstract
Introduction
Bone-degenerative
conditions,
including
osteoporosis,
rheumatoid
arthritis,
and
osteoarthritis,
are
major
public
health
concerns
worldwide,
associated
with
oxidative
stress
iron
overload
that
disrupts
bone
homeostasis.
Ferroptosis,
an
iron-mediated
form
of
cell
death,
has
emerged
as
a
critical
factor
in
degeneration,
necessitating
comprehensive
review
its
role
these
conditions.
Content
This
comprehensively
examined
the
latest
research
on
stress,
metabolism,
ferroptosis
related
to
biology
focusing
their
interconnections
potential
therapeutic
implications.
The
revealed
affects
various
types,
osteoclasts,
osteoblasts,
chondrocytes,
contributing
loss
cartilage
degradation.
Iron
homeostasis
was
found
be
crucial
for
function,
both
deficiency
potentially
leading
pathological
Ferroptosis
regulation
involves
complex
interplay
between
lipid
peroxidation,
antioxidant
systems,
SLC7A11-GSH-GPX4
network
FSP1-CoQ10H2
pathway.
Different
lineages,
mesenchymal
stem
cells,
exhibit
varied
responses
induction
regulation.
Summary
Understanding
molecular
mechanisms
underlying
cells
offers
promising
avenues
developing
targeted
therapies
bone-degenerative
Outlook
Future
should
focus
elucidating
specific
roles
different
disorders
exploring
interventions
targeting
overload,
pathways
improve
management
debilitating
JOR Spine,
Journal Year:
2024,
Volume and Issue:
7(4)
Published: Dec. 1, 2024
Abstract
Background
Intervertebral
disc
degeneration
(IDD)
is
a
progressive
age‐related
disorder
characterized
by
the
reduction
in
number
of
nucleus
pulposus
cells
(NPCs)
and
degradation
extracellular
matrix
(ECM),
thereby
leading
to
chronic
pain
disability.
The
pathogenesis
IDD
multifaceted,
current
therapeutic
strategies
remain
limited.
(NP),
primarily
composed
NPCs,
proteoglycans,
type
II
collagen,
constitutes
essential
components
for
maintaining
intervertebral
(IVD)
function
spinal
motion.
disturbed
homeostasis
NPCs
closely
associated
with
IDD.
Accumulating
evidence
increasingly
suggests
crucial
role
programmed
cell
death
(PCD)
regulating
NPCs.
Aims
This
review
aimed
elucidate
various
forms
PCD
their
respective
roles
IDD,
investigate
diverse
targeting
treatment.
Materials
&
Methods
We
collected
relevant
literature
regarding
development
Subsequently,
we
comprehensively
summarized
intricate
association
between
also
explored
potential
application
therapy
traditional
Chinese
medicine
(TCM)
prevention
treatment
Results
Current
indicated
that
was
Additionally,
targeted
pharmaceuticals
based
on
mechanisms
could
effectively
impede
loss
Conclusion
demonstrated
may
be
promising
strategy
