Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Dec. 18, 2024
PCAT19,
a
long
non-coding
RNA,
has
attracted
considerable
attention
due
to
its
diverse
roles
in
various
malignancies.
This
work
compiles
current
research
on
PCAT19’s
involvement
cancer
pathogenesis
and
progression.
Abnormal
expression
of
PCAT19
been
observed
cancers,
correlation
with
clinical
features
prognosis
positions
it
as
promising
prognostic
biomarker.
Additionally,
ability
effectively
differentiate
between
tumor
normal
tissues
suggests
significant
diagnostic
value.
exhibits
dual
nature,
functioning
either
an
oncogene
or
suppressor,
depending
the
type.
It
is
implicated
range
tumor-related
activities,
including
cell
proliferation,
apoptosis,
invasion,
migration,
metabolism,
well
growth
metastasis.
acts
competing
endogenous
RNA
(ceRNA)
interacts
proteins
regulate
critical
cancer-related
pathways,
such
MELK
signaling,
p53
cycle
pathways.
Furthermore,
emerging
evidence
that
plays
role
modulation
neuropathic
pain,
adding
complexity
functional
repertoire.
By
exploring
molecular
mechanisms
pathways
associated
we
aim
provide
comprehensive
understanding
multifaceted
human
health
disease,
highlighting
potential
therapeutic
target
for
pain
management.
BMC Medical Genomics,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Aug. 14, 2024
Non-coding
RNA
expression
has
shown
to
have
cell
type-specificity.
The
regulatory
characteristics
of
these
molecules
are
impacted
by
changes
in
their
levels.
We
performed
next-generation
sequencing
and
examined
small
RNA-seq
data
obtained
from
6
different
types
blood
cells
separated
fluorescence-activated
sorting
severe
COVID−19
patients
healthy
control
donors.
In
addition
examining
the
behavior
piRNA
SARS-CoV−2
infected
patients,
our
aim
was
present
a
distinct
differential
portrait
for
each
separate
type.
observed
that
depending
on
type
cell,
sorted
(erythrocytes,
monocytes,
lymphocytes,
eosinophils,
basophils,
neutrophils)
altering
patterns.
After
analyzing
piRNAs
set
with
COVID−19,
we
3
significantly
elevated
-
piR−33,123,
piR−34,765,
piR−43,768
9
downregulated
erythrocytes.
all
19
were
upregulated.
Monocytes
presented
larger
amount
statistically
significant
piRNA,
5
upregulated
(piR−49039
piR−31623,
piR−37213,
piR−44721,
piR−44720)
35
downregulated.
It
been
previously
piR−31,623
associated
respiratory
syncytial
virus
infection,
taking
account
major
role
transposon
silencing,
presume
patterns
which
could
be
signal
indirect
antiviral
activity
or
specific
state.
Additionally,
Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(9), P. 2342 - 2342
Published: Sept. 19, 2023
COVID-19,
a
disease
caused
by
the
SARS-CoV-2
virus,
poses
significant
threats
to
respiratory
system
and
other
vital
organs.
Long
non-coding
RNAs
have
emerged
as
influential
epigenetic
regulators
promising
biomarkers
in
ailments.
The
objective
of
this
study
was
identify
candidate
lncRNAs
SARS-CoV-2-positive
individuals
compared
SARS-CoV-2-negative
investigate
their
potential
association
with
ARDS-CoV-2
(acute
distress
syndrome).
Employing
qRT-PCR,
we
meticulously
examined
expression
profiles
panel
comprising
84
inflammation-related
presenting
upper
infection
symptoms,
categorizing
them
into
those
testing
negative
or
positive
for
SARS-CoV-2.
Notably,
first-phase
PSD
exhibited
significantly
elevated
levels
AC000120.7
SENP3-EIF4A1.
In
addition,
measured
two
lncRNAs,
SENP3-EIF4A1,
patients
ARDS
unrelated
(n
=
5)
induced
(ARDS-CoV-2,
n
10),
interestingly,
also
higher
among
ARDS.
Intriguingly,
our
interaction
pathway
analysis
unveiled
interactions
between
lncRNA
AC000120.7,
various
microRNAs,
genes
associated
inflammation.
This
found
SENP3-EIF4A1
context
infection-positive
particularly
within
complex
landscape
Long
COVID,
also
known
as
post-acute
sequelae
of
SARS-CoV-2
infection
(PASC),
has
emerged
a
significant
health
concern
following
the
COVID-19
pandemic.
Molecular
mechanisms
underlying
occurrence
and
progression
long
COVID
include
viral
persistence,
immune
dysregulation,
endothelial
dysfunction,
neurological
involvement,
highlight
need
for
further
research
to
develop
targeted
therapies
this
condition.
While
clearer
picture
clinical
symptomatology
is
shaping,
many
molecular
are
yet
be
unraveled,
given
their
complexity
high
level
interaction
with
other
metabolic
pathways.
This
review
summarizes
some
most
important
symptoms
associated
that
occur
in
well
relevant
techniques
can
used
understanding
pathogen,
its
affinity
towards
host
possible
outcomes
host-pathogen
interaction.
Archives of Insect Biochemistry and Physiology,
Journal Year:
2024,
Volume and Issue:
115(1)
Published: Jan. 1, 2024
Abstract
Bombyx
mori
bidensovirus
(BmBDV)
is
one
of
the
most
important
pathogens
silkworm.
It
mainly
infects
midgut
cells
silkworm
and
causes
losses
to
sericulture
industry.
Long
noncoding
RNAs
(lncRNAs)
have
been
reported
play
an
role
in
regulation
antiviral
immune
response
To
explore
whether
lncRNAs
are
involved
BmBDV
infection
silkworm,
we
performed
a
comparative
transcriptome
analysis
identify
mRNAs
between
infected
noninfected
larvae
at
early
stage.
A
total
16,069
genes
974
candidate
were
identified,
among
which
142
messenger
RNA
(mRNAs)
four
differentially
expressed
(DE).
Target
gene
prediction
revealed
that
DEmRNAs
coexpressed
with
DElncRNAs,
suggesting
expression
mRNA
affected
through
trans
‐regulation
activities.
regulatory
network
DElncRNAs
was
constructed,
showing
many
targeted
by
different
metabolism
immunity,
implies
these
replication
BmBDV.
Our
results
will
help
us
improve
our
understanding
lncRNA‐mediated
roles
infection,
providing
new
perspective
for
further
exploring
interaction
host
Physiological
condition
and
cell
type
have
a
major
impact
on
non-coding
RNA
expression.
These
molecules'
regulatory
characteristics
are
impacted
by
changes
in
We
examined
RNA-seq
data
from
sorted
blood
cells
of
severe
COVID-19
patients
as
well
healthy
control
donors.
In
addition
to
examining
the
behavior
piRNA
patients,
our
goals
were
present
distinct
differential
expression
portrait
for
each
separate
type.
Depending
cell,
different
(erythrocytes,
monocytes,
lymphocytes,
eosinophils,
basophils,
neutrophils)
overall
patterns.
After
analyzing
piRNAs
set
with
COVID-19,
we
found
that
three
elevated
ten
downregulated
erythrocytes.
all
19
upregulated.
Monocytes
presented
larger
amount
statistically
significant
piRNA,
4
upregulated
35
downregulated.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Dec. 18, 2024
PCAT19,
a
long
non-coding
RNA,
has
attracted
considerable
attention
due
to
its
diverse
roles
in
various
malignancies.
This
work
compiles
current
research
on
PCAT19’s
involvement
cancer
pathogenesis
and
progression.
Abnormal
expression
of
PCAT19
been
observed
cancers,
correlation
with
clinical
features
prognosis
positions
it
as
promising
prognostic
biomarker.
Additionally,
ability
effectively
differentiate
between
tumor
normal
tissues
suggests
significant
diagnostic
value.
exhibits
dual
nature,
functioning
either
an
oncogene
or
suppressor,
depending
the
type.
It
is
implicated
range
tumor-related
activities,
including
cell
proliferation,
apoptosis,
invasion,
migration,
metabolism,
well
growth
metastasis.
acts
competing
endogenous
RNA
(ceRNA)
interacts
proteins
regulate
critical
cancer-related
pathways,
such
MELK
signaling,
p53
cycle
pathways.
Furthermore,
emerging
evidence
that
plays
role
modulation
neuropathic
pain,
adding
complexity
functional
repertoire.
By
exploring
molecular
mechanisms
pathways
associated
we
aim
provide
comprehensive
understanding
multifaceted
human
health
disease,
highlighting
potential
therapeutic
target
for
pain
management.
