Hyperuricemia and its related diseases: mechanisms and advances in therapy

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 28, 2024

Abstract Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a spectrum commodities such as gout, cardiovascular diseases, renal disorders, metabolic syndrome, and diabetes, etc. Significantly impairing the quality life for those affected, prevalence hyperuricemia an upward trend globally, especially in most developed countries. UA possesses multifaceted role, antioxidant, pro-oxidative, pro-inflammatory, nitric oxide modulating, anti-aging, immune effects, which are significant both physiological pathological contexts. The equilibrium circulating urate hinges on interplay between production excretion, delicate balance orchestrated transporter functions across various epithelial tissues cell types. While existing research has identified involvement numerous biological processes signaling pathways, precise mechanisms connecting disease etiology remain be fully elucidated. In addition, influence genetic susceptibilities environmental determinants calls detailed nuanced examination. This review compiles data from global epidemiological studies clinical practices, exploring foundations transporters depth. Furthermore, we uncover complex induced inflammation influences individuals with association its relative disease, offering foundation innovative therapeutic approaches advanced pharmacological strategies.

Language: Английский

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The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

Carbohydrates, lipids, bile acids, various inorganic salt ions and organic acids are the main nutrients or indispensable components of human body. Dysregulation in processes absorption, transport, metabolism, excretion these metabolites can lead to onset severe metabolic disorders, such as type 2 diabetes, non-alcoholic fatty liver disease, gout hyperbilirubinemia. As second largest membrane receptor supergroup, several major families solute carrier (SLC) supergroup have been found play key roles transport substances carbohydrates, urate, monocarboxylates zinc ions. Based on common dysregulation related substances, we explored relationship between SLC diseases, providing examples drugs targeting proteins that approved currently clinical/preclinical research well SLC-related diagnostic techniques clinical use under investigation. By highlighting connections, aim provide insights may contribute development improved treatment strategies targeted therapies for disorders.

Language: Английский

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Single Nucleotide Variants of the SLC2A9 Gene are Associated With Hyperuricemia in Mexican Patients With Type 2 Diabetes

Archives of Medical Research, Journal Year: 2025, Volume and Issue: 56(6), P. 103235 - 103235

Published: May 14, 2025

Language: Английский

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Integrating Network Pharmacology and Metabolomics to Explore the Potential Mechanism of β‐Sitosterol Against Hyperuricemia Nephropathy

Journal of Food Biochemistry, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Background: Renal involvement resulting from hyperuricemia, known as hyperuricemia nephropathy (HN), is characterized by chronic tubulointerstitial inflammation caused extensive urate crystal deposition. Managing this condition requires straightforward preventive or therapeutic interventions, primarily through dietary measures. Methods: In study, the mouse model of HN was established using yeast extract combined with potassium oxonate. The effect and potential mechanism β‐sitosterol in treating were investigated biochemical indexes, pathological changes, untargeted metabolomics, network pharmacology. Results: β‐Sitosterol reduced levels four biomarkers HN: uric acid (UA), creatinine (CRE), blood urea nitrogen (BUN), xanthine oxidase (XOD). It also mitigated inflammatory injury renal tissues reversed abnormal expression key transporter proteins: glucose protein 9 (GLUT9), organic anion 1 (OAT1), ATP‐binding cassette G2 (ABCG2), (URAT1). To explore HN, study employed pharmacology metabolomics to analyze 27 intersecting gene targets 14 differential metabolites. findings indicated that glutathione (GSH) metabolism might be a crucial pathway. Treatment increased GSH well activity 6‐phosphogluconate dehydrogenase (G6PDH) mice, thereby effectively modulating metabolism. This proposes novel strategy for providing promising approach addressing condition.

Language: Английский

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Mechanism of intestinal flora affecting SLC2A9 transport function to promote the formation of hyperuricemia

Heliyon, Journal Year: 2024, Volume and Issue: 10(23), P. e40597 - e40597

Published: Nov. 29, 2024

Language: Английский

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Hyperuricemia and epiretinal pathologies: a review of pathophysiological links and clinical implications

Exploration of Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 732 - 749

Published: Oct. 31, 2024

Hyperuricemia (HUA), defined by elevated serum uric acid levels, is well-established in its association with systemic conditions like gout and cardiovascular diseases. Recently, however, emerging research has revealed a potential connection between HUA ocular disorders, particularly epiretinal pathologies. This review investigates the pathophysiological mechanisms linking to conditions, including membrane formation, macular edema, retinal vascular By thoroughly analyzing current literature, this seeks deepen understanding of relationship aim informing new therapeutic strategies enhancing patient outcomes.

Language: Английский

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