Free Radical Research,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 13
Published: Dec. 8, 2024
Urban
aerosol
particulate
matter
(UPM)
is
widespread
in
the
environment,
and
its
concentration
continues
to
increase.
Several
recent
studies
have
reported
that
UPM
results
premature
cellular
senescence,
but
few
investigated
molecular
basis
of
UPM-induced
senescence
retinal
pigment
epithelial
(RPE)
cells.
In
this
study,
we
primarily
evaluated
protective
function
nuclear
factor
erythroid
2-related
2
(Nrf2)
human
RPE
ARPE-19
The
findings
indicated
exposure
substantially
induced
cells,
as
observed
by
increased
β-galactosidase
activity,
expression
levels
senescence-associated
marker
proteins,
phenotypes.
Such
associated
with
mitochondrial
oxidative
stress-mediated
phosphatidylinositol
3'-kinase/Akt/Nrf2
downregulation.
Sulforaphane-mediated
Nrf2
activation
upregulation
phosphorylated
suppressed
decrease
target
antioxidant
gene,
NAD(P)H
quinone
oxidoreductase
1,
under
UPM,
which
notably
prevented
cells
from
senescence.
By
contrast,
knockdown
exacerbated
promoted
stress.
Collectively,
our
demonstrate
regulatory
role
suggest
a
potential
target.
Drug Design Development and Therapy,
Journal Year:
2024,
Volume and Issue:
Volume 18, P. 2485 - 2529
Published: June 1, 2024
Abstract:
Ferroptosis,
a
unique
form
of
programmed
cell
death,
is
initiated
by
an
excess
iron
accumulation
and
lipid
peroxidation-induced
damage.
There
growing
body
evidence
indicating
that
ferroptosis
plays
critical
role
in
the
advancement
tumors.
The
increased
metabolic
activity
higher
levels
tumor
cells
make
them
particularly
vulnerable
to
ferroptosis.
As
result,
targeted
induction
becoming
increasingly
promising
approach
for
cancer
treatment.
This
review
offers
overview
regulatory
mechanisms
ferroptosis,
delves
into
mechanism
action
traditional
small
molecule
inducers
their
effects
on
various
In
addition,
latest
progress
inducing
using
new
means
such
as
proteolysis-targeting
chimeras
(PROTACs),
photodynamic
therapy
(PDT),
sonodynamic
(SDT)
nanomaterials
summarized.
Finally,
this
discusses
challenges
opportunities
development
ferroptosis-inducing
agents,
focusing
discovering
targets,
improving
selectivity,
reducing
toxic
side
effects.
Keywords:
inducers,
molecules,
PROTACs,
PDT,
SDT,
NanoImpact,
Journal Year:
2024,
Volume and Issue:
34, P. 100508 - 100508
Published: April 1, 2024
The
objective
of
this
investigation
was
to
evaluate
the
influence
micro-
and
nanoplastic
particles
composed
polyethylene
terephthalate
(PET),
a
significant
contributor
plastic
pollution,
on
human
brain
vascular
pericytes.
Specifically,
we
delved
into
their
impact
mitochondrial
functionality,
oxidative
stress,
expression
genes
associated
with
ferroptosis
functions.
Our
findings
demonstrate
that
exposure
monoculture
pericytes
PET
in
vitro
at
concentration
50
μg/ml
for
duration
3,
6
10
days
did
not
elicit
stress.
Notably,
observed
reduction
various
aspects
respiration,
including
maximal
spare
respiratory
capacity,
ATP
production
subjected
3
days,
function
recovery
days.
Furthermore,
there
were
no
statistically
alterations
DNA
copy
number,
or
linked
stress
ferroptosis,
but
an
increase
gene
transcription
factor
A
(TFAM)
noted
exposure.
These
outcomes
suggest
that,
μg/ml,
do
induce
Instead,
exposure,
impairs
functions,
is
recovered
6-day
This
seems
indicate
potential
hormesis
response
(mitohormesis)
incited,
involving
TFAM.
Further
investigations
are
warranted
explore
stages
mitohormesis
consequences
plastics
integrity
blood-brain
barrier
intercellular
interactions.
research
contributes
our
comprehension
repercussions
pollution
health
underscores
imperative
need
ongoing
examinations
particles.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Aug. 20, 2024
Specific
protein
1
(Sp1)
is
central
to
regulating
transcription
factor
activity
and
cell
signaling
pathways.
Sp1
highly
associated
with
the
poor
prognosis
of
various
cancers;
it
considered
a
non-oncogene
addiction
gene.
The
function
complex
contributes
extensive
transcriptional
activity,
apart
from
maintaining
basal
transcription.
stability
are
affected
by
post-translational
modifications
(PTMs),
including
phosphorylation,
ubiquitination,
acetylation,
glycosylation,
SUMOylation.
These
help
determine
genetic
programs
that
alter
structure
in
different
cells
increase
or
decrease
its
DNA
binding
response
pathophysiological
stimuli.
Investigating
PTMs
will
contribute
deeper
understanding
mechanism
underlying
pathway
regulatory
which
affects
cancer
progression.
Furthermore,
facilitate
development
new
drug
targets
biomarkers,
thereby
elucidating
considerable
implications
prevention
treatment
cancer.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(5), P. 540 - 540
Published: April 30, 2024
Hydrogen
sulfide
(H2S),
previously
regarded
as
a
toxic
exhaust
and
atmospheric
pollutant,
has
emerged
the
third
gaseous
signaling
molecule
following
nitric
oxide
(NO)
carbon
monoxide
(CO).
Recent
research
revealed
significant
biological
effects
of
H2S
in
variety
systems,
such
nervous,
cardiovascular,
digestive
systems.
Additionally,
been
found
to
impact
reproductive
system
function
may
have
therapeutic
implications
for
disorders.
This
paper
explores
relationship
between
male
disorders,
specifically
erectile
dysfunction,
prostate
cancer,
infertility,
testicular
damage.
it
examines
regulation
on
pathophysiology
female
system,
including
improvements
preterm
birth,
endometriosis,
pre-eclampsia,
fetal
growth
restriction,
unexplained
recurrent
spontaneous
abortion,
placental
oxidative
damage,
embryo
implantation,
recovery
myometrium
post-delivery,
ovulation.
The
study
delves
into
regulatory
functions
within
systems
both
genders,
its
NO/cGMP
pathway,
activation
K+
channels,
relaxation
mechanism
spongy
smooth
muscle
through
ROCK
aiming
broaden
scope
potential
strategies
treating
disorders
clinical
settings.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 30, 2024
As
an
important
gas
signaling
molecule,
hydrogen
sulfide
(H
2
S)
affects
multiple
organ
systems,
including
the
nervous,
cardiovascular,
digestive,
and
genitourinary,
reproductive
systems.
In
particular,
H
S
not
only
regulates
female
function
but
also
holds
great
promise
in
treatment
of
male
diseases
disorders,
such
as
erectile
dysfunction,
prostate
cancer,
varicocele,
infertility.
this
review,
we
summarize
relationship
between
organs,
penis,
testis,
prostate,
vas
deferens,
epididymis.
lower
urinary
tract
symptoms
have
a
significant
impact
on
penile
erection
address
potential
ameliorative
effects
dysfunction
resulting
from
bladder
disease.
Additionally,
discuss
regulatory
role
cavernous
smooth
muscle
relaxation,
which
involves
NO/cGMP
pathway,
RhoA/Rho-kinase
K
+
channel
activation.
Recently,
various
compounds
that
can
alleviate
been
reported
to
be
at
least
partly
dependent
S.
Therefore,
understanding
system
may
help
develop
novel
strategies
for
clinical
diseases.
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(7), P. 7147 - 7168
Published: July 7, 2024
Acute
lung
injury
(ALI)
and
its
most
severe
form,
acute
respiratory
distress
syndrome
(ARDS),
are
pulmonary
conditions
that
cause
significant
morbidity
mortality.
The
common
etiologies
of
these
include
pneumonia,
contusion,
fat
embolism,
smoke
inhalation,
sepsis,
shock,
pancreatitis.
Inflammation,
oxidative
stress,
apoptosis,
autophagy
key
pathophysiological
mechanisms
underlying
ALI.
Hydrogen
sulfide
(H
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(17), P. 2996 - 2996
Published: Sept. 5, 2024
Multiple
sclerosis
(MS)
is
a
chronic
autoimmune
disorder
characterized
by
inflammation,
demyelination,
and
neurodegeneration,
resulting
in
significant
disability
reduced
quality
of
life.
Current
therapeutic
strategies
primarily
target
immune
dysregulation,
but
limitations
efficacy
tolerability
highlight
the
need
for
alternative
treatments.
Plant-derived
compounds,
including
alkaloids,
phenylpropanoids,
terpenoids,
have
demonstrated
anti-inflammatory
effects
both
preclinical
clinical
studies.
By
modulating
responses
promoting
neuroregeneration,
these
compounds
offer
potential
as
novel
adjunctive
therapies
MS.
This
review
provides
insights
into
molecular
cellular
basis
MS
pathogenesis,
emphasizing
role
inflammation
disease
progression.
It
critically
evaluates
emerging
evidence
supporting
use
plant-derived
to
attenuate
symptomology.
In
addition,
we
provide
comprehensive
source
information
detailing
known
mechanisms
action
assessing
context
with
focus
on
their
neuroprotective
properties.
