The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure DOI Creative Commons
Dandan Guo, Jianjun Yan, Zhenyu Yang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

Heart failure (HF) is a complex and debilitating condition characterized by the heart's inability to pump blood effectively, leading significant morbidity mortality. The abnormality of immune response key factor in progression HF, contributing adverse cardiac remodeling dysfunction. Exosomal microRNAs (miRNAs) play pivotal role regulating gene expression cellular function, which are integral crosstalk between cells, influencing cell functions, such as macrophage polarization, T activity, cytokine production, thereby modulating various pathological processes inflammation, fibrosis, This review emphasizes immune-regulatory exosomal miRNAs HF highlights their clinical potential diagnostic biomarkers therapeutic agents.

Language: Английский

Emerging role of exosomes in cancer therapy: progress and challenges DOI Creative Commons
Jiale Li,

Jiachong Wang,

Zigui Chen

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 13, 2025

This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple types. As small extracellular vesicles, exosomes exhibit high biocompatibility low immunogenicity, making them ideal vehicles capable of efficiently targeting cells, minimizing off-target damage side effects. aims to explore the potential with a focus on applications chemotherapy, gene immunomodulation. Additionally, challenges related production standardization are analyzed, highlighting importance addressing these issues clinical application. In conclusion, systems offer promising future therapies. Further research should aim enhance efficiency facilitate translation, paving way innovative treatment strategies.

Language: Английский

Citations

10
Reducing M2 macrophage in lung fibrosis by controlling anti-M1 agent DOI Creative Commons

Fatemeh Bahram Yazdroudi,

Alaeddin Malek

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 3, 2025

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by excessive scarring and due to the abnormal accumulation of extracellular matrix components, primarily collagen. This study aims design solve an optimal control problem regulate M2 macrophage activity in IPF, thereby preventing formation controlling anti-M1 agent. The research models diffusion macrophages inflamed tissue using novel dynamical system with partial differential equation (PDE) constraints. formulated minimize regulating employs two-step process discretization followed optimization, utilizing Galerkin spectral method transform PDE into algebraic ordinary equations (ODEs). then solved Pontryagin/s minimum principle, canonical Hamiltonian equations, extended Riccati equations. numerical simulations indicate that without control, levels increase stabilize, contributing fibrosis. In contrast, strategy effectively reduces macrophages, within 120 days. results highlight potential proposed approach modulating repair processes mitigating progression IPF. underscores significance targeting employing mathematical methods develop innovative therapies for

Language: Английский

Citations

0
Engineering Macrophage‐Derived Exosome to Deliver Pirfenidone: A Novel Approach to Combat Silicotic Pulmonary Fibrosis DOI
Zhen Chen, Yun Xiang, Jiaqi Tian

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)

Published: Oct. 9, 2024

Silicosis is a severe lung disease characterized by diffuse pulmonary fibrosis, for which there currently no effective treatment. Pirfenidone (PFD) shows great antifibrotic potential but clinically hindered low bioavailability and gastrointestinal side effects. To address these limitations, this study develops PFD delivery system (PFD-Exo) using J774A.1 macrophage-derived exosomes. Firstly, loaded via sonication, then PFD-Exo Raman spectral imaging UV absorption spectroscopy. Finally, in vitro vivo silicosis models are established to evaluate its Results show that outperforms free inhibiting TGF-β1-induced transdifferentiation of primary fibroblasts vitro. In mouse model silicosis, found be accumulated the lungs following intratracheal administration significantly ameliorates inflammation fibrosis while minimizing Mechanistic studies reveal modulates TGF-β signaling pathway downregulating SMAD3 upregulating SMAD7 NOGGIN. conclusion, provides first evidence exosomes as an treatment offers promising strategy other refractory diseases.

Language: Английский

Citations

1
The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure DOI Creative Commons
Dandan Guo, Jianjun Yan, Zhenyu Yang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

Heart failure (HF) is a complex and debilitating condition characterized by the heart's inability to pump blood effectively, leading significant morbidity mortality. The abnormality of immune response key factor in progression HF, contributing adverse cardiac remodeling dysfunction. Exosomal microRNAs (miRNAs) play pivotal role regulating gene expression cellular function, which are integral crosstalk between cells, influencing cell functions, such as macrophage polarization, T activity, cytokine production, thereby modulating various pathological processes inflammation, fibrosis, This review emphasizes immune-regulatory exosomal miRNAs HF highlights their clinical potential diagnostic biomarkers therapeutic agents.

Language: Английский

Citations

0