Whole transcriptome and proteome analyses identify ncRNAs and mRNAs to predict competing endogenous RNA networks in hepatitis B virus-induced hepatocellular carcinoma DOI
Shaoying Yan, Peng Fu,

Yali Zhu

et al.

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: unknown, P. 107248 - 107248

Published: Dec. 1, 2024

Language: Английский

hsa_circ_0088196 Predicts Adverse Pregnancy Outcomes in Preeclampsia Patients and Contributes to Endothelial Cell Injury Via Modulating the miR-145-5p/FLT1 Axis DOI

Yuelai Yang,

Lei Jiang,

Ruijing Chang

et al.

Reproductive Sciences, Journal Year: 2024, Volume and Issue: 31(12), P. 3825 - 3833

Published: Aug. 12, 2024

Language: Английский

Citations

0
LINC01094: A Key Long Non-Coding RNA in the Regulation of Cancer Progression and Therapeutic Targets DOI Creative Commons

Qiang Yi,

Gangfeng Zhu,

Weijian Zhu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e37527 - e37527

Published: Sept. 1, 2024

LINC01094 is a long non-coding RNA that plays crucial role in cancer progression by modulating key signaling pathways, such as PI3K/AKT, Wnt/β-catenin and TGF-β Signaling Pathway Feedback Loop. In this review we summarize the recent research on functional mechanisms of various cancers, including its impact tumor growth, metastasis, resistance to therapy. We also discuss therapeutic potential targeting highlight current strategies challenges area. Perspectives future development LINC01094-based therapies are provided.

Language: Английский

Citations

0
lncRNA NEAT1 affects granulosa cell apoptosis and steroid biosynthesis via the miR-204-5p/ESR1 axis in ovarian aging DOI Creative Commons
Li Dong, Haicui Wu,

Fanghua Qi

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Long non-coding RNAs (lncRNAs) play an important role in ovarian aging by affecting the biological functions of granulosa cells (GCs) through multiple mechanisms. The lncRNA NEAT1 is significantly downregulated ovaries; however, exact regulatory mechanism has not been elucidated. In current study, we aimed to investigate effects GC during and explore its therapeutic potential. We observed that expression GCs older patients with diminished reserve (DOR), which closely associated function assisted reproductive cycle outcomes. Functional assays revealed promotes KGN cell proliferation increasing proportion S-phase inhibiting apoptosis. Bioinformatics analysis a dual-luciferase reporter assay confirmed acts as miR-204-5p sponge identified ESR1 target gene, both were differentially expressed DOR. Mechanistic experiments demonstrated competitive endogenous RNA adsorbs molecular sponging, turn upregulates key enzymes (steroidogenic acute protein cytochrome P450 family 19 subfamily A member 1) involved steroid hormone synthesis. This induces estradiol biosynthesis activates downstream mitogen-activated kinase (MAPK) signaling pathway promote phosphorylation extracellular signaling-related cyclic adenosine monophosphate response element binding protein, affects results promotion inhibition apoptosis cells. Our suggest MAPK miR-204-5p/ESR1 axis; regulates proliferation, apoptosis, cycle; biosynthesis. Therefore, represents potential delay aging.

Language: Английский

Citations

0
PCAT19: the role in cancer pathogenesis and beyond DOI Creative Commons

Haijun Hu,

Hongliang Luo, Ziqing Deng

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 18, 2024

PCAT19, a long non-coding RNA, has attracted considerable attention due to its diverse roles in various malignancies. This work compiles current research on PCAT19’s involvement cancer pathogenesis and progression. Abnormal expression of PCAT19 been observed cancers, correlation with clinical features prognosis positions it as promising prognostic biomarker. Additionally, ability effectively differentiate between tumor normal tissues suggests significant diagnostic value. exhibits dual nature, functioning either an oncogene or suppressor, depending the type. It is implicated range tumor-related activities, including cell proliferation, apoptosis, invasion, migration, metabolism, well growth metastasis. acts competing endogenous RNA (ceRNA) interacts proteins regulate critical cancer-related pathways, such MELK signaling, p53 cycle pathways. Furthermore, emerging evidence that plays role modulation neuropathic pain, adding complexity functional repertoire. By exploring molecular mechanisms pathways associated we aim provide comprehensive understanding multifaceted human health disease, highlighting potential therapeutic target for pain management.

Language: Английский

Citations

0
Whole transcriptome and proteome analyses identify ncRNAs and mRNAs to predict competing endogenous RNA networks in hepatitis B virus-induced hepatocellular carcinoma DOI
Shaoying Yan, Peng Fu,

Yali Zhu

et al.

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: unknown, P. 107248 - 107248

Published: Dec. 1, 2024

Language: Английский

Citations

0