Stick to the Script: How Endomucin Keeps the Glycocalyx in Line

Circulation Research, Journal Year: 2025, Volume and Issue: 136(1), P. 75 - 77

Published: Jan. 2, 2025

Language: Английский

Uteroplacental microvascular remodeling in health and disease

Acta Physiologica, Journal Year: 2025, Volume and Issue: 241(5)

Published: March 29, 2025

The microvascular system is essential for delivering oxygen and nutrients to tissues while removing metabolic waste. During pregnancy, the uteroplacental undergoes extensive remodeling meet increased demands of fetus. Key adaptations include vessel dilation increases in vascular volume, density, permeability, all which ensure adequate placental perfusion maintaining stable maternal blood pressure. Structural functional abnormalities microvasculature are associated with various gestational complications, posing both immediate long-term risks health mother infant. In this review, we describe changes microvessels during discuss pathogenic mechanisms underlying diseases such as preeclampsia, fetal growth restriction, diabetes, summarize current clinical research approaches monitoring health. We also provide an update on models complications explore solutions several unresolved challenges. With advancements techniques, anticipate significant progress understanding managing these diseases, ultimately leading new therapeutic strategies improve

Language: Английский

Pulmonary Microvascular Endothelial Glycocalyx Degradation as a Key Driver in COPD Progression and Its Protection by Tongxinluo

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156878 - 156878

Published: May 1, 2025

Language: Английский