Antin-diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides: a review DOI Creative Commons
Xiaoli Liu,

Sailu Mao,

Yuxue Yuan

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 10, 2025

Diabetic cognitive dysfunction is one of the important comorbidities and complications diabetes, which mainly manifested by loss learning ability memory, behavioural disorders, may even develop into dementia. While traditional anti-diabetic medications are effective in improving cognition long-term use these can be accompanied undesirable side effects. Therefore, there an urgent need to find safe alternative therapies. Accumulating evidence suggests that phytogenic bioactive peptides play role regulation diabetes. In this review, we explored relationship between diabetes mellitus dysfunction, potential underlying mechanisms plant-derived improve diabetic dysfunction. We found active alleviate impairment inhibiting key enzymes (e.g., α-glucosidase, α-amylase) blood glucose levels increase antioxidant activity, modulate inflammatory mediators, address intestinal dysbiosis. conclusion, show strong impairment.

Language: Английский

Antin-diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides: a review DOI Creative Commons
Xiaoli Liu,

Sailu Mao,

Yuxue Yuan

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 10, 2025

Diabetic cognitive dysfunction is one of the important comorbidities and complications diabetes, which mainly manifested by loss learning ability memory, behavioural disorders, may even develop into dementia. While traditional anti-diabetic medications are effective in improving cognition long-term use these can be accompanied undesirable side effects. Therefore, there an urgent need to find safe alternative therapies. Accumulating evidence suggests that phytogenic bioactive peptides play role regulation diabetes. In this review, we explored relationship between diabetes mellitus dysfunction, potential underlying mechanisms plant-derived improve diabetic dysfunction. We found active alleviate impairment inhibiting key enzymes (e.g., α-glucosidase, α-amylase) blood glucose levels increase antioxidant activity, modulate inflammatory mediators, address intestinal dysbiosis. conclusion, show strong impairment.

Language: Английский

Citations

0