Cells, Journal Year: 2024, Volume and Issue: 13(20), P. 1726 - 1726

Published: Oct. 18, 2024

Hepatocellular carcinomas (HCCs) are highly heterogeneous malignancies. They characterized by a peculiar tumor microenvironment and dense vascularization. The importance of signaling between immune cells, endothelial cells leads to the difficult recapitulation reliable in vitro HCC model using conventional two-dimensional cell cultures. advent three-dimensional organoid technology has revolutionized our understanding pathogenesis progression several malignancies faithfully replicating original cancer genomic, epigenomic, microenvironmental landscape. Organoids more closely mimic vivo environment interactions, factors such as spatial organization surface receptors gene expression, will probably become an important tool choice therapies evaluation response treatments. This review aimed describe ongoing potential applications organoids for study development, its interaction with host's immunity, analysis drug sensitivity tests, current limits this field.

Language: Английский