Crosstalk between thyroid CSCs and immune cells: basic principles and clinical implications DOI Creative Commons

Xiaoxiao Li,

Hengtong Han,

Kaili Yang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 24, 2024

Thyroid cancer has become the most common endocrine malignancy. Although majority of differentiated thyroid cancers have a favorable prognosis, advanced cancers, iodine-refractory and highly malignant undifferentiated carcinomas still face serious challenge poor prognosis even death. Cancer stem cells are recognized as one central drivers tumor evolution, recurrence treatment resistance. A fresh viewpoint on oncological aspects cancer, including proliferation, invasion, recurrence, metastasis, therapeutic resistance, been made possible by recent thorough understanding defining developing features well plasticity (TCSCs). The above characteristics TCSCs complicated regulated cell-intrinsic mechanisms (including activation key signaling pathways, somatic cell dedifferentiation, etc.) cell-extrinsic mechanisms. complex communication between infiltrating immune populations in microenvironment (TME) is paradigm for regulators. This review introduces current advances studies TCSCs, origin intrinsic pathways regulating stemness emerging biomarkers; We further highlight underlying principles bidirectional crosstalk driving progression, or specific which maintain other properties how reshape microenvironmental landscape to create an evasive pro-tumorigenic ecological niche. Finally, we outline promising strategies challenges targeting programs TCSCs-immune process treat cancer.

Language: Английский

Oxidative Stress and Redox Imbalance: Common Mechanisms in Cancer Stem Cells and Neurodegenerative Diseases DOI Creative Commons

Nikhil Raj Selvaraj,

Durga Nandan,

B J Bipin Nair

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 511 - 511

Published: March 29, 2025

Oxidative stress (OS) is an established hallmark of cancer and neurodegenerative disorders (NDDs), which contributes to genomic instability neuronal loss. This review explores the contrasting role OS in stem cells (CSCs) NDDs. Elevated levels reactive oxygen species (ROS) contribute promote tumor initiation progression CSCs, while NDDs such as Alzheimer’s Parkinson’s disease, accelerates death impairs cellular repair mechanisms. Both scenarios involve disruption delicate balance between pro-oxidant antioxidant systems, leads chronic oxidative stress. Notably, CSCs neurons display alterations redox-sensitive signaling pathways, including Nrf2 NF-κB, influence cell survival, proliferation, differentiation. Mitochondrial dynamics further illustrate these differences: enhanced function supports adaptability whereas impairments heighten vulnerability. Understanding common mechanisms OS-induced redox imbalance may provide insights for developing interventions, addressing aging hallmarks, potentially mitigating or preventing both

Language: Английский

Citations

5
Impact of G1 phase kinetics on the acquisition of stemness in cancer cells: the critical role of cyclin D DOI
Yasin Ahmadi,

Tahran Faiq,

Sakhavat Abolhasani

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 14, 2025

Language: Английский

Citations

0
Photo-Activated Ferrocene-Iridium(III) Prodrug Induces Immunogenic Cell Death in Melanoma Stem Cells DOI

Qiaoshan Lie,

Hui Jiang, Xiangwan Lu

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Cancer stem cells (CSCs) are key contributors to tumor resistance, recurrence, and metastasis. Conventional chemotherapy often fails target eradicate CSCs, significantly impairing their therapeutic efficacy. Herein, we design synthesize a photoactivated ferrocene-iridium(III) complex (Ir-3) achieve immunotherapy against melanoma (including cells). In short, Ir-3 effectively targets mitochondria dissociates under light irradiation produce cytotoxic Ir(III) photosensitizer Fe2+ ions. They can generate reactive oxygen species by the Fenton reaction, robustly induce ferroptosis autophagy, eventually trigger immunogenic cell death in Furthermore, exposure, inhibits cell-related properties promotes macrophage-mediated phagocytosis of cells. For vivo studies, is encapsulated DSPE-PEG 2000 form tumor-targeting Ir-3@PEG nanoparticles. After photoactivation, inhibit primary distant tumors, stemness cells, innate adaptive immune responses.

Language: Английский

Citations

0
Bioinformatics-based analysis of fatty acid metabolic reprogramming in hepatocellular carcinoma: cellular heterogeneity, therapeutic targets, and drug discovery DOI Creative Commons
Guo Ying-ying, Run Shi, Yu Xu

et al.

Acta Materia Medica, Journal Year: 2024, Volume and Issue: 3(4)

Published: Jan. 1, 2024

Fatty acid (FA) reprogramming has a significant role in liver cancer. However, the contribution of FA metabolism to heterogeneity hepatocellular carcinoma (HCC) not been established. Bioinformatics analysis using single-cell sequencing, non-negative matrix factorization (NMF) algorithm, and survival analyses were used investigate HCC patients. Molecular targets progress drug discovery also analyzed discussed. Among 13 types cells, epithelial cells exhibited highest score for metabolic aberrance, while certain lymphocytes, such as B CD8Tcm Treg lowest score. Furthermore, displayed diversity with wide distribution range (−0.2 0.8). Additionally, low level was associated poor prognosis patients (log-rank test, P =0.0089). Higher oxidase expression correlated lower risk oncogenesis higher overall survival. enzymes involved synthesis, oxidation, storage, release considerable phenotypic HCC. reprograming shown be significantly HCC, which is characterized by cancerous enzymes.

Language: Английский

Citations

1
Crosstalk between thyroid CSCs and immune cells: basic principles and clinical implications DOI Creative Commons

Xiaoxiao Li,

Hengtong Han,

Kaili Yang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 24, 2024

Thyroid cancer has become the most common endocrine malignancy. Although majority of differentiated thyroid cancers have a favorable prognosis, advanced cancers, iodine-refractory and highly malignant undifferentiated carcinomas still face serious challenge poor prognosis even death. Cancer stem cells are recognized as one central drivers tumor evolution, recurrence treatment resistance. A fresh viewpoint on oncological aspects cancer, including proliferation, invasion, recurrence, metastasis, therapeutic resistance, been made possible by recent thorough understanding defining developing features well plasticity (TCSCs). The above characteristics TCSCs complicated regulated cell-intrinsic mechanisms (including activation key signaling pathways, somatic cell dedifferentiation, etc.) cell-extrinsic mechanisms. complex communication between infiltrating immune populations in microenvironment (TME) is paradigm for regulators. This review introduces current advances studies TCSCs, origin intrinsic pathways regulating stemness emerging biomarkers; We further highlight underlying principles bidirectional crosstalk driving progression, or specific which maintain other properties how reshape microenvironmental landscape to create an evasive pro-tumorigenic ecological niche. Finally, we outline promising strategies challenges targeting programs TCSCs-immune process treat cancer.

Language: Английский

Citations

0