PLoS neglected tropical diseases, Journal Year: 2024, Volume and Issue: 18(12), P. e0012673 - e0012673
Published: Dec. 11, 2024
Severe fever with thrombocytopenia syndrome (SFTS) is a rapidly progressive infectious disease triggered by novel bunyavirus (SFTSV). Despite the critical role of host lipid metabolism in viral infections, research on dyslipidemia SFTS remains limited.
Language: Английский
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 3295 - 3309
Published: March 1, 2025
Background: The systemic immune-inflammatory index (SII) serves as a comprehensive indication of inflammation. However, the relationship between SII and severity coronary artery lesions in participants with disease (CAD) different glucose metabolic states has not been fully elucidated. Methods: A total 2727 patients CAD were enrolled January 2018 April 2022. was calculated (platelet count × neutrophil count)/lymphocyte count. Participants grouped by quartiles. Glucose status classified normal regulation (NGR), pre-diabetes mellitus (Pre-DM) diabetes (DM) according to World Health Organization guidelines. Logistic regression restricted cubic spline models applied estimate further adjustments for confounders. Results: analysis indicated significant association lesion ( P < 0.05). Regardless status, highest quartile (Q4) had markedly higher risk severe than those lowest (Q1). After adjusting confounders, observed Pre-DM DM individuals 0.05), whereas NGR > Subgroup analyses revealed that consistent across age, gender, hypertension, antihypertensive drugs, hyperlipidemia, antilipidemic smokingand drinking Furthermore, modeling linear correlation severity. Conclusion: is relatively stable indicator inflammation positively correlated This study highlights potential novel inflammatory biomarker assessing among states. Keywords: immune-inflammation index, SII, heart disease, severity,
Language: Английский
Citations
0
Pathology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Optimal blood flow through a patent cerebral circulation is critical for supply of oxygen and nutrients brain function. The integrity vascular elements within arterial vessels any calibre can be compromised by various disease processes. Pathological changes in the walls veins venous system may also alter dynamics perfusion. consequences both systemic cerebrovascular diseases range from acute focal to irreversible chronic restructuring parenchyma. Cerebral infarcts different sizes instigate cascade programmed cell death mechanisms including autophagy mitophagy processes that necroptosis ferroptosis. Recent advances emphasise role inflammasome pathology infarction. Here, we summarise current knowledge on frequencies, epidemiological features neuropathology common disorders among which small vessel have become particular interest. We highlight spectrum monogenic polygenic genetic affecting intracranial vasculature. With advent DNA screening technologies, it now realised several exhibit strong traits. Whilst gene defects their aberrant products are identified, precise or how they influence angiogenesis, vasculogenesis, extracellular matrix remain largely unclear. Despite such advances, histopathological examination remains gold standard diagnosis characterisation most disorders.
Language: Английский
Citations
1
European Heart Journal - Cardiovascular Imaging, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 7, 2024
Abstract Inflammation is an important driver of disease in the context atherosclerosis, and several landmark trials have shown that targeting inflammatory pathways can reduce cardiovascular event rates. However, high cost potentially serious adverse effects anti-inflammatory therapies necessitate more precise patient selection. Traditional biomarkers inflammation, such as high-sensitivity C-reactive protein, show association with risk on a population level but do not specificity for local plaque inflammation. Nowadays, advancements non-invasive imaging vasculature enable direct assessment vascular Positron emission tomography (PET) tracers 18F-fluorodeoxyglucose detection metabolic activity cells are limited by low myocardial spillover effects. 18F-sodium fluoride tracer identifies active micro-calcification plaques, indicating vulnerable plaques. Gallium-68 DOTATATE targets pro-inflammatory macrophages binding to somatostatin receptors, which enhances Coronary computed angiography (CCTA) provides high-resolution images coronary arteries, identifying high-risk features. Measuring pericoronary adipose tissue attenuation CCTA represents novel marker This review examines both established emerging methods assessing atherosclerosis-related emphasizing role advanced refining stratification guiding personalized therapies. Integrating these modalities measurements systemic molecular could shift atherosclerotic management towards approach.
Language: Английский
Citations
1
PLoS neglected tropical diseases, Journal Year: 2024, Volume and Issue: 18(12), P. e0012673 - e0012673
Published: Dec. 11, 2024
Severe fever with thrombocytopenia syndrome (SFTS) is a rapidly progressive infectious disease triggered by novel bunyavirus (SFTSV). Despite the critical role of host lipid metabolism in viral infections, research on dyslipidemia SFTS remains limited.
Language: Английский
Citations
0