Protocol for engineering bone organoids from mesenchymal stem cells DOI
Jian Wang, Dongyang Zhou, Ruiyang Li

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 388 - 400

Published: Dec. 1, 2024

Language: Английский

Mechanisms of bone regeneration repair and potential and efficacy of small molecule drugs DOI
Ke Zhang,

Hao Li,

Tao Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118070 - 118070

Published: April 21, 2025

Language: Английский

Citations

0
Sequential Angiogenic-Osteogenic Coupling via a Spatiotemporally Graded Hydrogel Enables Vascularized Bone Organoids for Critical-Sized Calvarial Defect Reconstruction DOI

Xu Lou,

Fuxiao Wang,

Xia Lv

et al.

Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112553 - 112553

Published: April 1, 2025

Language: Английский

Citations

0
Intelligent Manufacturing for Osteoarthritis Organoids DOI Creative Commons
Xin Lyu, Jian Wang, Jiacan Su

et al.

Cell Proliferation, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

ABSTRACT Osteoarthritis (OA) is the most prevalent degenerative joint disease worldwide, imposing a substantial global burden. However, its pathogenesis remains incompletely understood, and effective treatment strategies are still lacking. Organoid technology, in which stem cells or progenitor self‐organise into miniature tissue structures under three‐dimensional (3D) culture conditions, provides promising vitro platform for simulating pathological microenvironment of OA. This approach can be employed to investigate mechanisms, carry out high‐throughput drug screening facilitate personalised therapies. review summarises structure, OA manifestations, thereby establishing context application organoid technology. It then examines components arthrosis system, specifically addressing cartilage, subchondral bone, synovium, skeletal muscle ligament organoids. Furthermore, it details various constructing organoids, including considerations cell selection, classification fabrication techniques. Notably, this introduces concept intelligent manufacturing organoids by incorporating emerging engineering technologies such as artificial intelligence (AI) process, forming an innovative software hardware cluster. Lastly, discusses challenges currently facing highlights future directions rapidly evolving field. By offering comprehensive overview state‐of‐the‐art methodologies challenges, anticipates that intelligent, automated will expedite fundamental research, discovery translational applications orthopaedic

Language: Английский

Citations

0
Protocol for engineering bone organoids from mesenchymal stem cells DOI
Jian Wang, Dongyang Zhou, Ruiyang Li

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 388 - 400

Published: Dec. 1, 2024

Language: Английский

Citations

3