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Cell Calcium, Journal Year: 2025, Volume and Issue: 126, P. 102999 - 102999

Published: Jan. 22, 2025

Language: Английский

The fundamental role of mitochondria–endoplasmic reticulum contacts in ageing and declining healthspan

Open Biology, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 1, 2025

This open question research article highlights mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), which have emerged as crucial cellular structures that challenge our traditional understanding of organelle function. review the critical importance MAMs a frontier in cell biology with far-reaching implications for health, disease and ageing. serve dynamic communication hubs between ER mitochondria, orchestrating essential processes such calcium signalling, lipid metabolism stress responses. Recent has implicated MAM dysfunction wide array conditions, including neurodegenerative diseases, metabolic disorders, cardiovascular diseases cancer. The significant lack biological knowledge behind function emphasizes need to study these enigmatic subcellular sites greater detail. Key questions include mechanisms controlling formation disassembly, full complement MAM-associated proteins how contribute decision-making ageing processes. Advancing through interdisciplinary approaches cutting-edge technologies promises reveal new insights into fundamental signalling pathways potentially lead innovative therapeutic strategies range diseases. As such, represents potential transform life human health.

Language: Английский

Cardioprotective effect of senotherapy in chronically obese middle-aged female rats may be mediated by a MERCSs/Nrf2 interaction.

The Journal of Nutritional Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109923 - 109923

Published: April 1, 2025

Language: Английский