Demystifying the Role of Histone Demethylases in Colorectal Cancer: Mechanisms and Therapeutic Opportunities DOI Creative Commons
Yuanbin Liu, Min Huang, Tian Xia

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 267 - 267

Published: April 9, 2025

Histone demethylases (HDMs) play a pivotal role in colorectal cancer (CRC) progression through dynamic epigenetic regulation. This review summarizes the and therapeutic potential of HDM CRC. HDMs primarily target lysine (K) for demethylation (lysine demethylase, KDM). The KDM family is divided into lysine-specific demethylase Jumonji C domain-containing family. complex roles CRC cell proliferation, invasion, migration, stemness, epithelial–mesenchymal transition, immune response, chemoresistance regulation different histone sites. Increasing evidence suggests that may interact with certain factors regulate tumorigenesis by modulating multiple signaling pathways affecting transcription genes. These processes be regulated upstream genes thus form regulatory network. However, mechanisms some remain understudied. Preclinical studies have revealed small-molecule inhibitors targeting impact activity specific inhibiting expression, thereby reshaping tumorigenic landscape clinical translational these remains unexplored. In conclusion, critical dynamically regulating methylation patterns. shape malignant behavior influencing key reprogramming. Targeting promising direction treatment. Further exploration HDM-specific needed future.

Language: Английский

Natural Alkaloids Modulating Macrophage Polarization: Innovative Therapeutic Strategies for Inflammatory, Cardiovascular, and Cancerous Diseases DOI
Jing Lü, Minghao Yin, Yixuan Song

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156709 - 156709

Published: April 1, 2025

Language: Английский

Citations

0
Demystifying the Role of Histone Demethylases in Colorectal Cancer: Mechanisms and Therapeutic Opportunities DOI Creative Commons
Yuanbin Liu, Min Huang, Tian Xia

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 267 - 267

Published: April 9, 2025

Histone demethylases (HDMs) play a pivotal role in colorectal cancer (CRC) progression through dynamic epigenetic regulation. This review summarizes the and therapeutic potential of HDM CRC. HDMs primarily target lysine (K) for demethylation (lysine demethylase, KDM). The KDM family is divided into lysine-specific demethylase Jumonji C domain-containing family. complex roles CRC cell proliferation, invasion, migration, stemness, epithelial–mesenchymal transition, immune response, chemoresistance regulation different histone sites. Increasing evidence suggests that may interact with certain factors regulate tumorigenesis by modulating multiple signaling pathways affecting transcription genes. These processes be regulated upstream genes thus form regulatory network. However, mechanisms some remain understudied. Preclinical studies have revealed small-molecule inhibitors targeting impact activity specific inhibiting expression, thereby reshaping tumorigenic landscape clinical translational these remains unexplored. In conclusion, critical dynamically regulating methylation patterns. shape malignant behavior influencing key reprogramming. Targeting promising direction treatment. Further exploration HDM-specific needed future.

Language: Английский

Citations

0