Fungal Bioactive Compounds as Emerging Therapeutic Options for Age-Related Neurodegenerative Disorders DOI Open Access
Valentina Bonetto, Alessandra Ferraresi,

Simonetta Sampò

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4800 - 4800

Published: May 16, 2025

Aging is a complex biological process characterized by progressive multiorgan deterioration that compromises the quality of life. Unhealthy aging often associates with cognitive decline and motor-neurological disorders including Alzheimer’s disease, Parkinson’s Huntington’s disease. Genetic, environmental, lifestyle factors, which include dietary habits, interact influence brain health, thus having an impact on development neurodegenerative disorders. In this context, fungal-derived bioactive compounds have emerged as promising neuroprotective agents due to their diverse properties antioxidative, anti-inflammatory, pro-autophagic, neurotrophic effects. Key fungal metabolites, polysaccharides, terpenoids, alkaloids, phenolic been shown modulate neuroinflammatory pathways, enhance neuronal survival, stimulate protective autophagy, promote synaptic plasticity. Still, challenges related bioavailability, standardization, clinical translation remain unresolved. Future deep research will be crucial unlocking full therapeutic potential compounds. This review examines role providing comparative evaluation focus mechanisms action in promoting health longevity.

Language: Английский

Actinomyces viscosus promotes neuroprotection in C. elegans models of Parkinson’s disease DOI Creative Commons

G Sophie Ngana,

Matteo Di Bernardo, Michael G. Surette

et al.

Mechanisms of Ageing and Development, Journal Year: 2025, Volume and Issue: unknown, P. 112061 - 112061

Published: April 1, 2025

Language: Английский

Citations

0
Fungal Bioactive Compounds as Emerging Therapeutic Options for Age-Related Neurodegenerative Disorders DOI Open Access
Valentina Bonetto, Alessandra Ferraresi,

Simonetta Sampò

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4800 - 4800

Published: May 16, 2025

Aging is a complex biological process characterized by progressive multiorgan deterioration that compromises the quality of life. Unhealthy aging often associates with cognitive decline and motor-neurological disorders including Alzheimer’s disease, Parkinson’s Huntington’s disease. Genetic, environmental, lifestyle factors, which include dietary habits, interact influence brain health, thus having an impact on development neurodegenerative disorders. In this context, fungal-derived bioactive compounds have emerged as promising neuroprotective agents due to their diverse properties antioxidative, anti-inflammatory, pro-autophagic, neurotrophic effects. Key fungal metabolites, polysaccharides, terpenoids, alkaloids, phenolic been shown modulate neuroinflammatory pathways, enhance neuronal survival, stimulate protective autophagy, promote synaptic plasticity. Still, challenges related bioavailability, standardization, clinical translation remain unresolved. Future deep research will be crucial unlocking full therapeutic potential compounds. This review examines role providing comparative evaluation focus mechanisms action in promoting health longevity.

Language: Английский

Citations

0