Oxidative Stress in Maternal and Offspring Kidney Disease and Hypertension: A Life-Course Perspective DOI Creative Commons

Pei‐Chen Lu,

You‐Lin Tain, Ying-Jui Lin

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 387 - 387

Published: March 26, 2025

Kidney disease and hypertension are interconnected, prevalent conditions that affect both pregnant women children. Oxidative stress occurs when reactive oxygen species or nitrogen exceed the capacity of antioxidant systems. It plays a critical role in kidney development, resulting programming increased risks for across life course. Animal models have significantly advanced our understanding oxidative stress-related programming, molecular mechanisms involved, early-life interventions to prevent disease. This review critically examines influence perinatal on highlighting its long-term effects outcomes susceptibility hypertension. also explores potential antioxidant-based preventing Furthermore, addresses existing gap between insights gained from animal their translation into clinical practices, emphasizing challenges opportunities future research this area.

Language: Английский

Oxidative Stress in Maternal and Offspring Kidney Disease and Hypertension: A Life-Course Perspective DOI Creative Commons

Pei‐Chen Lu,

You‐Lin Tain, Ying-Jui Lin

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 387 - 387

Published: March 26, 2025

Kidney disease and hypertension are interconnected, prevalent conditions that affect both pregnant women children. Oxidative stress occurs when reactive oxygen species or nitrogen exceed the capacity of antioxidant systems. It plays a critical role in kidney development, resulting programming increased risks for across life course. Animal models have significantly advanced our understanding oxidative stress-related programming, molecular mechanisms involved, early-life interventions to prevent disease. This review critically examines influence perinatal on highlighting its long-term effects outcomes susceptibility hypertension. also explores potential antioxidant-based preventing Furthermore, addresses existing gap between insights gained from animal their translation into clinical practices, emphasizing challenges opportunities future research this area.

Language: Английский

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