ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(46)
Published: Dec. 1, 2024
Abstract
Natural
surfactants
are
biodegradable
and
therefore
environmentally
benign.
To
avoid
the
detrimental
effects
of
synthetic
on
environment,
it
is
highly
desirable
to
replace
them
with
natural
as
alternatives.
In
this
context,
we
reporting
herein
use
saponins
derived
from
Indian
soapberry
(
Sapindus
mukorossi
)
fruit
pericarp
a
surfactant
for
synthesis
spiro[indoline‐3,4′‐pyran]‐2‐one
derivatives
through
one‐pot
three‐component
reaction
isatins,
malononitrile,
cyclic
1,3‐dicarbonyl
compounds.
Wide
substrate
scope
has
been
established
many
18
compounds
in
yields
ranging
72%
94%.
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
39(1)
Published: Dec. 10, 2024
ABSTRACT
This
work
investigated
the
use
of
a
complex
technique
including
isatoic
anhydrides,
α‐haloketones,
electron‐deficient
acetylenic
compounds,
ammonium
acetate,
and
isothiocyanates
in
water‐based
solution
at
normal
room
temperature
presence
SiO
2
/Fe
3
O
4
@Graphene
Oxide.
The
goal
was
to
generate
novel
thiazinoazepine
molecules
with
significant
yields.
thiazinoazepines
that
have
been
synthesized
contain
NH
functional
groups
acidic
protons
demonstrate
notable
antioxidant
activity.
(3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium
Bromide),
MTT
assay
utilized
evaluate
cytotoxicity
all
compounds
vitro
against
cancer
cell
lines
(MCF‐7
A549)
as
well
lines).
Cytotoxicity
refers
ability
compound
kill
cells.
derivative
6e
shown
be
most
potent
cytotoxic
agent,
similar
doxorubicin
its
lack
selectivity.
Alternatively,
6b
might
considered
is
equally
effective
but
more
selective
than
doxorubicin.
Quantum
chemical
approaches
utilizing
density
theory
enhance
comprehension
reaction
mechanisms.
used
technology
for
synthesizing
provides
several
advantages,
rapid
kinetics,
outstanding
product
yield,
straightforward
isolation.
