Nanoparticles of Natural Product-derived Medicines: Beyond the Pandemic

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42739 - e42739

Published: Feb. 1, 2025

This review explores the synergistic potential of natural products and nanotechnology for viral infections, highlighting key antiviral, immunomodulatory, antioxidant properties to combat pandemics caused by highly infectious viruses. These often result in severe public health crises, particularly affecting vulnerable populations due respiratory complications increased mortality rates. A cytokine storm is initiated when an overload pro-inflammatory cytokines chemokines released, leading a systemic inflammatory response. Viral mutations limited availability effective drugs, vaccines, therapies contribute continuous transmission virus. The coronavirus disease-19 (COVID-19) pandemic has sparked renewed interest product-derived antivirals. efficacy traditional medicines against infections examined. Their anti-inflammatory, are highlighted. discusses how enhances herbal combating infections.

Language: Английский

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Novel targeted pH-responsive drug delivery systems based on PEGMA-modified bimetallic Prussian blue analogs for breast cancer chemotherapy

RSC Advances, Journal Year: 2023, Volume and Issue: 13(3), P. 1684 - 1700

Published: Jan. 1, 2023

The development of novel nanoparticle-based drug delivery systems (nano-DDSs) with high loading capacity, low toxicity, precise targeting, and excellent biocompatibility remains urgent important for the treatment breast cancer (BC). Herein, BC-targeted nano-DDSs based on bimetallic Prussian blue analogs (PBA-DDSs) intracellular doxorubicin (DOX) pH-responsive release were developed. Two kinds PBA, namely CuFe (copper-iron) PBA CoFe (cobalt-iron) synthesized by a coprecipitation method, followed modification polyethyleneglycol methacrylate (PEGMA)

Language: Английский

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Injectable Nano Drug Delivery Systems for the Treatment of Breast Cancer

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(12), P. 2783 - 2783

Published: Dec. 13, 2022

Breast cancer is the most diagnosed type of cancer, with 2.26 million cases and 685,000 deaths recorded in 2020. If left untreated, this deadly disease can metastasize to distant organs, which reason behind its incurability related deaths. Currently, conventional therapies are used treat breast but they have numerous shortcomings such as low bioavailability, short circulation time, off-target toxicity. To address these challenges, nanomedicines preferred being extensively investigated for treatment. Nanomedicines novel drug delivery systems that improve stability, aqueous solubility, blood controlled release, targeted at tumoral site enhance therapeutic safety effectiveness. Nanoparticles (NPs) be administered through different routes. Although injectable route less than oral administration, it has advantages: helps tailor drugs moiety, boosts payload, avoids first-pass metabolism, improves pharmacokinetic parameters active pharmaceutical ingredients. Targeted nanomedicine, closer organelles mitochondria nuclei reduces dosage requirements toxic effects chemotherapeutics. This review aims provide current status recent advances various treatment cancer.

Language: Английский

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Tripterin liposome relieves severe acute respiratory syndrome as a potent COVID-19 treatment

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Dec. 24, 2022

Abstract For coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), 15–30% of patients are likely to develop COVID-19-related distress (ARDS). There still few effective and well-understood therapies available. Novel variants short-lasting immunity posing challenges vaccine efficacy, so finding antiviral antiinflammatory treatments remains crucial. Here, tripterin (TP), a traditional Chinese medicine, was encapsulated into liposome (TP lipo) investigate its effects in COVID-19. By using two COVID-19 models human ACE2-transgenic (hACE2) mice, an analysis TP lipo’s on pulmonary immune responses conducted. Pulmonary pathological alterations viral burden were reduced lipo treatment. inhibits SARS-CoV-2 replication hyperinflammation infected cells crucial events pathophysiology, it is promising drug candidate treat SARS-CoV-2-induced ARDS.

Language: Английский

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Smart Nanoparticles for Breast Cancer Treatment Based on the Tumor Microenvironment

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: May 26, 2022

Breast cancer (BC) is the most common malignant tumor in women. There are different risk characteristics and treatment strategies for subtypes of BC. The microenvironment (TME) great significance understanding occurrence, development, metastasis tumors. TME plays an important role all stages BC metastasis, immune monitoring, response avoidance, drug resistance, also diagnosis, prevention, prognosis Smart nanosystems have broad development prospect regulation delivery based on TME. In particular, TME-responsive nanoparticles cleverly utilize abnormal features tissues cells to achieve targeted transport, stable release, improved efficacy. We here present a review mechanisms underlying provide potential nanostrategies future treatment.

Language: Английский

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Nanomaterials in Animal Husbandry: Research and Prospects

Frontiers in Genetics, Journal Year: 2022, Volume and Issue: 13

Published: June 21, 2022

Anti-inflammatory, antiviral, and anti-cancer treatments are potential applications of nanomaterials in biology. To explore the latest discoveries nanotechnology, we reviewed published literature, focusing on co-assembled nanoparticles for anti-inflammatory anti-tumor properties, their animal husbandry. The results show that have significant anti-inflammation effects, demonstrating broad application prospects breeding. Furthermore, pooled evidence suggests mechanism is to a positive impact inflammation tumors through specific drug loading by indirectly or directly targeting disease sites. Because precise regulatory remains unclear, most studies focused regulating particular sites even genes nucleus functional nanoparticles. Hence, despite intriguing scenarios nanotechnology farmed animals, cannot yet be translated into field applications. Overall, outperformed similar materials terms anti-tumor. Nanotechnology also has promising husbandry veterinary care, its development remain an exciting area research.

Language: Английский

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Plausibility of natural immunomodulators in the treatment of COVID-19–A comprehensive analysis and future recommendations

Heliyon, Journal Year: 2023, Volume and Issue: 9(6), P. e17478 - e17478

Published: June 1, 2023

The COVID-19 pandemic has inflicted millions of deaths worldwide. Despite the availability several vaccines and some special drugs approved for emergency use to prevent or treat this disease still, there is a huge concern regarding their effectiveness, adverse effects, most importantly, efficacy against new variants. A cascade immune-inflammatory responses involved with pathogenesis severe complications COVID-19. People dysfunctional compromised immune systems display complications, including acute respiratory distress syndrome, sepsis, multiple organ failure etc., when they get infected SARS-CoV-2 virus. Plant-derived natural immune-suppressant compounds, such as resveratrol, quercetin, curcumin, berberine, luteolin, have been reported inhibit pro-inflammatory cytokines chemokines. Therefore, products immunomodulatory anti-inflammatory potential could be plausible targets contagious disease. This review aims delineate clinical trials status outcomes compounds in patients along

Language: Английский

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Repositioned Natural Compounds and Nanoformulations: A Promising Combination to Counteract Cell Damage and Inflammation in Respiratory Viral Infections

Molecules, Journal Year: 2023, Volume and Issue: 28(10), P. 4045 - 4045

Published: May 12, 2023

Respiratory viral diseases are among the most important causes of disability, morbidity, and death worldwide. Due to limited efficacy or side effects many current therapies increase in antiviral-resistant strains, need find new compounds counteract these infections is growing. Since development drugs a time-consuming expensive process, numerous studies have focused on reuse commercially available compounds, such as natural molecules with therapeutic properties. This phenomenon generally called drug repurposing repositioning represents valid emerging strategy discovery field. Unfortunately, use therapy has some limitations, due their poor kinetic performance consequently reduced effect. The advent nanotechnology biomedicine allowed this limitation be overcome, showing that nanoform may represent promising against respiratory infections. In narrative review, beneficial molecules, curcumin, resveratrol, quercetin, vitamin C, which been already studied both native form nanoform, presented discussed. review focuses ability analyzed vitro vivo studies, inflammation cellular damage induced by infection provide scientific evidence benefits nanoformulations increasing potential molecules.

Language: Английский

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Exploring the Impact of Herbal Therapies on COVID-19 and Influenza: Investigating Novel Delivery Mechanisms for Emerging Interventions

Biologics, Journal Year: 2023, Volume and Issue: 3(3), P. 158 - 186

Published: July 11, 2023

Synthetic antivirals and corticosteroids have been used to treat both influenza the SARS-CoV-2 disease named COVID-19. However, these medications are not always effective, produce several adverse effects, associated with high costs. Medicinal plants their constituents act on different targets signaling pathways involved in pathophysiology of This study aimed perform a review evaluate effects medicinal COVID-19, investigate potential delivery systems for new antiviral therapies. EMBASE, PubMed, GOOGLE SCHOLAR, COCHRANE databases were searched. The studies included this showed that plants, formulations, can help decrease viral spread time until full recovery. Plants reduced incidence acute respiratory syndromes symptom scores illnesses. Moreover, related few low In addition significance as natural agents, bioactive compounds may exhibit bioavailability. highlights need alternative systems, such metal nanoparticles, which effectively transport infected tissues.

Language: Английский

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Unveiling the Potential of Quercetin: Chemistry, Health Benefits, Toxicity, and Cutting-Edge Advances

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: June 13, 2024

Quercetin, a naturally occurring flavonoid, has gained significant attention in recent years due to its potential health benefits and versatile applications. This book chapter explores the chemistry of quercetin, shedding light on molecular structure, biosynthesis, extraction methods. The delves into extensive research effects highlighting antioxidant, anti-inflammatory, anticancer, neuroprotective, cardioprotective properties. Moreover, risks toxicity associated with quercetin consumption are thoroughly examined, emphasizing importance proper dosage drug interactions. concludes by providing an overview advances development, including nanoformulations, targeted delivery systems, combination therapies, that hold promise for enhancing therapeutic efficacy bioavailability. comprehensive exploration aims provide researchers, scientists, healthcare professionals valuable insights multifaceted nature applications human health.

Language: Английский

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