Metal–Organic Frameworks and Their Biodegradable Composites for Controlled Delivery of Antimicrobial Drugs

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 274 - 274

Published: Jan. 12, 2023

Antimicrobial resistance (AMR) is a growing global crisis with an increasing number of untreatable or exceedingly difficult-to-treat bacterial infections, due to their existing drugs. It predicted that AMR will be the leading cause death by 2050. In addition ongoing efforts on preventive strategies and infection control, there research towards development novel vaccines, antimicrobial agents, optimised diagnostic practices address AMR. However, developing new therapeutic agents medicines can lengthy process. Therefore, parallel worldwide effort develop materials for drug delivery improve efficacy minimise Examples such include functionalisation surfaces so they become self-disinfecting non-fouling, nanoparticles promising properties attributed ability damage numerous essential components pathogens. A relatively class materials, metal-organic frameworks (MOFs), also being investigated act as carriers because ultrahigh porosity modular structures, which engineered control mechanism loaded Biodegradable polymers have been found show applications carriers; and, recently, several studies reported drugs using composites MOF biodegradable polymers. This review article reflects MOFs polymer-MOF composites, drugs, studied provides overview state art in this highly topical area research.

Language: Английский

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Exploring the multifaceted roles of metal–organic frameworks in ecosystem regulation

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review provides a comprehensive analysis on the applications of various MOFs in both microbial eradication and protection, emphasizing their potential as promising smart materials field ecosystem regulation.

Language: Английский

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Microwave-assisted synthesis and development of novel penicillinoate@copper metal-organic frameworks as a potent antibacterial agent

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 11, 2024

Recently, nanoscience, especially metal-organic frameworks (MOFs), has been used to increase the effectiveness and properties of drugs. In this study, by using microwave irradiation; penicillin, which is a known antibiotic; copper (Cu-MOFs), new penicillinoate@copper framework (penicillinoate@Cu-MOF) was synthesized. The structure characterization newly synthesized compound were determined FT-IR spectrums, EDAX analysis, elemental XRD patterns, SEM images, nitrogen adsorption/desorption curves, TGA curve. Then, its antimicrobial effects evaluated on numerous Gram-positive Gram-negative bacterial strains compared with those penicillin gentamicin. continuation biological activities, antioxidant tests performed compounds DPPH method. For penicillinoate@Cu-MOF much more effective than Cu-MOF. loading nanostructure presence in final composition can be attributed high antibiotic composition.

Language: Английский

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Fabrication and Characterization of Novel Nanocomposite Containing Zn-MOF/Gentamicin/Oxidized Chitosan as a Highly Effective Antimicrobial Agent

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: 34(9), P. 4321 - 4331

Published: May 6, 2024

Language: Английский

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Microwave-assisted synthesis of novel Ti/BTB-MOFs as porous anticancer and antibacterial agents

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: May 13, 2024

Nano compounds, especially metal-organic frameworks (MOFs), have significant properties. Among the most important properties of these which depend on their specific surface area and porosity, are biological properties, such as anticancer antibacterial In this study, a new titanium/BTB framework (Ti/BTB-MOF) was synthesized by using titanium nitrate 1,3,5-Tris(4-carboxyphenyl)benzene (BTB) under microwave radiation. The structure Ti/BTB-MOF characterized confirmed X-ray diffraction (XRD) patterns, photoelectron spectroscopy (XPS) analysis, Fourier transform infrared (FT-IR) spectra, energy-dispersive (EDAX) analysis mapping, scanning electron microscope (SEM) images, thermogravimetric (TGA) curves, Brunauer-Emmett-Teller (BET) analysis.

Language: Английский

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In situ construction of rich oxygen vacancy Bi/Bi3TaO7 heterojunction photocatalysts

International Journal of Hydrogen Energy, Journal Year: 2023, Volume and Issue: 48(79), P. 30664 - 30676

Published: May 9, 2023

Language: Английский

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Novel MOF-based vanadium and 2,2 -bipyridine-4,4 -dicarboxylic acid as phenomenal dye adsorbent and antimicrobial agent

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 30, 2025

In this study, a new MOF (metal-organic framework) based on vanadium and 2,2-bipyridine-4,4-dicarboxylic acid (V/BP-MOF) was synthesized. Synthesized V/BP-MOF introduced as strong adsorbent of Congo Red (CR) an effective agent in eliminating microbial species. the investigation CR absorption activity, several factors such concentration V/BP-MOF, pH, time, temperature were investigated. Antimicrobial evaluations carried out Common bacterial strains wastewater values MIC (minimum inhibitory concentration) MBC (Minimum Bactericidal Concentration) reported. The confirmed characterized by EA, EDS, EDS mapping, FT-IR, XRD, TGA, BET, SEM, TEM. checking characteristics size, specific surface area, thermal stability obtained, respectively, 68 nm, 325 m 2 /g, 320°C. highest adsorption CR, at 94%, obtained natural ambient temperature, after 150 min. kinetic studies, correlation coefficient 0.99 observed with pseudo-second-order model, while isotherm 0.97 Freundlich model. biological evaluations, best inhibition against Escherichia coli , 4 μg/mL μg/mL, respectively. As general result, can be potent absorbent dye antimicrobial properties. Therefore, compound synthesized study suitable option for treatment industry, multiple capabilities including removal chemical pollutants pathogenic agents.

Language: Английский

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Sustainable innovative nanofibers containing Cobalt-MOF: a dual-action solution for microbial and chemical wastewater contamination

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: May 8, 2025

Today, wastewater treatment is essential and inevitable due to the water crisis caused by climate change population growth. Although numerous methods synthetic compounds have been successful in practical laboratory applications, developing novel multifunctional remains of interest scientists. For this purpose, a new nanofiber containing Cobalt-MOF (metal-organic framework), polyvinyl alcohol (PVA), pyrrolidone (PVP), which are known environmentally friendly polymers, was synthesized. After characterization structure determination, investigated for its ability adsorb Congo Red dye inhibit microbial species wastewater. This study showed that 91% 400 mg/L red solution absorbed 0.06 g/L synthesized Cobalt-MOF/PVA-PVP Nanofibers at 1 h. Additionally, seven well-known strains (including Aeromonas hydrophila , Legionella pneumophila Mycobacterium tuberculosis Salmonella enterica Pseudomonas aeruginosa Escherichia coli Giardia lamblia ) were inhibited (with MIC 8 μg/mL 64 μg/mL) extent some antibiotics could not affect them. performance newly can be attributed physical, chemical, structural characteristics, such as with biological properties present structure, well high specific surface area. Therefore, researching synthesizing similar using method presented lead their development application processes.

Language: Английский

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Hydrogel Assisted Synthesis of Polymeric Materials Based on Chitosan, Oxidized Pectin, and Tantalum MOF Nanostructures as Potent Antibiotic Agents Against Common Pathogenic Strains Between Humans and Aquatic

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2023, Volume and Issue: 34(2), P. 874 - 884

Published: Sept. 27, 2023

Language: Английский

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Synthesis of Cu/Co-hybrid MOF as a multifunctional porous compound in catalytic applications, synthesis of new nanofibers, and antimicrobial and cytotoxicity agents

Frontiers in Materials, Journal Year: 2023, Volume and Issue: 10

Published: Aug. 31, 2023

Several biological properties of metal–organic frameworks (MOFs) and fiber compounds have been reported, combinations these structures can unique properties. In this study, copper-containing cobalt-containing MOF nanostructures were synthesized by the ultrasonic technique. Then, novel Cu/Co-hybrid using method. Synthesized used as a new efficient recyclable catalyst in synthesis pyrano[2,3- c ]pyrazole derivatives four-component reaction phenylhydrazine, ethyl acetoacetate, malononitrile, aldehyde. following, MOF/PVA (poly vinyl alcohol) electrospinning PVA. The identified confirmed BET, TGA, FTIR, SEM, XRD. studies, antibacterial, antifungal, cytotoxicity activities evaluated. investigating catalytic activity MOF, with higher efficiency less time than previously reported methods. High antibacterial (against gram-negative gram-positive strains) antifungal observed (MIC between 16 256 μg/mL), which some commercial drugs. investigation activity, effectiveness on breast cancer cells was studied. maximum cell proliferation viability for 38% control concentration 200 μg/mL after 48 h. high nanoparticles be attributed to presence nano-sized bioactive metals their specific surface area. significant physical-chemical obtained study related desirable methods, development materials purity, incorporation hybrid into nanostructures.

Language: Английский

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