[BPy][OH] Immobilized Hydrotalcite Clay Catalytic System for 1,2-dihyd-roquinazolines Synthesis DOI
Vivek Srivastava

Current Organocatalysis, Journal Year: 2023, Volume and Issue: 11(1), P. 33 - 43

Published: July 27, 2023

Abstract: We easily synthesized two ionic liquids, [BMIM][OH] and [BPy][OH], with high yield. found that hydrotalcite clay, mediated by these is a highly effective catalyst for synthesizing biologically active 1,2-dihydroquinazoline derivatives. Using simple reaction protocol easy product isolation steps, we successfully 18 different derivatives were able to recycle the catalysts up 8 times. Overall, use of [BPy][OH] provide more efficient environmentally friendly method quinazolines compared traditional methods often require harsh conditions toxic reagents. Background: 1,2-Dihydroquinazolines are an important class heterocyclic compounds diverse biological activities, including anticancer, antifungal, antibacterial properties. They also exhibit other pharmacological activities such as antihypertensive, anti-inflammatory, antiviral effects. The synthesis 1,2-dihydroquinazolines dates early 20th century when they first Pictet Huber in 1911 condensation anthranilic acid aldehydes or ketones presence strong acids. Since then, numerous have been developed their synthesis, cyclization o-aminobenzamides, o-aminoaryl ketones, Lewis acids transition metals. In recent years, development new synthetic selective has great interest chemists, particularly pharmaceutical industry. These include microwave irradiation, ultrasound, liquids green solvents. : area research, continue be improve properties various applications. Methods: yields. Results: our results insights into sustainable 1, 2-dihydroquinazolines. Conclusion: summary, studies demonstrated liquid clay catalytic system could used 2-dihydroquinazolines using aromatic carbonyl compounds, amino benzophenone derivatives, aldehydes. electron-donating substituents phenyl group provided higher yields than electron-withdrawing groups, para position aldehyde had significant effect ortho meta position. Our was recyclable eight runs without loss activity.

Language: Английский

Immobilization of Ni nanoparticles on pyridine-functionalized MWCNTs for indirect synthesis of benzimidazoles and quinazolinones, and their molecular docking studies as effective inhibitors of α-glucosidase DOI
Fatemeh Mirzaeian, Hossein Sabet‐Sarvestani, Hossein Eshghi

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1319, P. 139508 - 139508

Published: Aug. 3, 2024

Language: Английский

Citations

0
Design and synthesis of tetrazole-linked quinazoline derivatives and their bioactivities against Microcystis aeruginosa FACHB905 DOI
Xu Yang, Ding Yuan, Yong Zhang

et al.

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 140, P. 155046 - 155046

Published: April 1, 2024

Language: Английский

Citations

0
Advancements in the Synthesis of Triazolopyrimidines DOI

S. SINGH,

Raman Lakhia,

Sidhant Yadav

et al.

Current Organic Chemistry, Journal Year: 2024, Volume and Issue: 28(20), P. 1567 - 1578

Published: June 26, 2024

: The triazolopyrimidine scaffold indeed holds a prominent place in medicinal chemistry due to its versatile pharmacological properties. Researchers have explored the and derivatives for various therapeutic applications. unique structure of has made it valuable template designing medicinally active molecules. literature is full studies showcasing synthesis biological activities compounds containing ring, either fused or coupled with other heterocycles. aim this review provide comprehensive general summary recent advancements (Year 2021 present).

Language: Английский

Citations

0
Efficient CuOAc/DMAP/DEAD‐Catalyzed Aerobic Oxidative Synthesis of Quinazolines DOI
Yue Ji,

Ze‐Lin Dang,

Menglong Niu

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(39)

Published: Oct. 1, 2024

Abstract Efficient approaches toward the synthesis of quinazolines and dihydroisoquinolines have been developed through copper‐catalyzed aerobic oxidative dehydrogenation N ‐heterocycles. The was achieved azodicarboxylate esters‐mediated amines. Azodicarboxylate esters could be regenerated from corresponding hydrazodicarboxylate esters, which made this catalytic process more efficient reactive.

Language: Английский

Citations

0
Bioisosteric Replacement in the Search for Biologically Active Compounds: Design, Synthesis and Anti-Inflammatory Activity of Novel [1,2,4]triazino[2,3-c]quinazolines DOI Creative Commons

Oleksandr Grytsak,

Kostiantyn Shabelnyk, Hanna Severina

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1437 - 1437

Published: Oct. 28, 2024

Background: Designing novel biologically active compounds with anti-inflammatory properties based on condensed quinazolines is a significant area of interest in modern medicinal chemistry. In the present study, we describe development promising new bioactive molecules through bioisosteric replacement carbon atom sulfur agents, specifically 3-methyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)butanoate. Methods: Design and synthetic studies have led to series previously unknown substituted 2-[((3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)methyl)thio]carboxylic acids their esters. These were synthesized by reacting 6-chloroalkyl-3-R-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones sulfanylalkyl carboxylic functional derivatives. The purity structure obtained confirmed using set physicochemical methods, including elemental analysis, HPLC-MS, 1H NMR spectroscopy. Molecular modeling, predicted toxicity, drug-likeness, pharmacokinetics data used select for evaluation effects acute aseptic inflammation (carrageenan-induced paw edema test) markers inflammatory process. Results: compound 2-((1-(3-methyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)ethyl)thio)acetic acid (compound 2e) was identified as most agent (AA = 53.41%), demonstrating inhibition both generation pro-inflammatory cytokines mediators. Conclusions: Results from docking analysis “structure-affinity” correlations revealed that these are candidates further modification detailed investigation activity

Language: Английский

Citations

0
TFA-mediated nitrogenous heterocyclic assisted aldimine condensation/cyclization for the synthesis of pyrrolo[2′,1′:3,4]quinoxalino[1,2-c]quinazoline derivatives DOI
Wenquan Wang, Quan Liu, Kexin Zhao

et al.

Molecular Catalysis, Journal Year: 2024, Volume and Issue: 572, P. 114733 - 114733

Published: Dec. 9, 2024

Language: Английский

Citations

0
Synthesis and Characterization of Ru(III) Complexes Containing Quinazoline Derivatives and their Biological and Catalytic Activities DOI Open Access
Rita Bhattacharjee,

V. Gayathri

Asian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 35(7), P. 1645 - 1650

Published: Jan. 1, 2023

Ruthenium trichloride trihydrate (RuCl3·3H2O) reacted with quinazoline derivative ligands (L) in 1:1 mole ratio acetone to yield a series of brown/green/greenish black ruthenium(III) complexes the type RuX3L·nH2O where X = Cl, n 0, 1, 2 and 3 L is 6-R-5,6-dihydrobenzoimidazo[1,2- c]quinazoline (R ethyl: L1/n or i-propyl: L2, L3/n i-butyl: L4, L5/phenyl: L6/furyl: L7/thiophenyl: L8/o p-hydroxyphenyl: L9, L10/o p-chlorophenyl: L11, L12/dimethylaminophenyl: L13). All synthesized Ru(III) were characterized by elemental analyses, conductivity measurements, infrared, electronic, ESR mass spectral techniques, TGA, magnetic susceptibility electrochemical studies. A square pyramidal geometry around metal ion was proposed for all complexes. The biological activities ligand its have been studied on microorganisms such as B. subtilis, E. coli yeast cup-plate method. catalytic activity towards oxidation benzyl alcohol, cyclohexanol hydroquinone also carried out acetonitrile tert.-butyl hydroperoxide (t-BuOOH) co-oxidant.

Language: Английский

Citations

0
[BPy][OH] Immobilized Hydrotalcite Clay Catalytic System for 1,2-dihyd-roquinazolines Synthesis DOI
Vivek Srivastava

Current Organocatalysis, Journal Year: 2023, Volume and Issue: 11(1), P. 33 - 43

Published: July 27, 2023

Abstract: We easily synthesized two ionic liquids, [BMIM][OH] and [BPy][OH], with high yield. found that hydrotalcite clay, mediated by these is a highly effective catalyst for synthesizing biologically active 1,2-dihydroquinazoline derivatives. Using simple reaction protocol easy product isolation steps, we successfully 18 different derivatives were able to recycle the catalysts up 8 times. Overall, use of [BPy][OH] provide more efficient environmentally friendly method quinazolines compared traditional methods often require harsh conditions toxic reagents. Background: 1,2-Dihydroquinazolines are an important class heterocyclic compounds diverse biological activities, including anticancer, antifungal, antibacterial properties. They also exhibit other pharmacological activities such as antihypertensive, anti-inflammatory, antiviral effects. The synthesis 1,2-dihydroquinazolines dates early 20th century when they first Pictet Huber in 1911 condensation anthranilic acid aldehydes or ketones presence strong acids. Since then, numerous have been developed their synthesis, cyclization o-aminobenzamides, o-aminoaryl ketones, Lewis acids transition metals. In recent years, development new synthetic selective has great interest chemists, particularly pharmaceutical industry. These include microwave irradiation, ultrasound, liquids green solvents. : area research, continue be improve properties various applications. Methods: yields. Results: our results insights into sustainable 1, 2-dihydroquinazolines. Conclusion: summary, studies demonstrated liquid clay catalytic system could used 2-dihydroquinazolines using aromatic carbonyl compounds, amino benzophenone derivatives, aldehydes. electron-donating substituents phenyl group provided higher yields than electron-withdrawing groups, para position aldehyde had significant effect ortho meta position. Our was recyclable eight runs without loss activity.

Language: Английский

Citations

0