Indian Journal of Pharmaceutical Education and Research,
Journal Year:
2025,
Volume and Issue:
59(1), P. 370 - 376
Published: Jan. 6, 2025
Background
Liver
cancer's
severity
has
prompted
interest
in
herbal
remedies
for
hepatotoxicity
and
the
disease.
Acacia
nilotica
(Vachellia
nilotica),
valued
its
traditional
medicinal
properties,
particularly
aerial
components,
is
being
investigated
hepatoprotective
anti-cancer
effects.
However,
research
on
A.
bark
extracts
their
mechanisms
of
action
limited.
Materials
Methods
The
study
aimed
to
determine
Total
Phenolic
Content
(TPC),
Flavonoid
(TFC),
antioxidant
properties
extract
using
biochemical
assays.
Additionally,
it
examined
protective
effects
normal
Cells
(LO2)
toxicity
against
liver
cancer
cells
(HepG2)
cell
culture
techniques.
Results
showed
significant
(EC50-16.34),
with
a
total
phenolic
content
159.98±9.91
mg
GAE/DW
flavonoid
16.93
QE/g
dry
weight.
It
exhibited
moderate
towards
HepG2
at
concentrations
>100
μg/mL
but
was
non-toxic
LO2
cells.
Moreover,
prevented
oxidative
damage
induced
by
H2O2.
Conclusion
These
findings
highlight
therapeutic
potential
treatment,
warranting
further
clinical
investigation.
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(7), P. 2936 - 2936
Published: March 30, 2024
Herbs
and
agro-food
wastes
are
rich
sources
of
bioactive
compounds
vital
for
organisms
valuable
many
fields
industry.
Therefore,
in
this
study,
green
deep
eutectic
solvents
(DESs)
such
as
choline
chloride/citric
acid
(ChCl:CitA),
glucose/citric
(Gu:CitA),
glucose/urea
(Gu:U),
betaine/citric
(B:CitA),
betaine/urea
(B:U)
at
a
molar
ratio
1:1
ultrasound-assisted
extraction
(UAE)
antioxidants
from
four
herbs
(chamomile—Cha,
lemon
balm—LB,
mint—M,
nettle—N)
two
(buckwheat
husk—BH
chokeberry
pomace—ChoP)
were
proposed.
The
antioxidant
capacity
(AC)
the
obtained
extracts
was
evaluated
utilizing
three
assays:
cupric
reducing
(CUPRAC
=
0.0–429.9
μmol
Trolox
(TE)/g);
2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic
acid)
(ABTS
0.0–146.5
TE/g);
2,2-diphenyl-1-picrylhydrazyl
(DPPH
11.9–170.3
TE/g).
LB
revealed
highest
CUPRAC
(59.3–429.9
TE/g),
ABTS
(30.7–144.3
DPPH
(32.6–170.3
TE/g)
values.
Due
to
lowest
potential
prepared
using
ChCl:CitA
(AC
30.7–59.3
AC
demonstrated
by
based
on
B:U
144.3–429.9
UAE
conditions
new
DES
consisting
ChCl
U
optimized
Box–Behnken
design
(BBD).
Effects
independent
variables,
ratios
(mol/mol),
water
content
(%),
sonication
time
(t)
studied
response
surface
methodology
(RSM).
results
principal
component
analysis
(PCA)
hierarchical
cluster
(HCA)
that
different
DESs
had
great
differences
residues.
Microbiological Research,
Journal Year:
2024,
Volume and Issue:
287, P. 127857 - 127857
Published: July 26, 2024
The
microbiota
in
the
female
genital
tract
is
an
intricate
assembly
of
diverse
aerobic,
anaerobic,
and
microaerophilic
microorganisms,
which
share
space
within
reproductive
engage
complex
interactions.
Microbiome
dysbiosis
may
disrupt
symbiotic
relationship
between
host
microorganisms
play
a
pivotal
role
pathogenesis
various
diseases,
including
its
involvement
establishment
human
papillomavirus
(HPV)-associated
cervical
cancer
(CC).
Interventions
to
restore
homeostasis
(e.g.,
probiotics)
bacterial-vector
HPV
therapeutic
vaccines
have
been
reported
be
potentially
effective
clearing
infection
ameliorating
cytological
abnormalities.
In
this
review,
we
place
emphasis
on
elucidating
alterations
cervical-vaginal
as
well
intratumoral
context
high-risk
(HR-HPV)
subsequent
progression
intraepithelial
neoplasia/CC.
Furthermore,
explore
mechanisms
by
these
microbial
communities
exert
potential
pathogenic
or
protective
effects,
modulating
inflammation
immune
responses,
affecting
HR-HPV
oncogene
expression
oncoprotein
production,
regulating
oxidative
stress
deoxyribonucleic
acid
(DNA)
damage,
inducing
metabolic
rewiring.
Lastly,
summarize
latest
evidence
trials
regarding
efficacy
probiotics,
prebiotics
probiotic-vector
vaccines.
This
review
aims
foster
deeper
understanding
infection-related
cervix
development,
further
provide
theoretical
basis
for
development
preventive
strategies
based
modulation.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1462 - 1462
Published: Nov. 28, 2024
Upregulation
of
reactive
oxygen
species
(ROS)
levels
is
a
principal
feature
observed
in
the
brains
neurodegenerative
diseases
such
as
Parkinson’s
disease
(PD)
and
Alzheimer’s
(AD).
In
these
diseases,
oxidative
stress
can
disrupt
blood–brain
barrier
(BBB).
This
disruption
allows
neurotoxic
plasma
components,
blood
cells,
pathogens
to
enter
brain,
leading
increased
ROS
production,
mitochondrial
dysfunction,
inflammation.
Collectively,
factors
result
protein
modification,
lipid
peroxidation,
DNA
damage,
and,
ultimately,
neural
cell
damage.
this
review
article,
we
present
mechanisms
by
which
damage
leads
BBB
breakdown
brain
diseases.
Additionally,
summarize
potential
therapeutic
approaches
aimed
at
reducing
that
contributes
Indian Journal of Pharmaceutical Education and Research,
Journal Year:
2025,
Volume and Issue:
59(1), P. 370 - 376
Published: Jan. 6, 2025
Background
Liver
cancer's
severity
has
prompted
interest
in
herbal
remedies
for
hepatotoxicity
and
the
disease.
Acacia
nilotica
(Vachellia
nilotica),
valued
its
traditional
medicinal
properties,
particularly
aerial
components,
is
being
investigated
hepatoprotective
anti-cancer
effects.
However,
research
on
A.
bark
extracts
their
mechanisms
of
action
limited.
Materials
Methods
The
study
aimed
to
determine
Total
Phenolic
Content
(TPC),
Flavonoid
(TFC),
antioxidant
properties
extract
using
biochemical
assays.
Additionally,
it
examined
protective
effects
normal
Cells
(LO2)
toxicity
against
liver
cancer
cells
(HepG2)
cell
culture
techniques.
Results
showed
significant
(EC50-16.34),
with
a
total
phenolic
content
159.98±9.91
mg
GAE/DW
flavonoid
16.93
QE/g
dry
weight.
It
exhibited
moderate
towards
HepG2
at
concentrations
>100
μg/mL
but
was
non-toxic
LO2
cells.
Moreover,
prevented
oxidative
damage
induced
by
H2O2.
Conclusion
These
findings
highlight
therapeutic
potential
treatment,
warranting
further
clinical
investigation.
