Application of Nanotechnology in Cancer Therapy: Potential and Limitations DOI
Susanta Mondal, Debapriya Basu, Buddhadev Maiti

et al.

Published: July 1, 2024

Abstract Nanotechnology is an emerging platform for increasing the selectivity and potency of different treatment modalities progressive cancer therapy. Architectures nanoscale are successively explored delivery water-insoluble drug molecules as well malignant cell targeting, avoiding nonspecific toxicity. can also help in synergistic application therapeutics. Despite numerous advantages, clinical nanoformulations limited due to poor biodistribution, failure enhanced permeability retention-dependent change biophysical properties physiological environment. In this review, we summarized promising nanotechnology combination with relevant challenges, corresponding literature current status.

Language: Английский

Metal–organic frameworks for biological applications DOI
Isabel Abánades Lázaro, Xu Chen,

Mengli Ding

et al.

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: June 27, 2024

Language: Английский

Citations

48
Nanoparticle innovations in targeted cancer therapy: advancements in antibody–drug conjugates DOI Creative Commons
Magdi T. Abdelhamid, Al-Hassan Soliman Wadan,

Hosam A. Saad

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 18, 2025

Language: Английский

Citations

4
Cutting-Edge Therapies for Lung Cancer DOI Creative Commons

Anita Silas La’ah,

Shih‐Hwa Chiou

Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 436 - 436

Published: March 1, 2024

Lung cancer remains a formidable global health challenge that necessitates inventive strategies to improve its therapeutic outcomes. The conventional treatments, including surgery, chemotherapy, and radiation, have demonstrated limitations in achieving sustained responses. Therefore, exploring novel approaches encompasses range of interventions show promise enhancing the outcomes for patients with advanced or refractory cases lung cancer. These groundbreaking can potentially overcome resistance offer personalized solutions. Despite rapid evolution emerging therapies, persistent challenges such as resistance, toxicity, patient selection underscore need continued development. Consequently, landscape therapy is transforming introduction precision medicine, immunotherapy, innovative modalities. Additionally, multifaceted approach involving combination therapies integrating targeted agents, immunotherapies, traditional cytotoxic treatments addresses heterogeneity while minimizing adverse effects. This review provides brief overview latest are reshaping treatment. As these progress through clinical trials integrated into standard care, potential more effective, targeted, comes focus, instilling renewed hope facing challenging diagnoses.

Language: Английский

Citations

10
Cutting-Edge Therapies for Lung Cancer DOI Open Access

Anita Silas La’ah,

Shih-Hwa Chiou

Published: Jan. 24, 2024

Lung cancer remains a formidable global health challenge that necessitates inventive strategies to improve therapeutic outcomes. Conventional treatments, including surgery, chemotherapy, and radiation, have demonstrated limitations in achieving sustained responses. Therefore, the explora-tion of novel approaches encompasses range interventions show promise enhancing outcomes for patients with lung cancer, particularly those facing advanced or refractory cases. These groundbreaking hold potential overcome resistance offer personalized solutions. Despite rapid evolution emerging therapies, persistent challenges such as resistance, toxicity, patient selection underscore need continued development. Consequently, landscape therapy is transforming in-troduction precision medicine, immunotherapy, innovative modalities. Addi-tionally, multifaceted approach involving combination therapies through integration tar-geted agents, immunotherapies, traditional cytotoxic treatments addresses heterogeneity while minimizing adverse effects. This review provides brief overview latest are reshaping treatment. As these progress clinical trials integrate into standard care, more effective, targeted, comes focus, instilling renewed hope challenging diagnoses.

Language: Английский

Citations

5
Quantification of Azides on the Surface of Nanoparticles: Toward Precise Bioconjugation DOI Creative Commons
Elizaveta A. Maksimova, David E. Salazar Marcano, Jonathan De Roo

et al.

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

The precise design of bioconjugated nanoparticles is crucial for effective cell targeting and cellular uptake. Therefore, an accurate approach to creating quantifying the organic ligand shell with a specific number conjugated ligands essential. Click chemistry has emerged as robust method bioconjugation, azide–alkyne cycloaddition most prevalent method. Although are typically functionalized azides, their quantification rarely been reported. Here, two spectroscopic methods surface azide catechol‐stabilized hafnium oxide model system presented. first exploits intrinsic ability catechol quench fluorescence fluorophores, whereas second represents general strategy based on monitoring alkyne absorbance during click reaction. latter independent both inorganic core shell, allowing it be generally used. broader applicability capped polyphosphonate also demonstrated.

Language: Английский

Citations

0
Hafnium-Doped Prussian Blue Nanoparticles with Homologous Tumor Targeting and Magnetic Resonance Imaging Ability for Enhanced Tumor Radiotherapy via Photothermal Therapy and Hypoxia Relief DOI
Ye Kuang, Yufang Chen, Xinying Liu

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Radiotherapy (RT) continues to encounter significant obstacles such as formidable resistance, potential harm adjacent healthy cells, and restricted effectiveness against tumors, resulting in a notable recurrence rate. Therefore, combining imaging, other treatments, suitable enzyme activity one nanoplatform can enhance the RT effect reduce damage normal tissue. In this study, integrating hafnium Prussian blue (PB) nanoparticles (PB NPs) provided innovative hafnium-doped PB (HPB) NPs multifunctional radiosensitizers. The HPB were enveloped by cancer cell membrane, membrane-camouflaged (CMHPB) that specifically target homologous tumors. Moreover, owing inherent ability of photothermal therapy (PTT), magnetic resonance imaging (MRI), catalase (CAT)-like NPs, CMHPB effectively overcome tumor hypoxia realize MRI-guided combined PTT. prepared possessed uniform cubic morphology with monodisperse size approximately 80 nm T1 MRI capability (r1 = 0.9309 mM-1 S-1). showed reliable PTT efficiency CAT-like vitro vivo. Guided MRI, be precisely delivered region for targeted destruction significantly inhibiting growth. used PTT, which address key challenges provide viable strategy enhancing treatment.

Language: Английский

Citations

0
Development of Er-doped CaHfO3 Single-crystal-scintillators Emitting Near-infrared Photons DOI
Yusuke Endo, Kensei Ichiba, Daisuke Nakauchi

et al.

Solid State Sciences, Journal Year: 2024, Volume and Issue: 160, P. 107783 - 107783

Published: Dec. 7, 2024

Language: Английский

Citations

2
A Zeolitic Imidazolate Framework-Based Antimicrobial Peptide Delivery System with Enhanced Anticancer Activity and Low Systemic Toxicity DOI Creative Commons
Jingwen Jiang,

Kaderya Kaysar,

Yanzhu Pan

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1591 - 1591

Published: Dec. 13, 2024

Background: The clinical efficacies of anticancer drugs are limited by non-selective toxic effects on healthy tissues and low bioavailability in tumor tissue. Therefore, the development vehicles that can selectively deliver release at site is critical for further improvements patient survival. Methods: We prepared a CEC nano-drug delivery system, CEC@ZIF-8, with zeolite imidazole framework-8 (ZIF-8) as carrier, which achieve response folate receptor (FR). characterized this system terms morphology, particle size, zeta potential, infrared (IR), x-ray diffraction (XRD), transcriptome analysis, examined vitro cytotoxicity cellular uptake properties CEC@ZIF-8 using cervical cancer cells. Lastly, we established TC-1 tumor-bearing mouse model evaluated its vivo anti-cervical activity. Results: nano-delivery had favorable biocompatibility, heat stability, pH responsiveness, loading efficiency 12%, hydrated size 174 ± 5.8 nm, potential 20.57 mV, slow massive drug an acidic environment (pH 5.5), whereas was 6% neutral 7.4). At same time, confocal imaging cell viability assays demonstrated greater intracellular accumulation more potent against cells compared to free CEC. mechanism analyzed series analyses, revealed NPs differentially regulate expression levels 1057 genes cells, indicated enriched pathways were mainly cycle apoptosis-related via enrichment analysis differential genes. Flow cytometry showed inhibited growth HeLa arresting G0/G1 phase. also induced apoptosis rates than CEC, while unloaded ZIF-8 little inherent pro-apoptotic Furthermore, reactive oxygen species (ROS) upregulated ROS inhibitors caspase reversed NPs-induced apoptosis. Finally, reduced rate xenograft tumors mice without systemic toxicity observed cisplatin treatment. Conclusions: significantly enhanced effect both vitro, providing promising applications management. work demonstrates CEC-loaded nanoparticles selective destruction tissues.

Language: Английский

Citations

1
Stimuli-responsive nanocarriers in clinical translation DOI
Muhammad Raza Shah, Tooba Jabri, Maria Khalid

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 321 - 360

Published: Oct. 4, 2024

Citations

0
Thiolaryl substituted β-lactams as important capping agents for hafnia nanoparticles DOI

Aarti Thakur,

Mehar Singh,

Preeti Garg

et al.

Journal of Sulfur Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Dec. 6, 2024

A new study on the synthesis of β-lactams functionalized hafnia nanoparticles is done. The reported work describes utility hydrothermal method to prepare coated with β-lactams. provides spherical NPs dimensions 30–50 nm and are slightly anionic. conjugate has been found be biologically active well characterized by techniques like FTIR, XRD, FESEM, TEM, EDX methods. methodology gives a whose not attempted so far in literature.

Language: Английский

Citations

0