Dietary Phenolic Compounds—Wellbeing and Perspective Applications

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4769 - 4769

Published: April 27, 2024

Contemporary living is continuously leading to poor everyday choices resulting in the manifestation of various diseases. The benefits plant-based nutrition are undeniable and research on topic rising. Modern man now aware possibilities that plant can provide seeking ways benefit from it. Dietary phenolic compounds among easily accessible beneficial substances exhibit antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, antifungal, antiparasitic, analgesic, anti-diabetic, anti-atherogenic, antiproliferative, as well cardio-and neuroprotective activities. Several industries exploring incorporate biologically active their produce. This review concentrated presenting current information about dietary contribution maintaining good health. Additionally, this content will demonstrate importance prosperity natural for fields, i.e., food industry, cosmetology, biotechnology, others.

Language: Английский

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Natural Guardians: Natural Compounds as Radioprotectors in Cancer Therapy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6937 - 6937

Published: June 25, 2024

Cancer remains a significant global health challenge, with millions of deaths attributed to it annually. Radiotherapy, cornerstone in cancer treatment, aims destroy cells while minimizing harm healthy tissues. However, the harmful effects irradiation on normal present formidable obstacle. To mitigate these effects, researchers have explored using radioprotectors and mitigators, including natural compounds derived from secondary plant metabolites. This review outlines diverse classes compounds, elucidating their roles as protectants cells. Furthermore, highlights potential radioprotective agents capable enhancing body's resilience radiation therapy. By integrating into treatment regimens, clinicians may improve therapeutic outcomes adverse Ongoing research this area holds promise for developing complementary strategies optimize radiotherapy efficacy enhance patient quality life.

Language: Английский

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Linearly ring-fused coumarins: A review of their cancer-fighting attributes

Results in Chemistry, Journal Year: 2024, Volume and Issue: 8, P. 101611 - 101611

Published: June 1, 2024

Despite the up-to-date advancements in its treatment, cancer is still being harvested lives of millions people annually; this health threat necessitates exploring more potent agents that can effectively fight it. The class heterocycles known as coumarin, and natural synthetic derivatives are thought to be biomedically valuable. Coumarins have low side effects, outstanding selectivity, a straightforward design for maximum efficiency, various pharmacological actions. For these characteristics, coumarins continuously isolated from sources synthesized laboratories, alongside with examining them possible bioactivities. In addition garnering significant attention, coumarin has emerged valuable scaffold potentially important precursor development innovative anticancer medicines. Researchers working create new cancer-fighting coumarins, well investigating old ones. Integration two or cyclic moieties into single molecular framework might enhance existing effects perhaps provide entirely Numerous studies shown synergistic additive impact when fused where fusion may occur at coumarin-benzene coumarin-lactone. current paper explores detail how linearly ring-fused combat cancer. derivative number 42 was determined best among were reviewed. Compared 5-flourouracil, IC50 values against six cell lines promising. These 25.08, 13.42, 41.45, 28.43, 31.15, 13.08 μM SK-OV-3, HeLa, KYSE-30, AMN3, SKG, MCF-7, respectively. attribute obvious compared those reference, which following same order lines: 22.43, 13.37, 30.72, 24.89, 22.12, 12.42 μM. researchers conducted searches across multiple data repositories, such Scopus, Google Scholar, Web Science, PubMed. After conducting thorough analysis, authors found included 59 pertinent publications published by end 2023. reviewed help medicinal chemists manufacture functionally active leads using scaffolds been mentioned. knowledge derived offer substantial medical benefits short term powerful drugs could boost chemotherapeutics.

Language: Английский

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Naturally Inspired Coumarin Derivatives in Alzheimer’s Disease Drug Discovery: Latest Advances and Current Challenges

Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3514 - 3514

Published: July 26, 2024

The main feature of neurodegenerative diseases, including Alzheimer's disease, is the network complex and not fully recognized neuronal pathways targets involved in their onset progression. therapeutic treatment, at present mainly symptomatic, could benefit from a polypharmacological approach based on development single molecular entity designed to simultaneously modulate different validated biological targets. This strategy principally hybridization, obtained by linking or merging chemical moieties acting with synergistic and/or complementary mechanisms. coumarin core, widely found nature, endowed broad spectrum pharmacological activities, large synthetic accessibility favourable pharmacokinetic properties, appears as valuable, privileged scaffold be properly modified order obtain compounds able engage selected scientific literature has long been interested multifaceted profiles derivatives, this review, survey most important results last four years, both natural coumarin-based compounds, regarding anti-Alzheimer's reported.

Language: Английский

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Derivatization and Anti-Butyrylcholinesterase Activity of Coumarinolignans: Experimental and Computational Approaches

Chemistry Africa, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Language: Английский

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Zebrafish as a Suitable Model for Utilizing the Bioactivity of Coumarins and Coumarin-Based Compounds

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1444 - 1444

Published: Feb. 8, 2025

The aim of this review is to summarize the current knowledge on use coumarin-derived compounds in zebrafish (Danio rerio) model. Coumarins, a class naturally occurring with diverse biological activities, including such as coumarin, angelicin, and warfarin, have attracted considerable attention study potential therapeutic agents for cancer, central nervous system disorders, infectious diseases. capabilities coumarins active led synthesizing various derivatives their own properties. While variety certainly promising, it also cumbersome due large amount research needed find most optimal compounds. model offers unique advantages studies, high genetic physiological homology mammals, optical transparency embryos, rapid developmental processes, facilitating assessment compound toxicity underlying mechanisms action. This provides an in-depth analysis chemical properties coumarins, activity, results previous studies evaluating efficacy these assays. allows holistic coumarin derivatives, offering valuable insights advancing drug discovery development.

Language: Английский

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Mechanistic Insights into the Stimulatory Effect of Melanogenesis of 4-Methylcoumarin Derivatives in B16F10 Melanoma Cells

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12421 - 12421

Published: Nov. 19, 2024

Vitiligo is a skin condition characterized by the loss of pigment, resulting in white patches on various parts body. It occurs when melanocytes, cells that are responsible for producing destroyed or stop functioning. This study aimed to investigate melanogenic potential 4-methylcoumarin (4MC) derivatives, including 6-methoxy-4-methylcoumarin (6M-4MC), 7-methoxy-4-methylcoumarin (7M-4MC), 7-amino-4-methylcoumarin (7A-4MC), 6,7-dihydroxy-4-methylcoumarin (6,7DH-4MC), 7,8-dihydroxy-4-methylcoumarin (7,8DH-4MC), and 6,7-dimethoxy-4-methylcoumarin (6,7DM-4MC), B16F10 melanoma cells. Our findings revealed that, while 4MC, 7A-4MC, 6,7DH-4MC, 7,8DH-4MC did not exhibit any effect melanin production, significant stimulation melanogenesis was observed with 6M-4MC, 7M-4MC, 6,7DM-4MC, 6M-4MC demonstrating most pronounced effect. significantly stimulated production tyrosinase activity concentration-dependent manner A Western blot analysis increased expression levels microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein-1 (TRP-1), protein-2 (TRP-2). Further mechanistic studies showed inhibited extracellular signal-regulated kinase (ERK) protein B (AKT), which led upregulation MITF TRP proteins subsequent activation synthesis. Additionally, activated GSK3β phosphorylation, reduced β-catenin via GSK3β/β-catenin pathway. Moreover, primary irritation test conducted upper backs 32 healthy female volunteers assess sensitization from applied topically at concentrations 50 µM 100 µM. The results no adverse effects skin. Collectively, these suggest may be promising pigmentation stimulator use cosmetics medical treatment hypopigmentation disorders, particularly conditions such as vitiligo.

Language: Английский

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Coumarin-Based ACQ-AIE Conversion Photosensitizer for Mitochondrial Imaging and Synergistic Cancer Therapy

The Journal of Physical Chemistry Letters, Journal Year: 2024, Volume and Issue: 15(43), P. 10866 - 10872

Published: Oct. 23, 2024

Most of the traditional fluorescent molecules have advantages high fluorescence quantum yield, good stability, and excellent structural adjustability, but they exhibit characteristics quenching caused by aggregation, which restricts their application in aqueous solutions or solids. The luminescence properties photosensitive potential aggregation-induced emission (AIE) materials a condensed state made them widely concerned scientific research field, so it is very challenging to regulate transformation aggregation-caused (ACQ) fluorophores into AIE fluorophores. In this study, coumarin fluorophore was used as matrix. After conjugating triphenylamine group, triphenylphosphine cation linked through alkyl chain obtain molecular probe NCTPP with characteristic, water solubility, mitochondrial green light imaging, chemotherapy photodynamic therapy capabilities. As far we know, first time that photosensitivity imparted ACQ-AIE conversion method.

Language: Английский

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Structural characterization, theoretical, and antibacterial activity study of halogen-η3-allylpalladium(II) complexes incorporating 2-, 3- and 4-pyridyl-methylen-4-methylumbelliferone esters

Polyhedron, Journal Year: 2025, Volume and Issue: unknown, P. 117414 - 117414

Published: Jan. 1, 2025

Language: Английский

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Characterization of chemical compounds of fractions from four different bee pollens with chemometric classification

European Food Research and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract Bee pollen continues to increase its popularity as a ‘complete food’ among natural resources with high health value and therapeutic chemical compounds. This study focused on HPLC-DAD (high-performance liquid chromatography-diode array detection) based the identification of compounds Cistus creticus , Helianthus annuus Papaver somniferum Salix sp. bee pollens. Also, water extracts fractions (hexane, dichloromethane, ethyl acetate, butanol, water) obtained from methanol all pollens were investigated for A total 29 screened kaempferol was detected in studied samples at concentration 0.4 331.6 µg/g. Luteolin (68.7–694.8 µg/g), trans -aconitic acid (12.2–479.1 myricetin (160.4–1534.2 quercetin (162.1–608.1 rosmarinic (273.8–435.6 rutin (3.6–202.8 -cinnamic (5.1–1854.6 µg/g) found most abundant Additionally, nonpolar polar chemometrically clustered similarities differences via principal component analysis (PCA) hierarchical cluster (HCA). In fractions, C. H. P. acetate (CEA, HEA, PEA, SEA) separated other while butanol (CB, HB, PB, SB) fractions. provides additional data characterization valuable constitutes beginning chemometric classification

Language: Английский

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