Therapeutic potential of silver nanoparticles from Helianthemum lippii extract for mitigating cadmium-induced hepatotoxicity: liver function parameters, oxidative stress, and histopathology in wistar rats

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: June 27, 2024

Introduction: This study explores the therapeutic potential of silver nanoparticles (Ag NPs) synthesized using a Helianthemum lippii extract in mitigating cadmium-induced hepatotoxicity Wistar rats. Given increasing environmental and health concerns associated with cadmium exposure, novel eco-friendly strategies are essential. Methods: Ag NPs were characterized X-ray diffraction, UV-Vis spectrometry, energy-dispersive spectroscopy scanning electron microscopy, confirming their formation cubic crystal structure particle sizes ranging from 4.81 to 12.84 nm. A sub-acute toxicity (2 mg/kg 10 mg/kg) was conducted, showing no significant difference compared untreated control rats ( n = 3 animals/group). Subsequently, adult 5/group) divided into group three experimental groups: alone, exposure 50 CdCl 2 drinking water for 35 days, followed by 0.1 mg/kg/day intraperitoneally 15 days. Results: In -exposed group, there decrease body weight increases alanine aspartate transaminase levels p < 0.05 vs. control), indicating hepatotoxicity. Additionally, antioxidant defenses decreased, malondialdehyde elevated. Liver histology revealed portal fibrosis, inflammation, necrosis, sinusoid hepatic vein dilation, cytoplasmic vacuolations. Treatment post-CdCl mitigated several adverse effects on liver function architecture improved weight. Discussion: demonstrates efficacy via green method reducing damage. These findings support applications highlight importance sustainable nanoparticle synthesis methods. By addressing both efficacy, this research aligns growing emphasis environmentally conscious practices scientific healthcare.

Language: Английский

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Oxidative stress-induced cytotoxicity of HCC2998 colon carcinoma cells by ZnO nanoparticles synthesized from Calophyllum teysmannii

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 4, 2024

The field of green synthesis, namely using plant extracts for the production metal nanoparticles, is rapidly gaining traction. Therefore, this study investigated process producing zinc oxide nanoparticles (ZnO NPs) a water-based extract derived from stem bark Calophyllum teysmannii. Notably, first documented utilization particular source. presence distinct Ultraviolet-Visible (UV-Vis) absorption peak at 372 nm provided evidence creation ZnO nanoparticles. X-ray Diffractometer (XRD) and Field Emission Scanning Electron Microscopy (FESEM) investigations indicated that exhibited sizes ranging 31.5 to 59.9 had spherical morphologies. Energy Dispersive (EDX) analysis verified elemental composition whereas Fourier Transform Infrared (FTIR) spectra showed clear peaks, demonstrating their production. FTIR examination C. teysmannii revealed peaks around 3370 cm− 1, indicating phenolic compounds. These chemicals are likely responsible reduction stabilization NPs. high-resolution Photoelectron Spectroscopy (XPS) clearly separate corresponding Zn 2p O 1s, providing confirmation chemical states bonding contexts. Raman 425 cm⁻¹, confirming wurtzite structure. harmful effects on HCC2998 (a kind human colon cancer) Vero type monkey kidney epithelial) cells were evaluated 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT), dichlorodihydrofluorescein diacetate (DCFH-DA), boron-Dipyrromethene (BODIPY) assays. cancer underwent cell death due oxidative stress in dose-dependent manner, as confirmed by microscopic flow cytometry investigations.

Language: Английский

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Evaluation of the Photocatalytic and Antimicrobial Properties of Cu-Doped ZnO Nanoparticles Synthesized by Phytochemical Methods

Journal of nano research, Journal Year: 2025, Volume and Issue: 87, P. 75 - 94

Published: March 26, 2025

In this study, zinc oxide (ZnO) and copper-doped nanoparticles (Cu-ZnO NPs) were synthesized using a green method that employed Rosmarinus officinalis leaf extract as reducing agent. Copper was incorporated dopant at concentrations of 3% 5%. Zinc acetate dihydrate copper served the precursors dopants, respectively. The samples characterized utilizing range techniques, including XRD, SEM, EDX, Raman spectroscopy, UV-visible PL spectroscopy. XRD spectroscopy analyses validated effective incorporation Cu²⁺ ions into ZnO wurtzite structure. SEM analysis indicated displayed spherical morphology, while EDX confirmed presence (Zn), (Cu), oxygen (O), thereby validating sample's purity. spectra revealed reduction in optical band gap with increasing Cu concentration. Photoluminescence peaks observed 383 nm 565 ascribed to electron transitions from deep donor levels, particularly Zn interstitials vacancies. 5% Cu-doped NPs demonstrated highest photocatalytic activity, achieving 90% degradation Rhodamine B (RhB) dye under UV irradiation 135 minutes. They also exhibited significant antibacterial against Gram-positive bacteria ( Staphylococcus aureus ) compared Gram-negative Escherichia coli ).

Language: Английский

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Synthesis of novel MgO-ZnO nanocomposite using Pluchea indica leaf extract and study of their biological activities

Bioresources and Bioprocessing, Journal Year: 2025, Volume and Issue: 12(1)

Published: April 12, 2025

The biosynthesis of bimetallic nanoparticles using plant extracts has garnered significant attention due to their eco-friendly and cost-effective nature. This study aimed biosynthesize magnesium oxide-zinc oxide nanocomposite (MgO-ZnO nanocomposite) Pluchea indica leaf extract for the first time, with a focus on characterizing its physicochemical properties evaluating biological activities. biosynthesized MgO-ZnO was fully characterized, revealing an absorbance peak at 300 nm UV-vis spectroscopy. Transmission electron microscopy (TEM) confirmed particle stability within size range 5-35 nm. Cytotoxicity analysis Wi 38 normal cell line demonstrated IC50 value 179.13 µg/mL, indicating good biosafety. exhibited potent anticancer activity, values 73.61 µg/mL 31.25 against Hep-G2 MCF-7 cancer lines, respectively. Antibacterial assays revealed activity Klebsiella pneumoniae, Escherichia coli, Bacillus cereus, Staphylococcus aureus, Candida albicans, minimum inhibitory concentrations (MICs) ranging from 250 µg/mL. Furthermore, displayed antioxidant 175 as determined by DPPH assay. In conclusion, successful synthesis P. demonstrates potential safe effective agent concentration-dependent antioxidants, antibacterial, applications. highlights versatility plant-mediated in developing functional nanomaterials biomedical use.

Language: Английский

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Solar light driven boost photocatalytic activity and tailoring bandgap of Zn-Mn3O4/TiO2 hetero-structures for degradation of organic dyes

Journal of Alloys and Compounds, Journal Year: 2025, Volume and Issue: unknown, P. 180436 - 180436

Published: April 1, 2025

Language: Английский

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Ephedra herb as a sustainable source: Insights into its role in metal nanoparticle synthesis—A review

Environmental Progress & Sustainable Energy, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract There are various physical and chemical techniques for the synthesis of nanoparticles. However, green nanoparticles, particularly biosynthesis metal nanoparticles using plants, has garnered significant interest from researchers worldwide. In addition to being an environmentally safe technique, offers numerous biological applications, including antifungal, antiviral, antibacterial, wound healing, antioxidant, antitumor properties. Ephedra (ma‐huang) is a valuable resource phytochemical components that have pharmaceutical effects, such as phenolic compounds, reducing sugars, flavonoids, alkaloids, tannins, saponins. These which possess antimicrobial antioxidant attracted attention stabilizing agents facilitate metallic oxide Various silver, gold, copper, selenium, arsenic, zinc, been synthesized extracts, demonstrating This study aims investigate utilizing different species plant explore their applications.

Language: Английский

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Green synthesis of CaO nanoparticles from chicken eggshells: antibacterial, antifungal, and heavy metal (Pb2⁺, Cr2⁺, Cd2⁺ and Hg2⁺) adsorption properties

Frontiers in Environmental Science, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 30, 2024

Background Chicken eggshells, a common poultry byproduct, are rich in calcium and provide sustainable source for producing oxide nanoparticles (CaO NPs). Their use eco-friendly synthesis aligns with the growing emphasis on materials environmental biomedical applications. Objectives: This study develops an method synthesizing CaO NPs from chicken characterizes their physicochemical properties, evaluates antibacterial antifungal activities. It also tests effectiveness removing heavy metal ions (Pb 2 ⁺, Cr Cd Hg ⁺) aqueous solutions. Methods were synthesized by calcining eggshells at 700°C 7 h. Comprehensive characterization included analysis of crystalline structure, morphology, optical bandgap energy, chemical composition, thermal stability. Antibacterial activities tested using well-agar diffusion method. Batch adsorption experiments evaluated ion removal under varying conditions pH, temperature, stirring time, adsorbent concentration Results The produced spherical, single-crystal diameters ranging 5 to 30 nm size approximately 20 nm. had energy about 4.7 eV. Significant activity was observed against Staphylococcus aureus , Klebsiella pneumoniae Escherichia coli increasing inhibition zones correlating nanoparticle concentration. effectively inhibited Candida albicans . For efficient removal, optimal found be min pH 6 40 mg 25°C, achieving recovery rates 98% Pb 97% ⁺. near-complete extending process 70 45°C achieved highest rates: 99% though this approach involves higher cost. Conclusion derived effective agents adsorbents removal. These findings highlight potential applications fields.

Language: Английский

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Exploring the Antioxidant, Anti-Inflammatory, and Antibacterial Properties of Green-Synthesized ZnO Nanoparticles Using Juniperusphoenicea L.

Chemistry Africa, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Language: Английский

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Microwave-assisted green synthesis of zinc oxide nanoparticles using pistia stratiotes for anticancer and antibacterial applications

Materials Research Express, Journal Year: 2024, Volume and Issue: 11(8), P. 085004 - 085004

Published: Aug. 1, 2024

Abstract Green synthesis techniques have recently become more popular due to the expanding interest in nanotechnology and need for ecologically friendly processes. This work examines environment production of Zinc Oxide Nanoparticles (ZnO NPs) by a microwave-assisted technique, utilizing Pistia Stratiotes leaf extract as reducing agent. The optical structural properties produced ZnO NPs were analyzed using UV–vis spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), Scanning (SEM), x-ray Diffraction (XRD). findings indicated that displayed shapes consisting spherical, flower sheet, with an average size 35 nm which was verified SEM TEM. XRD examination confirmed presence hexagonal wurtzite crystalline structure, while FTIR analysis identified distinct peak at 578 cm −1 , indicates stretching mode Zn-O bonds. antibacterial antifungal substance evaluated against Staphylococcus Aureus, Escherichia Coli Candida Albicans . results demonstrated notable effectiveness, inhibition zones measuring 16–20.4 mm, 17–21.3 13–17.2 mm correspondingly. In addition, exhibited specific anti-cancer effects on SK-MEL-28 melanoma cell lines, IC 50 value 51.05 μg ml suggesting potential uses therapy. study demonstrates feasibility green create favorable characteristics biomedical purposes, particular focus sustainable manufacturing nanomaterials. indicate these show great application antibacterial, antifungal, anticancer therapies, leading developments field medical nanotechnology.

Language: Английский

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