Nutraceutical approaches to non-alcoholic fatty liver disease (NAFLD): A position paper from the International Lipid Expert Panel (ILEP)

Pharmacological Research, Journal Year: 2023, Volume and Issue: 189, P. 106679 - 106679

Published: Feb. 8, 2023

Non-Alcoholic Fatty Liver Disease (NAFLD) is a common condition affecting around 10–25% of the general adult population, 15% children, and even > 50% individuals who have type 2 diabetes mellitus. It major cause liver-related morbidity, cardiovascular (CV) mortality death. In addition to being initial step irreversible alterations liver parenchyma causing cirrhosis, about 1/6 those develop NASH are at risk also developing CV disease (CVD). More recently acronym MAFLD (Metabolic Associated Disease) has been preferred by many European US specialists, providing clearer message on metabolic etiology disease. The suggestions for management NAFLD like recommended guidelines CVD prevention. this context, approach prescribe physical activity dietary changes effect weight loss. Lifestyle change in patient supplemented some use nutraceuticals, but evidence based these remains uncertain. aim Position Paper was summarize clinical relating nutraceuticals NAFLD-related parameters. Our reading data that whilst studied relation NAFLD, none sufficient recommend their routine use; robust trials required appropriately address efficacy safety.

Language: Английский

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The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 1, 2024

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, emerging as a significant health issue on global scale. Berberine exhibits potential for treating NAFLD, but clinical evidence remains inconclusive. This meta-analysis was conducted to assess the efficacy and safety of berberine NAFLD. Methods study registered with PROSPERO (No. CRD42023462338). Identification randomized controlled trials (RCTs) involved searching 6 databases covering period from their initiation 9 September 2023. The primary outcomes comprised function markers such glutamyl transpeptidase (GGT), alanine transaminase (ALT), aspartate (AST), lipid indices including total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C) high-density (HDL-C), homeostasis model assessment insulin resistance (HOMA-IR) body mass index (BMI). Review Manager 5.4 STATA 17.0 were applied analysis. Results Among 10 RCTs involving 811 patients, demonstrated reductions in various parameters: ALT (standardized mean difference (SMD) = − 0.72), 95% confidence interval (Cl) [− 1.01, 0.44], P < 0.00001), AST (SMD 0.79, CI 1.17, 0.40], 0.0001), GGT 0.62, 0.95, 0.29], 0.0002), TG 0.59, 0.86, 0.31], TC(SMD 0.74, 1.00, 0.49], LDL-C 0.53, 0.88, 0.18], 0.003), HDL-C 0.51, 0.12, 1.15], 0.11), HOMA-IR 1.56, 2.54, 0.58], 0.002), BMI 0.58, 0.77, 0.38], 0.00001). Importantly, exhibited favorable profile, only mild gastrointestinal adverse events reported. Conclusion demonstrates berberine's improving enzymes, sensitivity NAFLD patients. These results indicate that shows promise an adjunct therapy Trial registration protocol Registered 27, 2023 Graphical

Language: Английский

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Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Nov. 3, 2021

Traditional Chinese medicine plays a significant role in the treatment of various diseases and has attracted increasing attention for clinical applications. Vascular affecting vasculature heart, cerebrovascular disease, atherosclerosis, diabetic complications have compromised quality life affected individuals increase burden on health care services. Berberine, naturally occurring isoquinoline alkaloid form Rhizoma coptidis , is widely used China as folk its antibacterial anti-inflammatory properties. Promisingly, an number studies identified several cellular molecular targets berberine, indicating potential alternative therapeutic strategy vascular diseases, well providing novel evidence that supports berberine to combat diseases. The purpose this review comprehensively systematically describe agent including pharmacological effects, mechanisms, pharmacokinetics. According data published so far, shows remarkable anti-inflammatory, antioxidant, antiapoptotic, antiautophagic activity via regulation multiple signaling pathways, AMP-activated protein kinase (AMPK), nuclear factor κB (NF-κB), mitogen-activated silent information regulator 1 (SIRT-1), hypoxia-inducible 1α (HIF-1α), endothelial growth phosphoinositide 3-kinase (PI3K), B (Akt), janus 2 (JAK-2), Ca 2+ channels, endoplasmic reticulum stress. Moreover, we discuss existing limitations give corresponding measures. In addition, propose some research perspectives challenges, provide solid base from which further can excavate effective drugs monomers.

Language: Английский

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Berberine as a potential agent for breast cancer therapy

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: Sept. 2, 2022

Breast cancer (BC) is a common malignancy that mainly occurred in women and it has become the most diagnosed annually since 2020. Berberine (BBR), an alkaloid extracted from

Language: Английский

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Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 6, 2022

Berberine (BBR), an isoquinoline alkaloid extracted from Coptidis Rhizoma, has a long history of treating dysentery in the clinic. Over past two decades, polytrophic, pharmacological, and biochemical properties BBR have been intensively studied. The key functions BBR, including anti-inflammation, antibacterial, antioxidant, anti-obesity, even antitumor, discovered. However, underlying mechanisms BBR-mediated regulation still need to be explored. Given that is also natural nutrition supplement, modulatory effects on nutritional immune responses attracted more attention investigators. In this mini-review, we summarized latest achievements inflammation, gut microbes, macrophage polarization, associated with their possible tools pathogenesis therapy ulcerative colitis cancer recent 5 years. We discuss therapeutic efficacy anti-inflammatory actions benefit future clinical applications.

Language: Английский

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Pharmacokinetic of berberine, the main constituent of Berberis vulgaris L.: A comprehensive review

Phytotherapy Research, Journal Year: 2022, Volume and Issue: 36(11), P. 4063 - 4079

Published: Oct. 11, 2022

Abstract Barberry ( Berberis vulgaris L.) is a medicinal plant and its main constituent an isoquinoline alkaloid named berberine that has multiple pharmacological effects such as antioxidant, anti‐microbial, antiinflammatory, anticancer, anti‐diabetes, anti‐dyslipidemia, anti‐obesity. However, it restricted clinical uses due to very poor solubility bioavailability (less than 1%). It undergoes demethylenation, reduction, cleavage of the dioxymethylene group in first phase metabolism. Its two reactions include glucuronidation, sulfation, methylation. The liver site for distribution. Berberine could excrete feces, urine, bile. Fecal excretion (11–23%) higher urinary biliary routes. major metabolite excreted urine greater feces. Concomitant administration with other drugs metformin, cyclosporine A, digoxin, etc. may result important interactions. Thus, this review, we gathered dissected any related animal human research articles regarding pharmacokinetic parameters including bioavailability, metabolism, distribution, excretion, drug–drug Also, discussed various studies developed products better consequently, therapeutic effects.

Language: Английский

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Dietary berberine alleviates high carbohydrate diet-induced intestinal damages and improves lipid metabolism in largemouth bass (Micropterus salmoides)

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Sept. 23, 2022

High carbohydrate diet (HCD) causes metabolism disorder and intestinal damages in aquaculture fish. Berberine has been applied to improve obesity, diabetes NAFLD. However, whether berberine contributes the alleviation of HCD-induced fish is still unclear. Here we investigated effects mechanism on largemouth bass (Micropterus salmoides). We found dietary (50 mg/kg) improved physical indexes (VSI HSI) without affecting growth performance survival rate bass. Importantly, results showed that reduced tissue repaired barrier intestine observed significantly suppressed apoptosis (from 31.21 8.35%) activity level Caspase3/9 (P < 0.05) by alleviating inflammation (il1β, il8, tgfβ, IL-6, P ER stress (atf6, xbp1, perk, eif2α, chopa, chopb, BIP, Further declined excessive lipogenesis (oil red O area, TG content, acaca, fasn, scd, pparγ, srebp1, promoted lipolysis (hsl, lpl, cpt1a, cpt2, via activating adenosine monophosphate-activated protein kinase (AMPK, inhibiting sterol regulatory element-binding 1 (SREBP1, Besides, also hepatic lipid catabolism glycolysis (pk ira, reduce systematic deposition fed with HCD. Therefore, elucidated 50 mg/kg alleviated AMPK/SREBP1-mediated bass, evaluated feasibility for as an aquafeed additive enhance function species.

Language: Английский

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Impact of nanotechnology on the oral delivery of phyto-bioactive compounds

Food Chemistry, Journal Year: 2023, Volume and Issue: 424, P. 136438 - 136438

Published: May 22, 2023

Language: Английский

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A Descriptive Review of the Action Mechanisms of Berberine, Quercetin and Silymarin on Insulin Resistance/Hyperinsulinemia and Cardiovascular Prevention

Molecules, Journal Year: 2023, Volume and Issue: 28(11), P. 4491 - 4491

Published: June 1, 2023

Insulin resistance (IR) and the associated hyperinsulinemia are early pathophysiological changes which, if not well treated, can lead to type 2 diabetes, endothelial dysfunction cardiovascular disease. While diabetes care is fairly standardized, prevention treatment of IR lacks a single pharmaceutical approach many lifestyle dietary interventions have been proposed, including wide range food supplements. Among most interesting well-known natural remedies, alkaloid berberine flavonol quercetin particular relevance in literature, while silymarin—the active principle Silybum marianum thistle—was traditionally used for lipid metabolism disorders sustain liver function. This review describes major defects insulin signaling leading main properties three mentioned substances, their molecular targets synergistic action mechanisms. The actions berberine, silymarin partially superimposable as remedies against reactive oxygen intermediates generated by high-lipid diet NADPH oxidase, which triggered phagocyte activation. Furthermore, these compounds inhibit secretion battery pro-inflammatory cytokines, modulate intestinal microbiota especially able control various receptor post-receptor systems. Although evidence on effects modulating preventing disease derive from experimental studies animals, amount pre-clinical knowledge strongly suggests need investigate therapeutic potential substances human pathology.

Language: Английский

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Plant food bioactives and its effects on gut microbiota profile modulation for better brain health and functioning in Autism Spectrum Disorder individuals: A review

Food Frontiers, Journal Year: 2021, Volume and Issue: 3(1), P. 124 - 141

Published: Dec. 15, 2021

Abstract Recent advances in gut microbiota researches are establishing the association between food, microbiota, and brain health. Previously unknown communication networks inhabiting microbes within linings being uncovered. The nature of interaction is a new frontier research exploration. Diet plays an important role modulating microbiota‐gut‐brain axis exerts profound influence on functioning. This review focuses effect plant food bioactives or phytochemicals profile Autistic individuals, for improving health Autism Spectrum Disorder (ASD) neurodevelopmental disease marked by issues with speech, memory, social behavior. Currently, alarming rise ASD cases among children across globe recorded. has no known cure causes; genetic environmental factor possibly development ASD. Since dietary intervention one most solutions that might bring positive change overall functioning individuals. In this review, associated better individuals its mode action have been explained. Specifically having over functions like behavior, cognition through balancing beneficial to reduce symptoms presented.

Language: Английский

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