Cardiovascular Innovations and Applications,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Jan. 1, 2023
Coronavirus
disease
2019
(COVID-19),
caused
by
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2),
has
rapidly
become
a
global
health
emergency.
In
addition
to
causing
effects,
SARS-CoV-2
can
result
in
cardiac
involvement
leading
myocardial
damage,
which
is
increasingly
being
explored
the
literature.
Myocardial
injury
an
important
pathogenic
feature
of
COVID-19.
The
angiotensin-converting
enzyme-2
receptor
plays
key
role
pathogenesis
virus,
serving
as
“bridge”
allowing
invade
body.
However,
exact
mechanism
underlying
how
causes
remains
unclear.
This
review
summarizes
main
possible
mechanisms
patients
with
COVID-19,
including
direct
cell
injury,
microvascular
dysfunction,
cytokine
responses
and
systemic
inflammation,
hypoxemia,
stress
responses,
drug-induced
injury.
Understanding
would
aid
proper
identification
treatment
Frontiers in Pediatrics,
Journal Year:
2024,
Volume and Issue:
12
Published: Feb. 23, 2024
Background
and
objective
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
has
broad
tissue
tropism
high
transmission,
which
are
likely
to
perpetuate
the
pandemic.
The
study
aim
analyze
clinicopathogenic
characteristics
in
paediatric
patients.
Methods
In
this
single-centre
study,
we
retrospectively
included
all
confirmed
cases
infected
by
SARS-CoV-2
infection
at
Xi’an
Children's
Hospital,
China,
from
1
December
31
2022.
demographic,
clinical,
laboratory,
radiological
features
of
patients
were
analysed.
Results
A
total
4,520
with
omicron
variant
infections
included.
Of
these,
3,861
(85.36%)
outpatients,
659
(14.64%)
hospitalised
patients,
nine
(0.20%)
died.
who
died,
five
diagnosed
necrotising
encephalopathy
(ANE).
most
common
symptoms
fever
4,275
(94.59%)
cough
1,320
(29.20%)
convulsions
610
(13.50%)
vomiting
410
(9.07%)
runny
nose/coryza
277
(6.13%)
hoarseness
voice
273
(6.04%)
blood
cell
analysis
showed
a
slight
elevation
monocytes
(mean:
11.14
±
0.07%).
main
diagnoses
for
both
outpatients
inpatients
multisystem
manifestations.
Conclusions
incidence
is
typical
characteristic
children
SARS-CoV-2.
Five
COVID-19
fatalities
associated
ANE.
This
indicates
that
nervous
system
damage
more
significant.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 9960 - 9960
Published: Sept. 15, 2024
Angiotensin-converting
enzyme
2
(ACE2)
has
become
a
hot
topic
in
neuroscience
research
recent
years,
especially
the
context
of
global
COVID-19
pandemic,
where
its
role
neurological
diseases
received
widespread
attention.
ACE2,
as
multifunctional
metalloprotease,
not
only
plays
critical
cardiovascular
system
but
also
an
important
protection,
development,
and
inflammation
regulation
nervous
system.
The
pandemic
further
highlights
importance
ACE2
SARS-CoV-2
enters
host
cells
by
binding
to
which
may
directly
or
indirectly
affect
system,
leading
range
symptoms.
This
review
aims
explore
function
well
potential
impact
therapeutic
various
diseases,
providing
new
perspective
for
treatment
disorders.
Cardiovascular Innovations and Applications,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Jan. 1, 2023
Coronavirus
disease
2019
(COVID-19),
caused
by
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2),
has
rapidly
become
a
global
health
emergency.
In
addition
to
causing
effects,
SARS-CoV-2
can
result
in
cardiac
involvement
leading
myocardial
damage,
which
is
increasingly
being
explored
the
literature.
Myocardial
injury
an
important
pathogenic
feature
of
COVID-19.
The
angiotensin-converting
enzyme-2
receptor
plays
key
role
pathogenesis
virus,
serving
as
“bridge”
allowing
invade
body.
However,
exact
mechanism
underlying
how
causes
remains
unclear.
This
review
summarizes
main
possible
mechanisms
patients
with
COVID-19,
including
direct
cell
injury,
microvascular
dysfunction,
cytokine
responses
and
systemic
inflammation,
hypoxemia,
stress
responses,
drug-induced
injury.
Understanding
would
aid
proper
identification
treatment
