Ferroptosis: An important mechanism of disease mediated by the gut-liver-brain axis

Life Sciences, Journal Year: 2024, Volume and Issue: 347, P. 122650 - 122650

Published: April 16, 2024

Language: Английский

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The Impact of Microbiota on Neurological Disorders: Mechanisms and Therapeutic Implications

OBM Neurobiology, Journal Year: 2025, Volume and Issue: 09(01), P. 1 - 12

Published: Feb. 28, 2025

Interactions in the gut-brain crosstalk have led to development of an entirely new concept: "microbiota-gut-brain axis". Microbiota has gained considerable attention relation disorders a more neurological nature, such as neurodevelopmental and neuropsychiatric illnesses like autism spectrum disorder, anxiety, mood disorders. This review aims summarize recent trends insights into role consequences gut microbiota brain health pediatric Dysbiosis may be associated with increased risk diseases that lead different disruptions conditions, including mental issues. During dysbiosis, neuropsychological stress hormones usually affect oxytocin GABA neurons are significantly reduced. Current studies report major depression, cognitive dysfunction closely dysbiosis. In last few years, handful clinical emerged, illustrating potential for bidirectional relationship interactions humans. Perhaps some most crucial investigations demonstrating overlapping relationships human axis come from trials focusing on modulating noting significant correlates. A field is emerging gene-editing technology could represent tool improve microbial characteristics. approach particularly relevant neurodegenerative brain-gut linked loss species and/or high pathobiont load.

Language: Английский

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Reshaping the Gut Microbiota: Tangliping Decoction and Its Core Blood-Absorbed Component Quercetin Improve Diabetic Cognitive Impairment

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156560 - 156560

Published: March 5, 2025

Language: Английский

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Enteric nervous system dysfunction as a driver of central nervous system disorders: The Forgotten brain in neurological disease

Neuroscience, Journal Year: 2025, Volume and Issue: 572, P. 232 - 247

Published: March 13, 2025

Language: Английский

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Fructooligosaccharides and Aspergillus enzymes increase brain GABA and homocarnosine by modulating microbiota in adolescent mice

npj Science of Food, Journal Year: 2025, Volume and Issue: 9(1)

Published: April 3, 2025

Language: Английский

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Probiotic Potential of Pediococcus pentosaceus M6 Isolated from Equines and Its Alleviating Effect on DSS-Induced Colitis in Mice

Microorganisms, Journal Year: 2025, Volume and Issue: 13(5), P. 957 - 957

Published: April 22, 2025

Colitis in equines has high morbidity and mortality rates, which severely affects the development of equine-breeding industry. With issuance antibiotic bans, there is an urgent need for healthier more effective alternatives. In recent years, probiotics have been widely used as microbial feed additives animal husbandry, playing a crucial role preventing treating diarrhea regulating host immune function. this study, we isolated screened strain with rapid stable acid production using bromocresol purple, litmus milk coloration tests, performance assessments. Based on morphological characteristics, physiological biochemical properties, 16S rDNA identification, was identified Pediococcus pentosaceus named M6. The M6 exhibited growth tolerance to temperatures, bile salt concentrations, simulated gastrointestinal fluid environments. demonstrated good antibacterial effects against Escherichia coli, Staphylococcus aureus, Salmonella. did not produce hemolysis zones Columbia blood agar plates, indicating its safety, found be insensitive 12 antibiotics, including cephalexin neomycin. Additionally, intervention mice dextran sulfate sodium (DSS)-induced colitis alleviated weight loss shortened colon length. To certain extent, it regulated expression inflammatory cytokines gut microbiota within body reduced cell infiltration intestinal barrier damage. summary, excellent probiotic properties could alleviate DSS-induced mice, suggesting potential application value husbandry.

Language: Английский

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Modulation of gut microbiota with probiotics as a strategy to counteract endogenous and exogenous neurotoxicity

Advances in neurotoxicology, Journal Year: 2024, Volume and Issue: unknown, P. 133 - 176

Published: Jan. 1, 2024

Language: Английский

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Buty and the beast: the complex role of butyrate in Parkinson’s disease

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 17, 2024

Parkinson's disease (PD) is a complex neurodegenerative which often associated with gastrointestinal (GI) dysfunction. The GI tract home to wide range of microorganisms, among bacteria, that can influence the host through various mechanisms. Products produced by these bacteria act in gut but also exert effects brain via what now well established be microbiota-gut-brain axis. In those PD gut-bacteria composition found different non-PD individuals. addition compositional changes, metabolic activity gut-microbiota changed PD. Specifically, it reported key producers short chain fatty acids (SCFAs) as concentration SCFAs themselves are altered stool and blood These SCFAs, butyrate, essential nutrients for major energy source epithelial cells tract. Additionally, butyrate plays role regulating responses particularly relation inflammation. Studies have demonstrated reduction levels critical onset progression Furthermore, has been shown restoring methods such probiotics, prebiotics, sodium supplementation, fecal transplantation beneficial effect on both motor non-motor outcomes disease. This review presents an overview evidence corresponding metabolite production PD, particular focus SCFA butyrate. presenting current studies regarding clinical preclinical reports, possibility target using microbiome based approaches therapeutic context discussed.

Language: Английский

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The Effect of Gut Microbiota-Targeted Interventions on Neuroinflammation and Motor Function in Parkinson’s Disease Animal Models—A Systematic Review

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(5), P. 3946 - 3974

Published: April 26, 2024

Gut microbiome-targeted interventions such as fecal transplant, prebiotics, probiotics, synbiotics, and antibiotic gut depletion are speculated to be of potential use in delaying the onset progression Parkinson’s disease by rebalancing microbiome context gut–brain axis. Our study aims organize recent findings regarding these animal models identify how they affect neuroinflammation motor outcomes. A systematic literature search was applied PubMed, Web Science, Embase, SCOPUS for non-dietary interventions. Studies that investigated gut-targeted using vivo murine PD follow dopaminergic cell loss, tests, neuroinflammatory markers outcomes were considered eligible. total 1335 studies identified databases, out which 29 found narrative systematization resulting data performed, effect direction represented. Quality assessment SYRCLE risk bias tool also performed. Out eligible studies, we a significant majority report intervention reduced loss (82.76%, 95% CI [64.23%, 94.15%]) produced induction model. Also, most reported reduction microglial (87.5%, [61.65%, 98.45%]) astrocytic activation (84,62%, [54.55%, 98.08%]) caused These results mirrored (96.4% [81.65%, 99.91%]) reporting an increase performance behavioral tests. limitation insufficient information assess specific causes bias. show can improve acute models. Further needed clarify if benefits transfer long-term pathogenesis disease, is not yet fully understood. The had no funding source, protocol registered PROSPERO database with ID number CRD42023461495.

Language: Английский

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Microbiome-based therapeutics for Parkinson's disease

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(6), P. e00462 - e00462

Published: Oct. 1, 2024

Language: Английский

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