Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Nov. 18, 2024
Language: Английский
Drug Resistance Updates, Journal Year: 2023, Volume and Issue: 71, P. 101012 - 101012
Published: Oct. 18, 2023
Language: Английский
Citations
97
Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(2), P. 217 - 217
Published: Feb. 18, 2024
Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on previously overlooked player the pathogenesis of disease-the human microbiome. This review article addresses intricate relationship between microbiome infectious unravels its role as crucial mediator host-pathogen interactions. We explore remarkable potential harnessing this dynamic ecosystem develop innovative strategies that could revolutionize management diseases. By exploring latest advances emerging trends, aims provide new perspective combating by targeting
Language: Английский
Citations
23
Microorganisms, Journal Year: 2023, Volume and Issue: 11(8), P. 1912 - 1912
Published: July 27, 2023
The global burden of bacterial resistance remains one the most serious public health concerns. Infections caused by multidrug-resistant (MDR) bacteria in critically ill patients require immediate empirical treatment, which may not only be ineffective due to MDR multiple classes antibiotics, but also contribute selection and spread antimicrobial resistance. Both WHO ECDC consider carbapenem-resistant Enterobacteriaceae (CRE), Pseudomonas aeruginosa (CRPA), Acinetobacter baumannii (CRAB) highest priority. ability form biofilm acquisition drug genes, particular carbapenems, have made these pathogens particularly difficult treat. They are a growing cause healthcare-associated infections significant threat health, associated with high mortality rate. Moreover, co-colonization was found predictor for in-hospital mortality. Importantly, they potential using mobile genetic elements. Given current situation, it is clear that finding new ways combat can no longer delayed. aim this review evaluate literature on how AMR. highlights importance rational use antibiotics need implement stewardship principles prevent transmission drug-resistant organisms healthcare settings. Finally, discusses advantages limitations alternative therapies treatment “titans” antibiotic
Language: Английский
Citations
41
Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10
Published: July 20, 2023
Ulcerative colitis (UC) is presently considered a multifactorial pathology, which may lead to persistent inflammatory action of the gastrointestinal tract (GIT) because an improperly managed immunological reactivity intestinal microbiota found in GIT. The immune response common commensal microbes plays essential role inflammation related UC synbiotics, and it important element optimal therapy UC. Therefore, i.e., mixture prebiotics probiotics, help control diseased state. Synbiotics alleviate colon by lowering reactive oxygen species (ROS) improving level antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), superoxide dismutase (SOD). Prebiotic supplementation not practice at moment, despite numerous research findings proving that benefits both probiotics encourage their continued existence positioning GIT, with positive effects on human health managing response. However, fact there have been fewer studies treatment different coupled selected prebiotics, outcomes these very favorable. This evidence-based study explores possible ROS, SOD, synbiotics proposed review also focuses alteration gut microbiota, defense tract, management Thus, current article emphasizes oxidative stress signaling GI stress-based pathomechanisms patients, therapies inhibiting stress’ effects.
Language: Английский
Citations
31
Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown
Published: June 1, 2024
The human gut hosts a diverse microbial community, essential for maintaining overall health. However, antibiotics, commonly prescribed infections, can disrupt this delicate balance, leading to antibiotic-associated diarrhea, inflammatory bowel disease, obesity, and even neurological disorders. Recognizing this, probiotics have emerged as promising strategy counteract these adverse effects.
Language: Английский
Citations
14
Journal of Fish Diseases, Journal Year: 2024, Volume and Issue: 47(7)
Published: March 24, 2024
Abstract The emergence of antibiotic‐resistant bacteria (ARBs) and genes (ARGs) in aquaculture underscores the urgent need for alternative veterinary strategies to combat antimicrobial resistance (AMR). These measures are vital reduce likelihood entering a post‐antibiotic era. Identifying environmentally friendly biotechnological solutions prevent treat bacterial diseases is crucial sustainability minimizing use antimicrobials, especially antibiotics. development probiotics with quorum‐quenching (QQ) capabilities presents promising non‐antibiotic strategy sustainable aquaculture. Recent research has demonstrated effectiveness QQ (QQPs) against range significant fish pathogens disrupts microbial communication (quorum sensing, QS) by inhibiting production, replication, detection signalling molecules, thereby reducing virulence factors. With their targeted anti‐virulence approach, QQPs have substantial promise as potential application aquaculture, however, still its early stages requires additional research. Key challenges include determining optimal dosage treatment regimens, understanding long‐term effects, integrating other disease control methods diverse systems. This review scrutinizes current literature on antibiotic usage, AMR prevalence mechanisms
Language: Английский
Citations
6
Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown
Published: March 13, 2024
Autochthonous dairy lactic acid bacteria (LAB) isolates encompass a natural source of starter, adjunct, or probiotic candidates. In this context, traditionally manufactured, using exclusively animal rennet, Feta-type cheeses were collected from five farms located in different regions Kefalonia island (Greece). The primary objective study was to isolate and characterize novel LAB, thereby exploring the unmapped microbial communities Kefalonian cheese identifying new potential probiotics. initial screening, included preliminary gastrointestinal (GI) tolerance assessment (acidic conditions bile salts), followed by their safety evaluation (hemolytic activity antibiotic susceptibility). Based on selected strains underwent molecular identification further investigated for attributes (lysozyme phenol resistance, antimicrobial traits, antidiabetic aspects, cholesterol reduction adhesion, adhesion Caco-2 cells, milk acidification potential). results showed that 49, out 93 retrieved isolates, exhibited resistance GI conditions, whereas 18 met criteria. revealed belonging species Lactiplantibacillus plantarum, Limosilactobacillus fermentum, Lacticaseibacillus rhamnosus, paracasei. rod-shaped 14 displayed character. best-performing concerning assimilation α-glucosidase inhibition, epithelial adherence Lpb. plantarum F89, F162, F254 Lcb. paracasei F214 F216, F70 as defined strain starter. present explores first time biodiversity fermented cheese, revealing can contribute development innovative functional food products.
Language: Английский
Citations
5
Food Production Processing and Nutrition, Journal Year: 2022, Volume and Issue: 4(1)
Published: Aug. 1, 2022
Abstract The health benefits associated with probiotics have increased their application in pharmaceutical formulations and functional food development. High production of probiotic biomass requires a cost-effective method nutrient media optimization. can be enhanced by optimizing growth parameters such as substrate, pH, incubation time, etc. For economical industrial biomass, it is required to design new medium low cost. Wastes from the industries are promising components for development low-cost medium. Industrial wastes cheese whey corn steep liquor excellent examples reliable sources nitrogen bacteria. yield reduced cost production. This review focuses on importance its challenges. Graphical
Language: Английский
Citations
21
BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)
Published: May 21, 2024
Abstract Background Research on the advantages of probiotics has attracted increasing interest based number publications, products, and public awareness their benefits. This review evaluated role (single multiple regimens) as an additional regimen to treat common infectious diseases, including Helicobacter. pylori , diarrheal infections, urinary tract infections (UTIs), upper respiratory (URTIs), HIV infections. Methods We searched randomized controlled trials from PubMed, Scopus, Embase, Cochrane identified 6,950 studies. Duplicates were removed, titles abstracts filtered. Bias was using Risk Tool for Randomized Trials (ROB 1.0 2.0). The certainty evidence GRADE. Data extracted meta-analysis performed RevMan. Results A total 32 studies included in this study (22 H. studies, 2 infection 6 UTI studies). There no URTI. Probiotics, addition primary treatment, could improve eradication versus control (RR: 1.09; 95% CI:1.04 − 1.13, p value = 0.001) achieve a cure range Nugent score patients (RR 1.38; CI: 1.01 1.89, 0.04). For eradicating infection, subgroup analysis therapy showed that standard triple slightly superior compared quadruple 1.14 vs. 1.01, respectively). Single strain similar effect probiotic regimens (both had RR 1.09). estimates use single adjuvant high evidence. Meta-analysis not because there only two eligible with different supplementations outcome parameters. Nonetheless, they incidence lower complete remission higher after probiotics. Similarly, used designs comparators contradicting findings. Conclusion beneficial UTI. Probiotic supplementation might be given therapy. Single-strain multi-strain effects rate pylori. Our also suggested benefits remain unclear; more are needed confirm
Language: Английский
Citations
4
Microbiology Research, Journal Year: 2025, Volume and Issue: 16(1), P. 24 - 24
Published: Jan. 17, 2025
The enteric microbiota influences gene expression in the colonic epithelium. H. pylori (Helicobacter pylori) affects gastric growth factors, cytokines, and tumor cell markers, potentially benefiting host. interaction between human is complex but appears beneficial disease development. This publication discusses microbiota, microbiome, chronic colonization, bacterium’s role disease. interplay bacterium during infection also explored. gut has most abundant microbial community performs vital roles food digestion nutrient uptake, extraction of absorbable vitamins, inhibition pathogen colonization. Helicobacter a highly specialized pathogen, predominantly colonizing mucus layer, on or adherent to underlying epithelial surfaces. Many studies have suggested that microbiome related infection, some bacterial species can be used for detection diagnosis infection. Human genome analysis revolutionized our understanding intricate relationship humans their associated communities. integration data displayed promising capabilities occult detection, unveiling previously hidden pathologies providing opportunities early intervention. These groundbreaking discoveries paved way novel therapeutic strategies deeper comprehension interconnected nature overall health.
Language: Английский
Citations
0