Managing Corneal Infections: Out with the old, in with the new?

Antibiotics, Journal Year: 2023, Volume and Issue: 12(8), P. 1334 - 1334

Published: Aug. 18, 2023

There have been multiple reports of eye infections caused by antibiotic-resistant bacteria, with increasing evidence ineffective treatment outcomes from existing therapies. With respect to corneal infections, the most commonly used antibiotics (fluoroquinolones, aminoglycosides, and cephalosporines) are demonstrating reduced efficacy against bacterial keratitis isolates. While traditional methods losing efficacy, several novel technologies under investigation, including light-based anti-infective technology or without chemical substrates, phage therapy, probiotics. Many these show non-selective antimicrobial activity potential development as broad-spectrum agents. Multiple preclinical studies a limited number clinical case confirmed some methods. However, given rapid evolution their requires institution limit impact on vision prevent complications such scarring perforation. Given effects microbial viability, seem particularly promising in this regard.

Language: Английский

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Therapeutic and prophylactic effects of oral administration of probiotic Enterococcus faecium Smr18 in Salmonella enterica-infected mice

Gut Pathogens, Journal Year: 2023, Volume and Issue: 15(1)

Published: May 18, 2023

Salmonella enterica serotype Typhi causes chronic enteric fever known as typhoid. Prolonged treatment regimen used for the of typhoid and indiscriminate use antibiotics has led to emergence resistant strains S. that further increased severity disease. Therefore, alternative therapeutic agents are urgently required. In this study, probiotic enterocin-producing bacteria Enterococcus faecium Smr18 was compared both its prophylactic efficacy in infection mouse model. E. possessed high tolerance bile salts simulated gastric juice, 3 2 h resulted 0.5 0.23 log10 reduction colony forming units, respectively. It exhibited 70% auto aggregation after 24 incubation formed strong biofilms at pH 5 7. Oral administration BALB/c mice infected with significantly (p < 0.05) reduced mortality prevented weight loss mice. Administration prior inhibited translocation liver spleen, whereas, post-infection completely cleared pathogen from organs within 8 days. Further, pre- post-E. faecium-treated groups, sera levels enzymes were restored back normal; whereas creatinine, urea antioxidant untreated-infected group. nitrate by 1.63-fold 3.22-fold post-administration group, Sera interferon-γ highest (tenfold) interleukin-10 group thereby indicating resolution probiotic-treated plausibly due production reactive nitrogen intermediates.

Language: Английский

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Bacillus amyloliquefaciens B10 Alleviates the Immunosuppressive Effects of Deoxynivalenol and Porcine Circovirus Type 2 Infection

Toxins, Journal Year: 2023, Volume and Issue: 16(1), P. 14 - 14

Published: Dec. 27, 2023

As one of the most common mycotoxins, deoxynivalenol (DON) can contaminate a wide range crops and foods. Porcine circovirus 2 (PCV2) is kind immunosuppressive virus, which cause porcine associated disease (PCVD) in pig farms infected with PCV2. Pigs are extremely sensitive to DON, PCV2-infected often contaminated DON. Our previous studies indicated that Bacillus amyloliquefaciens B10 (B10) has potential alleviate toxicity mycotoxins. The research was aimed at investigating effects on caused by both DON PCV2 infection. results expression capsid protein CAP significantly decreased after pretreatment B10. Then, type I interferon, antiviral signal pathway cGAS–STING further investigated. findings displayed interferon were increased, while IL-10 inhibition relieved. Furthermore, it found this intervention effect produced inhibiting autophagy. In summary, mitigate production

Language: Английский

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The Therapeutic Effects of Probiotic on Systemic Lupus Erythematosus in Lupus Mice Models: A Systematic Review

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown

Published: May 28, 2024

Language: Английский

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Microbiome modulators in the treatment of infectious diseases: insights from clinical trials

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 18, 2024

Language: Английский

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