Human immunodeficiency virus and oral microbiota: mutual influence on the establishment of a viral gingival reservoir in individuals under antiretroviral therapy DOI Creative Commons
Diana Estefania Ramos Peña, Sylvie Pillet, Alan Grupioni Lourenço

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: April 10, 2024

The role of the oral microbiota in overall health and systemic diseases has gained more importance recent years, mainly due to effects that are mediated by chronic inflammation caused diseases, such as periodontitis, through microbial communities mouth. infection human immunodeficiency virus (HIV) interacts at tissue level (e.g. gut, genital tract, brain) create reservoirs; modulation gut HIV is a good example these interactions. purpose present review assess state knowledge on (microbiome, mycobiome virome) HIV-infected patients comparison HIV-negative individuals discuss reciprocal influence with periodontitis potential establishment viral gingival reservoir. different clinical biological parameters reviewed including age, immune status, potent antiretroviral therapies, smoking, airway coinfections, all factors can modulate during infection. analysis literature proposed this indicates comparisons available studies difficult their great heterogeneity. However, some important findings emerge: (i) less influenced than infection, although recurrent changes microbiome identified many studies; (ii) severe immunosuppression correlated altered therapies correct partially modifications; (iii) constitutes major factor dysbiosis, which exacerbated patients; its pathogenesis be described reinforcement two conditions, where local dysbiosis periodontal pocket leads inflammation, bacterial translocation destruction supporting tissues, turn enhances an inflammatory environment perpetuates cycle. With objective curing reservoirs future it appears develop further researches aimed defining whether inflamed gingiva serve reservoir periodontitis.

Language: Английский

Global stability and Hopf bifurcation of a delayed HIV model with macrophages, CD4+T cells with latent reservoirs and immune response DOI
Hanane Hmarrass, Redouane Qesmi

The European Physical Journal Plus, Journal Year: 2025, Volume and Issue: 140(4)

Published: April 23, 2025

Language: Английский

Citations

0
Development of a LAMP-Based Diagnostic for the Detection of Multiple HIV-1 Strains DOI Creative Commons
Amy Makler, Massimo Caputi, Waseem Asghar

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(4), P. 157 - 157

Published: March 27, 2024

Since its first appearance in 1981, HIV-1 has remained a global concern. Current methods for diagnosing HIV-1, while effective, are mostly specific to given subtype of and often require expensive equipment highly trained individuals collect process the sample. It is necessary develop sensitive diagnostic method that can be administered with minimal provide better care low-resource settings. Loop-mediated isothermal amplification rapid detecting presence nucleic acid sequences. Herein we report development comparison two different HIV LAMP assays, integrase VPR, as well between TRIZol magnetic beads RNA extraction each assay. Our analysis shows assay was able detect virus from multiple subtypes under 30 min variable limit detection (LOD) dependent on subtype.

Language: Английский

Citations

3
Tat-dependent Conditionally Replicating Adenoviruses Expressing Diphtheria Toxin A for Specifically Killing HIV-1 Infected Cells DOI

Fengfeng Ni,

Kai Hu, Miaomiao Li

et al.

Molecular Therapy, Journal Year: 2024, Volume and Issue: 32(7), P. 2316 - 2327

Published: May 11, 2024

Language: Английский

Citations

3
The Effect of Treatment-Associated Mutations on HIV Replication and Transmission Cycles DOI Creative Commons

Madison M. Johnson,

Carson Everest Jones,

Daniel N. Clark

et al.

Viruses, Journal Year: 2022, Volume and Issue: 15(1), P. 107 - 107

Published: Dec. 30, 2022

HIV/AIDS mortality has been decreasing over the last decade. While promising, this decrease correlated directly with increased use of antiretroviral drugs. As a natural consequence its high mutation rate, treatments provide selection pressure that promotes escape mutants. Individuals may acquire drug-naive strains, or those have already mutated due to treatment. Even within host, affects HIV tropism, where initial infection begins R5-tropic virus, but clinical transition AIDS correlates mutations lead an X4-tropic switch. Furthermore, rate spelled failure for all attempts at effective vaccine. Pre-exposure drugs are currently most drug-based preventatives, their effectiveness is also threatened by viral mutation. From attachment and entry assembly release, steps in replication cycle discussed describe drug mechanisms arise Revealing patterns HIV-1 mutations, effects, coordinated attempt understand control them will current preventative measures treatment options, as well development new ones.

Language: Английский

Citations

12
Human immunodeficiency virus and oral microbiota: mutual influence on the establishment of a viral gingival reservoir in individuals under antiretroviral therapy DOI Creative Commons
Diana Estefania Ramos Peña, Sylvie Pillet, Alan Grupioni Lourenço

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: April 10, 2024

The role of the oral microbiota in overall health and systemic diseases has gained more importance recent years, mainly due to effects that are mediated by chronic inflammation caused diseases, such as periodontitis, through microbial communities mouth. infection human immunodeficiency virus (HIV) interacts at tissue level (e.g. gut, genital tract, brain) create reservoirs; modulation gut HIV is a good example these interactions. purpose present review assess state knowledge on (microbiome, mycobiome virome) HIV-infected patients comparison HIV-negative individuals discuss reciprocal influence with periodontitis potential establishment viral gingival reservoir. different clinical biological parameters reviewed including age, immune status, potent antiretroviral therapies, smoking, airway coinfections, all factors can modulate during infection. analysis literature proposed this indicates comparisons available studies difficult their great heterogeneity. However, some important findings emerge: (i) less influenced than infection, although recurrent changes microbiome identified many studies; (ii) severe immunosuppression correlated altered therapies correct partially modifications; (iii) constitutes major factor dysbiosis, which exacerbated patients; its pathogenesis be described reinforcement two conditions, where local dysbiosis periodontal pocket leads inflammation, bacterial translocation destruction supporting tissues, turn enhances an inflammatory environment perpetuates cycle. With objective curing reservoirs future it appears develop further researches aimed defining whether inflamed gingiva serve reservoir periodontitis.

Language: Английский

Citations

2