Estrogen receptor subtype mediated anti-inflammation and vasorelaxation via genomic and nongenomic actions in septic mice DOI Creative Commons
Luyun Zhang, Hanxing Wan, Mengting Zhang

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: May 17, 2023

Sepsis is a life-threatening disease with high mortality worldwide. Septic females have lower severity and than the males, suggesting estrogen exerts protective action, but nothing known about role of vascular endothelial receptor subtypes in this process. In present study, we aimed to study receptors on mesenteric arterioles normal sepsis mice elucidate underlying mechanisms. was induced by intraperitoneal injection LPS. The changes expression release serum cell supernatant proinflammatory cytokines, including TNF-α, IL-1β IL-6, were measured qPCR ELISA, functions multiple organs analyzed. functional activities mouse determined Mulvany-style wire myograph. phospholipase C (PLC) inositol 1,4,5-trisphosphate (IP3R) cells examined Western blot their characterized Ca2+ imaging. female had higher survival rate male mice, pretreatment E2 for 5 days significantly improved inhibited cytokines septic mice. ameliorated pulmonary, intestinal, hepatic renal organ injuries mice; ER via PLC/IP3R/Ca2+ pathway. E2/ER immediately endothelial-derived hyperpolarization (EDH)-mediated vasorelaxation pathway, which more impaired could rescue acetylcholine (ACh)-induced EDH-mediated through mediates anti-inflammation genomic nongenomic actions sepsis. Mechanistically, activation reduces induces leading amelioration sepsis-induced injury rate.

Language: Английский

Targeting NAT10 protects against sepsis-induced skeletal muscle atrophy by inhibiting ROS/NLRP3 DOI
Chuntao Wang, Yukun Liu, Yongsheng Zhang

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 330, P. 121948 - 121948

Published: July 17, 2023

Language: Английский

Citations

10
Mechanisms of sepsis-induced acute liver injury: a comprehensive review DOI Creative Commons

Yongjing Guo,

Wanxu Guo,

Huimin Chen

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 21, 2025

Sepsis is a severe, often life-threatening form of organ dysfunction that arises from an inappropriately regulated host response to infectious pathogen exposure. As the largest gland in body, liver serves as regulatory hub for metabolic, immune, and detoxification activity. It also early sepsis target such hepatic observed 34-46% patients with sepsis. The precise mechanisms give rise sepsis-induced injury, however, remain incompletely understood. Based on research conducted date, dysregulated systemic inflammation, microbial translocation, microcirculatory abnormalities, cell death, metabolic dysfunction, inflammation may all contribute damage can arise context septicemia. This review was developed provide overview summarizing potential underlying informing selection targets therapeutic intervention providing framework alleviation patient symptoms improvement prognostic outcomes.

Language: Английский

Citations

0
Liver injury in sepsis: manifestations, mechanisms and emerging therapeutic strategies DOI Creative Commons

Xinqi Xu,

Tingyu Yang, Jie An

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 28, 2025

Sepsis is defined as a condition related to infection that manifests with multiorgan dysfunction, representing life-threatening state. Consequently, severe complications frequently occur, liver injury being one of the most prevalent serious sepsis. Liver dysfunction during sepsis serves an independent predictor mortality. This review provides comprehensive overview current research on sepsis-induced (SILI), encompassing clinical manifestations, diagnostic criteria, pathogenesis and therapeutic strategies associated this condition. SILI may manifest hypoxic hepatitis due ischemia shock, cholestasis resulting from abnormal bile metabolism, or duct sclerosis. The pathophysiology involves intricate interactions among inflammatory response, oxidative stress, cell death. All these factors complicate treatment represent potential targets for intervention. Furthermore, addresses limitations inherent in conventional therapies currently employed managing emphasizes novel targeted aimed at addressing fundamental mechanisms underlying

Language: Английский

Citations

0
Unraveling the mechanisms of NINJ1-mediated plasma membrane rupture in lytic cell death and related diseases DOI
Jiajia Yang,

Chun Luo,

Kunbo Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 309, P. 143165 - 143165

Published: April 15, 2025

Language: Английский

Citations

0
Can pyridoxine function as an anti-pyroptosis agent? A narrative review DOI
Astari Pranindya Sari, Reviono Reviono, Agus Dwi Susanto

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
Advances in neutrophil extracellular traps and ferroptosis in sepsis-induced cardiomyopathy DOI Creative Commons

Man Zeng,

Youhong Niu, Jiahao Huang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Sepsis-induced cardiomyopathy is a reversible non-ischemic acute cardiac dysfunction associated with sepsis. It strongly an abnormal immune response. emerges as vital threat to public health owing its high mortality rate. However, the exact pathogenesis requires further investigation. In recent years, NETosis and ferroptosis, which are novel modes of programmed cell death, have been identified found play important roles in sepsis-related organ damage. This article outlines mechanisms these two discusses role neutrophil extracellular traps myocardial injury importance ferroptosis sepsis-induced cardiomyopathy, reviews potential interconnection between types death cardiomyopathy.

Language: Английский

Citations

0
Activación de muerte celular en sepsis y Síndrome de Dificultad Respiratoria Aguda (SDRA) DOI Creative Commons
Valeria Sanclemente-Cardoza, Leonor Victoria Moreno Heredia, Harold Andrés Payán-Salcedo

et al.

Medicina, Journal Year: 2025, Volume and Issue: 46(3), P. 788 - 798

Published: Jan. 23, 2025

La sepsis es un síndrome clínico caracterizado por una respuesta sistémica ante agentes microbianos que pueden desencadenar el de dificultad respiratoria aguda (SDRA), conllevando a elevada tasa mortalidad. En contexto la y SDRA, se intensifican las respuestas inflamatorias descontroladas, lo resulta en lesiones mayor producción mediadores inflamación. Esto aumenta demanda oxígeno nivel celular, cual provoca liberación óxido nítrico concentraciones elevadas especies reactivas (ROS). Estos procesos causan perturbaciones mitocondrias, afectando captación del calcio intracelular, desencadena disfunción fosforilación oxidativa (OXPHOS) y, última instancia, reduce ATP. Estas fisiológicas activan diversas vías señalización conducen muerte exacerbando inflamatoria agravando manifestaciones clínicas huésped, riesgo El propósito esta revisión describir activación celular aguda.

Citations

0
N6-methyladenosine modification: Regulatory mechanisms and therapeutic potential in sepsis DOI Open Access
Wei Wang, Huaili Wang, Tongwen Sun

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115719 - 115719

Published: Oct. 14, 2023

Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection and characterized multiple biological clinical features. N6-methyladenosine (m6A) modification the most common type of RNA modifications in eukaryotes plays an important regulatory role various processes. Recently, m6A has been found be involved regulation immune responses sepsis. In addition, several studies have shown that sepsis-induced dysfunctions, including cardiovascular dysfunction, acute lung injury (ALI), kidney (AKI) etc. Considering complex pathogenesis sepsis lack specific therapeutic drugs, may bond pathophysiological process even targets. This review systematically highlights recent advances regarding roles sheds light on their use as treatment targets for

Language: Английский

Citations

8
Current insight on the mechanisms of programmed cell death in sepsis-induced myocardial dysfunction DOI Creative Commons

An-Bu Liu,

Shujing Li, Yuanyuan Yu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11

Published: Dec. 15, 2023

Sepsis is a clinical syndrome characterized by dysregulated host response to infection, leading life-threatening organ dysfunction. It high-fatality condition associated with complex interplay of immune and inflammatory responses that can cause severe harm vital organs. Sepsis-induced myocardial injury (SIMI), as complication sepsis, significantly affects the prognosis septic patients shortens their survival time. For sake better administrating hospitalized it necessary understand specific mechanisms SIMI. To date, multiple studies have shown programmed cell death (PCD) may play an essential role in offering new strategies insights for therapeutic aspects This review aims elucidate cardiomyocyte’s pathophysiological SIMI, particular focus on classical pathways, key molecules, signaling transduction PCD. will explore cross-interaction between different patterns PCD providing theoretical basis multi-target treatments

Language: Английский

Citations

8
Estradiol as the Trigger of Sirtuin-1-Dependent Cell Signaling with a Potential Utility in Anti-Aging Therapies DOI Open Access
Kamil Karolczak, Cezary Watała

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 13753 - 13753

Published: Sept. 6, 2023

Aging entails the inevitable loss of structural and functional integrity cells tissues during lifetime. It is a highly hormone-dependent process; although, exact mechanism hormone involvement, including sex hormones, unclear. The marked suppression estradiol synthesis menopause suggests that may be crucial in maintaining cell lifespan viability women. Recent studies also indicate same true for men. Similar anti-aging features are attributed to sirtuin 1 (SIRT1), which possibly linked at molecular level with estradiol. This finding valuable understanding aging process, its regulation, possible prevention against unhealthy aging. following article summarizes initial published this field focus on age-associated diseases, like cancer, cardiovascular disease atherogenic metabolic shift, osteoarthritis, osteoporosis, muscle damage, as well neurodegenerative neuropsychiatric diseases.

Language: Английский

Citations

8