Oral Microbiota Associated with Clinical Efficacy of Ustekinumab in Crohn’s disease DOI Creative Commons
Feiyang Xu, Rui Xie,

Le He

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 9, 2024

Abstract Crohn’s disease (CD) is a chronic inflammatory gastrointestinal disease. Ustekinumab (UST) has been utilized as therapeutic option for CD patients. However, approximately 40–60% of patients exhibit an inadequate response to UST. Accumulating evidence confirmed the involvement oral bacteria in development CD. Nevertheless, relationship between microbiota and efficacy UST therapy remained unexplored. We recruited 28 healthy controls (HC) 53 patients, 47 whom completed entire therapy. Oral samples clinical data were collected. The remission defined based on CDAI score. analyzed by 16S rRNA gene sequencing. analysis sequence was performed QIIME R. revealed microbial difference HC group group. enrichment Fusobacteria, Leptotrichia, Capnocytophaga, Campylobacter, diminution Haemophilus Rothia, observed Differences also identified among with different Compared group, significantly higher abundance Fusobacteria Leptotrichia both nonresponse nonremission Predictive models constructed microbiota, AUC value 0.944 0.930, respectively. relevant predictive model. It could be considered non-invasive prognostic biomarker

Language: Английский

Polymicrobial interactions of Helicobacter pylori and its role in the process of oral diseases DOI Creative Commons

Y.F. Fan,

Xi Chen, Tiantian Shan

et al.

Journal of Oral Microbiology, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 25, 2025

Objective Helicobacter pylori (H. pylori) infection affects approximately 50% of the global population. The predominant route H. transmission is through oral pathway, making cavity highly significant in its infection. This review focuses on relationship between and diseases, influence microbiota, potential mechanisms involving certain pathogens.

Language: Английский

Citations

0
Enrichment of Porphyromonas gingivalis in colonic mucosa-associated microbiota and its enhanced adhesion to epithelium in colorectal carcinogenesis: Insights from in vivo and clinical studies DOI Creative Commons

Shunya Motosugi,

Naoki Takahashi,

Shuhei Mineo

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0320383 - e0320383

Published: March 25, 2025

Objectives The oral–gut axis is believed to play a role in the pathogenesis of colorectal cancer (CRC). Previous studies have demonstrated transmission oral microbiota gut, disrupting gut microbial balance and creating protumorigenic microenvironment conducive CRC progression. Fusobacterium nucleatum putative periodontal pathogen recognized as specific bacterium that promotes development. However, possible involvement other pathogens poorly understood. This study aimed explore effects ingested on experimental mice elucidate underlying mechanisms. Methods In this study, colitis-induced mouse models were used. orally administered ( Porphyromonas gingivalis Prevotella intermedia ) three times week during period. severity between P. -treated groups was compared. Lumen-associated (LAM) mucosa-associated (MAM) analyzed both human samples. vitro conducted using intestinal epithelial cells mechanisms by which affect Results group exhibited significantly increased compared among azoxymethane/dextran sodium sulfate (AOM/DSS)-induced models. LAM MAM distinct bacterial compositions, enriched more than LAM. adhesion assays revealed had higher adhesive capacity indicated gingipains such capacity. Conclusion MAM, its subsequent potentially involved progression CRC.

Language: Английский

Citations

0
Scientometric Analysis of Research on Oral and Gut Microbiota and Periodontitis: Collaborative Networks, Emerging Patterns, Thematic Evolution DOI Open Access

Frank Mayta-Tovalino,

Fran Espinoza-Carhuancho,

M. Cruz

et al.

The Journal of Contemporary Dental Practice, Journal Year: 2025, Volume and Issue: 26(1), P. 86 - 92

Published: March 28, 2025

To perform a scientometric analysis of scientific literature related to microbiota and periodontitis. A search strategy was applied on 21 July 2024, identifying 1,069 papers from 408 different sources. However, nine articles could not be exported SciVal due incomplete metadata. The documents, including 722 articles, 282 reviews, 44 book chapters, among others, showed an annual growth rate 7.53%. Bibliometrix were used for data extraction analysis. total sources, published between 2019 identified. most frequent terms in the research "periodontitis", "oral microbiome", "microbiome", "periodontal disease", "dysbiosis". According Lotka's Law, authors field contributed small number papers. cited journals this "Frontiers Cellular Infection Microbiology", "Journal Oral "Periodontology 2000". Analysis thematic evolution shows increasing intersection topics recent research, reflecting multifaceted nature periodontitis its interaction with variety other health factors. Research is multifaceted, interacts factors, growing research. This study presents detailed review gut periodontitis, notes current developments, gives hints regarding still emerging themes. Its findings may serve continue future guidelines or understand relationship How cite article: Mayta-Tovalino F, Espinoza-Carhuancho Huaman-De la Cruz M, et al. Scientometric Gut Microbiota Periodontitis: Collaborative Networks, Emerging Patterns, Thematic Evolution. J Contemp Dent Pract 2025;26(1):86-92.

Language: Английский

Citations

0
Oral and intestinal flora translocation and tumor development DOI Open Access

Zhiyuan Ye,

Li Gao, Zhi Guo

et al.

Journal of Cancer Research and Therapeutics, Journal Year: 2025, Volume and Issue: 21(2), P. 323 - 333

Published: May 1, 2025

ABSTRACT Cancer metastasis is the leading cause of death in patients. In recent years, there has been a growing recognition role tumor-associated microflora tumor metastasis. The connection between oral and gut microenvironment also extensively studied. migration closely associated with development. Although awareness regarding significant impact microbial communities on human health, focus their relationship host organisms, particularly those related to microflora, remains inadequate. As an integral part body, crucial for regulating cancer risk preventing recurrence. oral-gut axis plays indispensable immunity, many types cancers, such as colorectal, pancreatic, breast, are significantly influenced by internal communities. However, further exploration into mechanisms underlying intratumoral necessary achieve comprehensive understanding. We have summarized analyzed articles PubMed. This article reviews immune system, explores translocation intestinal flora microenvironment, analyzes specific involved during evolution progression tumors, elaborates correlations occurrence development tumors changes microflora. Finally, summary these abovementioned points provided.

Language: Английский

Citations

0
Genetic evidence strengthens the connection between gut microbiota and gingivitis: a two-sample Mendelian randomization study DOI Creative Commons
Hang Zhou,

Chen Rouyi,

Sen Li

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: May 15, 2024

The oral cavity and gut tract, being interconnected rich in microbiota, may have a shared influence on gingivitis. However, the specific role of distinct microbiota taxa gingivitis remains unexplored. Utilizing Mendelian Randomization (MR) as an ideal method for causal inference avoiding reverse causality potential confounding factors, we conducted comprehensive two-sample MR study to uncover genetic impact

Language: Английский

Citations

2
Causal Link between Gut Microbiota, Neurophysiological States, and Bone Diseases: A Comprehensive Mendelian Randomization Study DOI Open Access
Shaoting Luo, Zhiyang Chen,

Linfang Deng

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(18), P. 3934 - 3934

Published: Sept. 11, 2023

Increasing evidence highlights a robust correlation between the gut microbiota and bone diseases; however, existence of causal relationship them remains unclear. In this study, we thoroughly examined skeletal diseases using genome-wide association studies. Linkage disequilibrium score regression Mendelian randomization were used to probe genetic causality. Furthermore, potential mediating role neuropsychological states (i.e., cognition, depression, insomnia) was evaluated mediation analysis, with colocalization analysis revealing targets. These findings suggest direct Ruminococcaceae knee osteoarthritis (OA), which appears be mediated by cognitive performance insomnia. Similarly, observed Burkholderiales lumbar pelvic fractures, performance. Colocalization identified shared variant (rs2352974) at TRAF-interacting protein locus for ability OA. This study provides compelling that alterations in can enhance ability, ameliorate insomnia, potentially reduce risk site-specific fractures Therefore, strategies targeting optimization could serve as novel effective preventive measures against

Language: Английский

Citations

6
High-Throughput Combined Analysis of Saliva Microbiota and Metabolomic Profile in Chinese Periodontitis Patients: A Pilot Study DOI
Jing Ding, Jinyu Li, Chi Zhang

et al.

Inflammation, Journal Year: 2023, Volume and Issue: 47(3), P. 874 - 890

Published: Dec. 26, 2023

Language: Английский

Citations

6
Macrophage migration inhibitory factor-mediated mast cell extracellular traps induce inflammatory responses upon Fusobacterium nucleatum infection DOI Creative Commons
Hiroyuki Tada, Takashi Nishioka,

R. Ishiyama

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2023, Volume and Issue: 674, P. 90 - 96

Published: June 29, 2023

Language: Английский

Citations

4
Genetic Connectivity of Gut Microbiota and Oral Ulcers: A Mendelian Randomization Study DOI Creative Commons

Bilun Jin,

Pengfei Wang, Peiqi Liu

et al.

International Dental Journal, Journal Year: 2024, Volume and Issue: 74(4), P. 696 - 704

Published: March 7, 2024

The aim of this study was to reveal the relationship, if any, between gut microbiota and oral ulcers. We performed a 2-sample Mendelian randomization (MR) estimate roles in mouth summary datasets were from largest genome-wide association (GWAS) conducted by MiBioGen, data ulcers obtained UK Biobank. Random effect inverse variance-weighted, weighted median, MR Egger, simple mode used relationship. Sensitivity analyses assess heterogeneity pleiotropy instrumental variables. Steiger filtering also applied orient causal direction. Three taxa positively associated with ulcers: Holdemania (odds ratio [OR] = 1.005, 95% confidence interval [CI]: 1.001-1.009, P .019), Oxalobacter (OR 1.004, CI: 1.000-1.007, .032), Ruminococcaceae UCG011 1.006, 1.001-1.011, .029), while 4 negatively Actinobacteria 0.992, 0.985-1.000, .042), Lactobacillales 0.995, 0.990-1.000, .034), Oscillospira 0.990, 0.984-0.997, .007) Phascolarctobacterium 0.986-0.997, .003). validated robustness between. This identified strong quality findings are likely expand therapeutic targets for

Language: Английский

Citations

1
Relationship between periodontal diseases and non-specific inflammatory bowel diseases – an overview. Part I DOI Creative Commons
Małgorzata Goździewska, Aleksandra Łyszczarz, Monika Kaczoruk

et al.

Annals of Agricultural and Environmental Medicine, Journal Year: 2024, Volume and Issue: 31(1), P. 1 - 7

Published: March 21, 2024

1. Sheng JA, Bales NJ, Myers SA, Bautista AI, Roueinfar M, Hale TM, Handa RJ. The hypothalamic-pituitary-adrenal axis: development, programming actions of hormones, and maternal-fetal interactions. Front Behav Neurosci. 2021;14:256. CrossRef Google Scholar

Language: Английский

Citations

1