EFFECT OF MICROAMPERE CURRENT ON CLINICAL STRAINS OF ACINETOBACTER BAUMANNII WITH MULTIPLE DRUG RESISTANCE AND THE MANIFESTATION OF THE BIOELECTRIC EFFECT

Bulletin of Problems Biology and Medicine, Journal Year: 2025, Volume and Issue: 1(1), P. 382 - 382

Published: Jan. 1, 2025

Language: Английский

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Genomic characteristics, virulence potential, antimicrobial resistance profiles, and phylogenetic insights into Nocardia cyriacigeorgica

Annals of Clinical Microbiology and Antimicrobials, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 5, 2025

Nocardia cyriacigeorgica, an opportunistic pathogen, is increasingly implicated in human infections. This pathogen predominantly causes pulmonary infections, leading to acute, subacute, or chronic necrotizing suppurative lesions, severe cases, may progress disseminated Effective clinical diagnosis, prevention, and treatment strategies require a thorough understanding of its biological characteristics pathogenic mechanisms. However, despite the rising incidence nocardial diseases, research on pathogenicity N. cyriacigeorgica remains limited, primarily focusing case reports epidemiological studies. study aimed provide comprehensive analysis genomic features, phylogenetic relationships, antimicrobial resistance profiles, candidate virulence factors strains inform future investigations into pathogenesis. Whole-genome sequencing was conducted five isolated from patients with infection at our hospital. utilized combination second-generation Illumina HiSeq third-generation PacBio technologies. Additionally, publicly available data 58 National Center Biotechnology Information database were integrated, resulting dataset 63 genomes. These genomes subjected comparative analyses, including reconstruction, pan-genome evaluation, gene distribution assessments. Phylogenetic identified major clades within cyriacigeorgica. ANI further subdivided clade B distinct subgroups. Pan-genome revealed clade-specific orthogroups genes assigned Clusters Orthologous Groups, A containing highest number families. Comparative uncovered several potential host cell invasion, phagosomal maturation arrest, intracellular survival macrophages, which conserved across all analyzed strains. Notable differences enterobactin-encoding observed among clades. The mce3C also displayed variable distributions clades; however, no correlation established between presence strain source. Among strains, 27 found harbor both mce4F genes, categorized patterns. Furthermore, antibiotic VanSO, VanRO, erm(O)-Irm, srmB, ermH, bcl, bla1, cmIR, demonstrated Notably, ermH associated isolation origin provides evaluation characteristics, factors, relationships findings offer valuable insights mechanisms underlying survival, replication pathogen-host interactions results establish foundation for pathogenesis management

Language: Английский

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Host–microbe interactions in the lung and the role of immunometabolism

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 7 - 26

Published: Jan. 1, 2025

Language: Английский

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Exploring the Bioactive Properties and Potential Probionts in the Fish Mucosa

Journal of Bacteriology and Virology, Journal Year: 2025, Volume and Issue: 55(1), P. 26 - 41

Published: March 31, 2025

Language: Английский

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Thiazole derivatives as promising antimicrobial and antioxidant agents: insights from synthesis, bioactivity, and computational studies

Journal of Sulfur Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: April 24, 2025

Language: Английский

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