Causality between gut microbiota and gastroesophageal reflux disease: A two-sample Mendelian randomization analysis DOI Creative Commons

Ti Yang,

Zengxin Ma,

Fang Liu

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 31, 2023

Abstract Background Studies have provided evidence of alterations in the diversity and composition gut microbiota individuals with Gastroesophageal reflux disease (GERD). However, causality between GERD remains uncertain. Methods Summary data on were obtained from publicly available genetic databases analyzed by using two sets instruments. MR analyses conducted inverse variance weighted (IVW; primary method for causal inference TSMR analysis), median, Egger, mode methods. Results analysis revealed that 8 bacterial taxa, including 4 risk factors protective factors, associated GERD. IVW results showed was negatively family Bifidobacteriaceae (P = 0.026), order Bifidobacteriales 0.002), Christensenellaceae 0.000), genus Odoribacter 0.024). Conversely, it positively class Mollicutes 0.003), phylum Tenericutes Rikenellaceae 0.015), Prevotella 9 0.013). Reverse did not reveal a reverse relationship microbiota. Conclusions We established association GERD, thus providing groundbreaking perspective studying pathogenesis potential strategies its prevention treatment.

Language: Английский

Causal Effects of Gut Microbiota on Oral Cavity Cancer— A Two-Sample Mendelian Randomization Study DOI Creative Commons
Yuwei Dai,

Ruohui MAO,

Yitong Chen

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 8, 2024

Abstract Background Recent studies have found that there is a certain correlation between gut microbiota (GM) and oral cavity cancer (OCC). However, their causality unclear. This study aimed to evaluate the causal relationship GM OCC identify specific pathogenic microbial taxa. Materials Methods In this Two-Sample Mendelian Randomization Study,GWAS of microbiome from MiBioGen consortium (18,340 samples 24 population-based cohorts) were used as exposure data. addition, outcome data (357 cases 372,016 controls) extracted IEU Open GWAS project. To examine characteristics potentially bacteria in OCC, we performed two-sample randomization (MR) analyses-based genome-wide association (GWAS) summary statistics with use inverse-variance-weighting or Wald ratio. Subsequently, sensitivity analyses explore robustness primary results. Finally, reverse MR analysis mitigate causality. Result A total 2,699 single nucleotide polymorphisms (SNPs) associated 196 bacterial genera screened instrumental variables (IVs), results suggested following taxonomic groups could increase risk OCC: order. Burkholderiales , Bacillales class. Betaproteobacteria genus. Desulfovibrio Pasteurellales family. Pasteurellaceae Eubacteriumfissicatenagroup Alcaligenaceae LachnospiraceaeUCG004 Prevotella7 Peptococcus .Conversely, Butyrivibrio Eggerthella Clostridiumsensustricto1 Clostridiaceae1 phylum. Lentisphaerae exhibited protective effect against OCC. Conclusion Bacillus orders, phylums Proteobacteria are an increased occ, while Genus Butyrivibrio, genus Eggerthella, Clostridium reduce development. Our supports potential several but how affects development remains be further explored.

Language: Английский

Citations

0
Intestinal flora and ulcerative colitis: A Mendelian Randomization study DOI Creative Commons

Fanfan Qu,

Ming Cheng, Hongxia Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 12, 2024

Abstract A large body of clinical data and observational studies suggest that intestinal flora is associated with ulcerative colitis (UC). However, the causal relationship between gut UC remains to be determined. To investigate potential UC, a two-sample Mendelian randomization (MR) analysis was performed in this study. We obtained genome-wide association for from published GWAS databases dual sample MR using inverse variance weighting (IVW) identify beneficial or deleterious flora. Sensitivity analysis, including multi potency heterogeneity assays, validate stability primary assays. In study, we found negative correlation three genera bacteria risk developing into floras. They include Genus Butyrivibrio [OR = 0.908, 95%CI (0.835, 0.987), P 0.0229]; Clostridiuminnocuumgroup 0.847, (0.752, 0.955), 0.00646]; Lactococcus 0.886, (0.796, 0.986), 0.0263]. The pleiotropy showed MR-Egger regression intercept > 0.05 all three, Q-pval indicating there no above-mentioned bacterial groups. This study expands provides theoretical basis further relevant experiments studies.

Language: Английский

Citations

0
Intestinal microbiota and gallstone disease – is there a connection? DOI
В. А. Ахмедов

Medical alphabet, Journal Year: 2024, Volume and Issue: 5, P. 23 - 26

Published: May 7, 2024

Cholelithiasis is a fairly common disease of the digestive system, affecting from 10 % to 15 adult population. Despite many studies devoted this problem, mechanisms formation gallstone have not been fully elucidated. Recently, aspects influence intestinal microbiota on various pathologies gastrointestinal tract such as non-alcoholic fatty liver disease, inflammatory bowel diseases, irritable syndrome, pancreatic gastroesophageal reflux considered. The presented review article examines possible involvement microbiome in pathogenesis disease. discusses role microorganisms and their metabolites gallstones.

Language: Английский

Citations

0
Causal associations between gut microbiota and chronic prostatitis/chronic pelvic pain syndrome: a two-sample Mendelian randomization study DOI Creative Commons
Hao Xu, Yu Zhang, Yinglang Zhang

et al.

Egyptian Journal of Medical Human Genetics, Journal Year: 2024, Volume and Issue: 25(1)

Published: June 21, 2024

Abstract Background Recent researches have increasingly indicated a strong correlation between the gut microbiota and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Nevertheless, impact of on CP/CPPS still requires further elucidation. Methods Employing summary statistics provided by MiBioGen consortium, we executed two-sample Mendelian randomization (MR) analysis. The study involved 18,340 participants considered as instrumental variable. Chronic prostatitis statistics, representing 500 cases 208,308 controls, were extracted from GWAS Catalog release data disease outcome. Various methods, including weighted inverse variance, MR-Egger median, employed to assess how interact correlate with CP/CPPS. Sensitivity analysis was used eliminate heterogeneity horizontal pleiotropy. Results Our findings, primarily derived IVW approach, evidence for causal link five categories Resultantly, genus Christensenellaceae (OR = 0.39, 95% CI 0.17–0.87, P 0.02), Eisenbergiella 0.62, 0.40–0.97, 0.04), Hungatella 0.49, 0.28–0.85, 0.01) Terrisporobacter 0.20–0.75, 0.00) exhibited protective CP/CPPS, while family Prevotellaceae 1.78, 1.01–3.15, 0.05) had opposite effect. No notable variables or pleiotropy detected. Conclusions findings this study, which indicate This could be valuable in offering fresh perspectives additional mechanistic clinical investigations microbiota-related randomized controlled trials are necessary validation.

Language: Английский

Citations

0
Causal relationship between gut microbiota and male erectile dysfunction: a Mendelian randomization analysis DOI Creative Commons

Shuaiqi Chen,

Xiaolong Liu,

Shangrong Wu

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 29, 2024

Background Several observational studies have reported an association between gut microbiota and male erectile dysfunction (ED). However, it remains unclear whether there is a causal relationship ED. Thus, we aimed to investigate the potential ED through Mendelian randomization (MR) analysis. Objective To assess ED, performed two-sample MR Methods We obtained genome-wide (GWAS) data from MiBioGen consortium publicly available GWAS on OPEN database. Subsequently, analysis evaluate Finally, sensitivity analysis, including Cochran’s Q test, MR-Egger intercept MR-PRESSO, leave-one-out level of heterogeneity horizontal pleiotropy in results. Results Our revealed negative genus Ruminococcaceae UCG013 (OR = 0.761, 95% CI 0.626–0.926), while family Lachnospiraceae, Lachnospiraceae NC2004 group, Oscillibacter, Tyzzerella3 may be associated with increased risk highest observed for 1.264, 1.063–1.504). Furthermore, confirmed reliability our positive findings. Conclusion This contribute better understanding applications occurrence treatment

Language: Английский

Citations

0
Exploring the potential link between gut microbiota and chronic kidney disease in causality: A 2-sample Mendelian randomization study DOI Creative Commons

Wen Wen Zhang,

Junhaohui Huo,

Min Xiao

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(43), P. e40236 - e40236

Published: Oct. 25, 2024

Increasing evidence indicates a significant correlation between gut microbiota (GM) and susceptibility to chronic kidney disease (CKD). However, causal relationship presence remains uncertain. Mendelian randomization (MR) was applied evaluate potential relation from GM CKD. Genomic association analysis aggregates publicly online databases, utilizing Genome-Wide Association Study (GWAS) database focused on For examination of connection CKD, 2-way, 2-sample method applied. Sensitivity analyses were utilized scrutinize for heterogeneity, horizontal pleiotropy, MR outcomes resilience. Result inverse variance weighting (IVW) revealed that 10 microbiotas such as Porphyromonadaceae (OR = 1.351, 95% CI: 1.114–1.638, P .002), Dorea 1.236, 1.040–1.468, .016), Ruminococcus torques group 1.290, 1.035–1.608, .024) are CKD risk factors. Five microbiotas, including the Prevotellaceae 0.814, 0.719–0.922, .001) protective reveal no pleiotropy or heterogeneity. Additionally, reverse results unveiled disorders in 3 Senegalimassilia . According investigation, employed delve into reciprocal Our findings identified 15 types causally linked well demonstrating associations with GM. Further exploration these associated is hopeful raise novel insights, preventing early monitoring.

Language: Английский

Citations

0
Neither cholelithiasis nor cholecystectomy is causally associated with colorectal cancer: A univariate and multivariate mendelian randomization study DOI Creative Commons
Qiong Qin, Yong Zhou, Ao Ren

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Abstract Background Epidemiological studies reported controversial results regarding the relationship between cholelithiasis, cholecystectomy and colorectal cancer (CRC). In presence of reverse causality confounding factors, findings our previous retrospective study that it was gallbladder disease rather than a risk factor for not sufficiently convincing. Therefore, we used Mendelian randomization (MR) to further explore cholelithiasis or CRC. Methods We performed univariate MR (UVMR) multivariate (MVMR) analysis 1,054,773 samples 37,970,958 SNPs from three European genome-wide association (GWAS) The forward analysis, with as exposure CRC outcome, included UVMR MVMR analysis. UVMR, 21 30 independent strongly (P < 5*10− 8) associated on were extracted valid instrumental variables (IVs); in MVMR, 14 26 IVs extracted, respectively. inverse only MVMR. 9 7 estimated using multiplicative random effects-inverse variance weighted (MRE-IVW), simple mode (SM), median (WME), (WMO) MR-Egger regression methods, Sensitivity heterogeneity test, pleiotropy test leave-one-out test. presented scatter plots, forest plots funnel plots. Results neither nor by MRE-IVW revealed causal (OR = 1.0002, 95% CI 0.999–1.001, P 0.729 OR 1.0003, 0.998–1.003, 0.799, respectively) 0.9917, 0.963–1.022, 0.582 0.9897, 0.936–1.046, 0.715, respectively). estimates also little evidence 0.0504, 0.001–2.871, 0.147) 0.9894, 0.792–1.236, 0.925). other estimation methods consistent MRE-IVW. confirmed stability reliability results. Conclusions Our two-sample causally cancer.

Language: Английский

Citations

0
Assessing the causal relationship between gut microbiota and prostate cancer: a two-sample Mendelian randomization study DOI Creative Commons
Yijie Wang,

Zhaohui Long,

Yulong Hong

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 23, 2023

Abstract Background Numerous studies indicate that the gut microbiome is closely associated with prostate cancer (PCa), however, owing to various confounding factors, causal relationship between microbiota and PCa remains unclear. Methods A two-sample Mendelian randomization (MR) analysis utilized genome-wide association study (GWAS) data on of 18,340 participants GWAS summary statistics involving 46,3010 participants. Inverse variance weighted (IVW) served as primary method, complemented by MR-Egger median method (WME), simple mode (SM), (WM). Finally, confirm robustness results, heterogeneity test, pleiotropy leave-one-out sensitivity test were conducted. Results IVW revealed 12 microbial taxa potentially causally PCa; genera Victivallis, Akkermansia, Odoribacter, Butyrivibrio, families Enterobacteriaceae, Verrucomicrobiaceae, well orders Verrucomicrobiales, Enterobacteriales class Verrucomicrobiae, found be positively risk. Conversely, Eubacterium ruminantium group, Candidatus Soleaferrea, RuminococcaceaeUCG003 negatively Conclusions Our MR study's results support a genetically predicted PCa, they identify specific taxa. These findings could offer new targets for screening treatment.

Language: Английский

Citations

1
The management of a duodenal fistula involving the right hepatic duct: a rare case report DOI Creative Commons
Ming Qiu,

Jun Yang,

Luo Nai-wen

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 1, 2024

The formation of an internal fistula between the biliary system and gastrointestinal tract is a rare condition with various etiologies, predominantly associated recurrent chronic inflammation tumors. Patients this may lack specific clinical manifestations, presenting symptoms such as abdominal pain, fever, jaundice, or show no signs at all. Common types fistulas include cholecystoduodenal fistula, cholecystocolonic choledochoduodenal fistula. Among these, right hepaticoduodenal extremely seldom reported in literature. We herein report case analyze its mechanism, treatment principles, preventive measures through literature review.

Language: Английский

Citations

0
The Associations between Intestinal Flora and Disease Occurrence Risk: A Systematic Review and Meta-Analysis DOI
Guoheng Jiang, Hongyu Li, Linjun Xie

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0