Synergistic Effects of Probiotics and Lifestyle Interventions on Intestinal Microbiota Composition and Clinical Outcomes in Obese Adults

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 70 - 70

Published: Jan. 23, 2025

Background and objective: Obesity is a growing global epidemic. The composition of the intestinal microbiota can be influenced by several factors. Studies highlight role bacteria in pathophysiology obesity. So, objective this study was to investigate whether use probiotics, together with healthy lifestyle habits, contributes weight reduction obese individuals analyzing profile. Methods: A prospective carried out 45 adults Participants underwent guidance on received probiotic component containing different microbiological strains were followed for 60 days. Clinical parameters, body composition, biochemical analysis, assessment performed before after treatment. After days, it observed that bacterial present patients’ microbiota. also showed improvements physical activity, sleep quality, anxiety management, as well changes some eating such consumption processed foods significant increase water intake. Results: BMI, fasting glucose, insulin, HOMA-IR, LDL cholesterol, triglycerides observed, addition an HDL improvement bowel movement frequency, stool consistency. Analysis revealed microbial diversity better balance between phyla Firmicutes Bacteroidetes. Conclusions: related improving microbiota, dietary increased reduced anxiety, quality have significantly contributed loss physiological parameters individuals.

Language: Английский

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Acidipropionibacterium acidipropionici, a propionate-producing bacterium, contributes to GPR41 signaling and metabolic regulation in high-fat diet-induced obesity in mice

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 3, 2025

Obesity is a major healthcare problem worldwide and induced by excess energy intake, resulting in gut microbial composition diversity changes. Through fermentation of dietary fibers, short-chain fatty acids (SCFAs) act as host sources signaling molecules via G protein-coupled receptors such GPR41. Acidipropionibacterium acidipropionici widely used many applications; however, vivo studies on the beneficial effect A. propionate production homeostasis are unclear. Therefore, this study aimed to investigate metabolic effects focusing GPR41 high-fat diet (HFD)-induced obesity mouse model. Here, we demonstrated that OB7439 improved metabolism HFD-induced mice. The intake obese mice increasing production, regulating glucose tolerance, inhibiting hepatic inflammation signaling. Our findings shed light potential using an SCFA producer for prevention treatment disorders. Based these results, suggest may be therapeutic bacterium inhibits modulates community.

Language: Английский

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Strain-specific effects of probiotics on depression and anxiety: a meta-analysis

Gut Pathogens, Journal Year: 2024, Volume and Issue: 16(1)

Published: Sept. 8, 2024

Depression and anxiety are pervasive mental health disorders with substantial global burdens. Probiotics, live microorganisms known for their benefits, have emerged as a potential therapeutic intervention these conditions. This systematic review meta-analysis aim to evaluate the strain-specific effects of probiotics on relieving depressive symptoms while elucidating underlying mechanisms.

Language: Английский

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Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2671 - 2671

Published: Feb. 25, 2024

The prevalence and incidence of obesity the comorbidities linked to it are increasing worldwide. Current therapies for associated pathologies have proven cause a broad number adverse effects, often, they overpriced or not affordable all patients. Among alternatives currently available, natural bioactive compounds stand out. These frequently contained in pharmaceutical presentations, nutraceutical products, supplements, functional foods. clinical evidence these molecules is increasingly solid, among which epigallocatechin-3-gallate, ellagic acid, resveratrol, berberine, anthocyanins, probiotics, carotenoids, curcumin, silymarin, hydroxy citric α-lipoic acid molecular mechanisms signaling pathways been shown interact with endocrine, nervous, gastroenteric systems. They can regulate expression multiple genes proteins involved starvation–satiety processes, activate brown adipose tissue, decrease lipogenesis inflammation, increase lipolysis, improve insulin sensitivity. This review provides comprehensive view nature-based therapeutic options address obesity. It offers valuable perspective future research subsequent practice, addressing everything from molecular, genetic, physiological bases study compounds.

Language: Английский

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Stachyose ameliorates obesity-related metabolic syndrome via improving intestinal barrier function and remodeling gut microbiota

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 115, P. 106106 - 106106

Published: March 7, 2024

In this study, oral supplementation of stachyose significantly improved HFD-induced MetS symptom, including overweight, hyperlipidemia, hepatic steatosis and system-wide inflammation. The subsequent analysis revealed that supplement enhanced the integrity intestinal epithelial barrier effectively reversed gut microbiota dysbiosis, as evidenced by improvements in microbial gene richness, composition, functional characteristics. abundance butyrate-producing strains, such Bacteroides faecis, Butyomonas faecalis, Parabacteroides distasonis Phocaeicola coprophilus is increased, concurrently with activation PPAR-γ signaling pathway. findings our study suggest exhibits potential a prebiotic agent for prevention dysbiosis disruption obese. results demonstrates mitigating preserving individuals MetS.

Language: Английский

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Understanding the complex function of gut microbiota: its impact on the pathogenesis of obesity and beyond: a comprehensive review

Diabetology & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 16(1)

Published: Dec. 23, 2024

Obesity is a multifactorial condition influenced by genetic, environmental, and microbiome-related factors. The gut microbiome plays vital role in maintaining intestinal health, increasing mucus creation, helping the epithelium mend, regulating short-chain fatty acid (SCFA) production. These tasks are for managing metabolism energy balance. Dysbiosis—an imbalance microbiome—leads to increased appetite rise of metabolic disorders, both fuel obesity its issues. Furthermore, childhood connects with unique shifts microbiota makeup. For instance, there surge pro-inflammatory bacteria compared children who not obese. Considering intricate nature variety microbiota, additional investigations necessary clarify exact involvement beginnings advancement related dilemmas. Currently, therapeutic methods like probiotics, prebiotics, synbiotics, fecal transplantation (FMT), dietary interventions Mediterranean ketogenic diets, physical activity show potential adjusting fight aid weight loss. review underscores integration microbial metabolites pharmacological agents such as orlistat semaglutide restoring homeostasis. However, more clinical tests essential refine doses, frequency, lasting effectiveness these treatments. This narrative overview compiles existing knowledge on multifaceted much more, showcasing possible treatment strategies addressing health challenges.

Language: Английский

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Supplementation of mixed Lactobacillus alleviates metabolic impairment, inflammation, and dysbiosis of the gut microbiota in an obese mouse model

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 26, 2025

Introduction Obesity is a complex metabolic disease, which often accompanied with impaired glucose and lipid metabolism chronic inflammation. Probiotics have been considered as strategy for treating obesity, while the genus of Lactobacillus most commonly tested approved probiotics. Some multi-strain probiotics were proven to produce synergistic effects on obesity compared mono-strain ones. Methods The purpose this study was investigate anti-obesity effect new probiotic formation contained plantarum L14, paracasei L9, rhamnosus GG, sakei X-MRS-2, designated L-PPRS. Multi-strain L-PPRS shown better antiadipogenic than in 3T3-L1 cell. Subsequently, orally supplemented high-fat diet (HFD) induced obese mouse model two kinds treatment course, short-term (8 weeks) one long-term (12 one. Results We found that intervention not only significantly inhibited weight gain HFD-fed mice, but also improved tolerance, insulin sensitivity reduced serum levels. Furthermore, fat accumulation adipose tissue liver, ameliorated antioxidant capacity liver mice. modulated expression lipid-metabolic genes, exhibited excellent anti-inflammatory effect. In addition, restored dysbiosis gut microbiota via reducing Firmicutes/ Bacteroidetes ratio, increasing abundance beneficial intestinal bacteria. conclusion, proved could effectively prevent development its associated abnormalities, supplementation provided more profound benefit short-term. Discussion This highlights potential an effective strategy.

Language: Английский

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Progress in Probiotic Science: Prospects of Functional Probiotic‐Based Foods and Beverages

International Journal of Food Science, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

This comprehensive review explores the evolving role of probiotic‐based foods and beverages, highlighting their potential as functional “ future ” that could significantly enhance nutrition, health, overall well‐being. These products are gaining prominence for benefits in gut immune support, holistic wellness. However, success depends on addressing critical safety concerns navigating administrative complexities. Ensuring these do more good than harm involves rigorous evaluations probiotic strains, particularly those sourced from human gastrointestinal tract. Lactic acid bacteria (LABs) serve versatile effective starter cultures development beverages. The emphasizes LABs precision probiotics advancing products. Establishing standardized guidelines transparent practices is essential, requiring collaboration among regulatory bodies, industry stakeholders, scientific community. underscores importance innovation developing friendly ,” super fermentation, assessments. prospects beverages rely refining elements adapting to emerging advancements. Ultimately, empowering consumers with accurate information, fostering innovation, maintaining stringent standards will shape trusted beneficial components a health‐conscious society. Probiotic‐based often infused LABs, designed health.

Language: Английский

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Oral Administration of Alcohol-Tolerant Lactic Acid Bacteria Alleviates Blood Alcohol Concentration and Ethanol-Induced Liver Damage in Rodents

Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 34(4), P. 838 - 845

Published: Jan. 18, 2024

Language: Английский

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Anti-Obesity Properties of a Novel Probiotic Strain of Latilactobacillus sakei CNTA 173 in Caenorhabditis elegans

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3286 - 3286

Published: April 1, 2025

Probiotic strains with health-promoting activities have emerged as a promising strategy to prevent or treat different metabolic syndrome-related disturbances, including obesity type 2 diabetes. In this work, we characterize the probiotic properties of novel strain Latilactobacillus sakei (L. sakei) CNTA 173, and demonstrate its anti-obesity using in vivo model Caenorhabditis elegans (C. elegans). This new exhibited sensitivity entire spectrum antibiotics analysed, gastric intestinal vitro resistance, β-galactosidase activity, ability form biofilm produce acetic acid vitro. Cell culture analyses demonstrated that L. 173 was able reduce adhesion Caco-2 cells pathogenic E. coli O157:H7 exert immunomodulatory capacity RAW 264.7 HT-29 models. Furthermore, supplementation counteracted deleterious effects glucose C. by significantly reducing fat accumulation, enhancing oxidative stress response, extending lifespan directly regulating carbohydrate lipid metabolism-related genes acox-1, maoc-1, daf-16. Our results unveil strain-specific mechanisms action which exerts beneficial elegans, suggest potential application prevention treatment disturbances.

Language: Английский

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