Minerva Gastroenterology, Journal Year: 2024, Volume and Issue: 70(2)
Published: March 27, 2024
Eradication for Helicobacter pylori usually induces digestive dysbiosis that, in turn, elicits symptoms. Consequently, probiotic supplementation may counterbalance the disturbed microbiota after this procedure. So, probiotics restore homeostasis quickly relieve complaints.
Language: Английский
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102399 - 102399
Published: June 30, 2024
Language: Английский
Citations
10
Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 569 - 569
Published: Feb. 3, 2025
The muco-microbiotic layer represents a critical biological frontier in gastroenterology, emphasizing the intricate interplay between protective mucus, its resident microbiota, and extracellular vesicles. This review explores functional morphology of gastric mucosa, focusing on layer, role as barrier, dynamic interaction with some most insidious pathogens such Helicobacter pylori (H. pylori). Highlighting multifaceted mechanisms H. pathogenesis, we have delved into bacterial virulence factors, host immune responses, microbiota’s regulatory effects. Novel therapeutic strategies for eradication, including traditional antibiotic therapies emerging adjuvant treatments like probiotics probiotic-derived vesicles, are critically examined. These findings underscore potential targeting nanovesicular interactions proposing paradigm shift management infections to improve patient outcomes while mitigating resistance.
Language: Английский
Citations
2
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 27, 2025
Helicobacter pylori is a gram-negative microaerophilic microorganism intricately associated with chronic gastrointestinal disorders and gastric cancer. H. can cause various upper digestive tract diseases, including gastritis, peptic ulcer, gastroesophageal reflux disease, The bacterium exhibits variety of pathogenic mechanisms, colonization, the expression virulence factors, development drug resistance. This article presents comprehensive review pathogenesis, emphasizing recent research advancements concerning cytotoxin-associated gene A, vacuolating cytotoxin, outer membrane proteins, other factors. Additionally, it examines molecular mechanisms underlying resistance evaluates efficacy conventional therapeutic approaches. Recently, researchers have attempted novel regimens, probiotics Chinese medicine-assisted therapies, to enhance effects. aimed offer an overview academic community's comprehension infection highlight current treatment options.
Language: Английский
Citations
1
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 698 - 698
Published: May 28, 2024
Novel potassium-competitive acid blockers (P-CABs) have emerged as effective acid-suppressive drugs in recent years, replacing proton pump inhibitors (PPIs). We aim to compare the efficacy and safety of P-CABs versus PPIs treatment peptic ulcers with or without Helicobacter pylori (H. pylori) infection. searched PubMed, Embase, WOS, Cochrane Library, ClinicalTrials.gov, CNKI, Wanfang databases (all years up January 2024). Efficacy outcomes were evaluated using odds ratio (OR) 95% confidence intervals (CI). The Surface Under Cumulative Ranking (SUCRA) probabilities used rank each intervention. Among 14,056 studies screened, 56 involving 9792 participants analyzed. Vonoprazan demonstrated best ulcer healing rate H. eradication (SUCRA = 86.4% 90.7%, respectively). Keverprazan ranked second rates 76.0%) was more pain remission 91.7%). risk adverse events low for keverprazan 11.8%) tegoprazan 12.9%), moderate vonoprazan 44.3%) demonstrated. Compared lansoprazole, exhibited a higher drug-related (OR: 2.15; CI: 1.60–2.89) serious 2.22; 1.11–4.42). Subgroup analysis on patients pylori-positive showed that at top SUCRA rankings, followed by keverprazan. superior performance ulcers, especially ulcers. However, associated should be noted. has also shown good therapeutic performed better terms safety.
Language: Английский
Citations
6
European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177314 - 177314
Published: Feb. 1, 2025
Language: Английский
Citations
0
Medicina, Journal Year: 2025, Volume and Issue: 61(2), P. 346 - 346
Published: Feb. 16, 2025
Coronary artery disease (CAD) is one of the leading causes death worldwide, significantly contributing to mortality in both developed and developing nations. CAD arises from a combination risk factors, including atherosclerosis, dyslipidemia, hypertension, diabetes, smoking. In recent years, growing evidence has suggested potential link between infectious agents cardiovascular diseases. Among these, Helicobacter pylori (H. pylori) infection been hypothesized for over decade play role pathogenesis CAD. This hypothesis based on bacterium's ability trigger host inflammatory or autoimmune responses, potentially progression atherosclerotic plaques coronary events. The association H. considerable interest as it opens new avenues prevention management strategies health. Understanding this relationship could lead innovative approaches reducing burden CAD, particularly populations with high prevalence pylori. review, we aim provide comprehensive overview most involvement development prognosis By analyzing synthesizing current findings, seek shed light unresolved questions clarify ambiguous aspects connection. Our goal contribute deeper understanding how pylori, may influence inspire further research critical area.
Language: Английский
Citations
0
iLABMED, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
ABSTRACT Helicobacter pylori , a gram‐negative microaerophilic bacterium, is implicated in broad spectrum of upper gastrointestinal disorders, including chronic gastritis, peptic ulcers, gastric cancer, and even certain extragastric diseases. Its ability to colonize persist within the host driven by complex arsenal colonization virulence factors, underscoring intricate dynamics host–pathogen interactions. The clinical management H. remains challenging, primarily due absence commercially available vaccines increasing prevalence multidrug resistance. Accurate reliable detection methods are therefore critical for preventing infections, identifying antibiotic resistance, assessing treatment efficacy. Currently, both invasive non‐invasive diagnostic approaches employed, each with unique strengths limitations. This review provides comprehensive overview pathogenesis, strategies, therapeutic interventions, highlighting latest advancements technologies. By critically evaluating existing exploring innovative approaches, this aims support future progress effective globally prevalent pathogen.
Language: Английский
Citations
0
Polish Journal of Microbiology, Journal Year: 2025, Volume and Issue: 74(1), P. 60 - 70
Published: March 1, 2025
Abstract Infection with Helicobacter pylori is the major causative factor of chronic gastritis, peptic ulcer, gastric cancer, and other diseases. Gastric mucosal epithelial injury characterized by abnormal apoptosis, oxidative stress, inflammation a crucial mechanism H. infection. Hyperoside (HYP) flavonol glycoside derived from many herbal plants, which exhibits potent anti-apoptotic, antioxidant, anti-inflammatory properties. Our research explored whether it exerts protective effects on -infected human cells. GES-1 cells were first treated for 24 h HYP (0, 10, 20, 40, 80, 100, or 120 μM) to determine cytotoxicity HYP. Subsequently, pre-treated 4 (80 μM), followed exposure h. CCK-8 assay, flow cytometry ELISA, RT-qPCR, DCFH-DA staining, commercial assay kits, immunofluorescence western blotting used assess cell viability, pro-inflammatory cytokine levels, stress marker Nrf2/HO-1 signaling-related molecule levels. The Nrf2 inhibitor ML385 was employed verify beneficial role activation in HYP-mediated induced . results showed that pre-treatment reversed -induced inflammation, Furthermore, downregulated Nrf2, HO-1, NQO1 protein levels overturned against stress. In conclusion, protects activating pathway.
Language: Английский
Citations
0
Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(4)
Published: April 18, 2025
Helicobacter pylori (H. pylori) infection and atrial fibrillation (AF) are prevalent global health concerns that significantly impact societal economic well-being. This study explored the potential associations between H. incidence progression of AF. Emerging research suggests may influence AF through various pathways, including systemic inflammation, metabolic disturbances, immune responses, changes in gut microbiota. These pathways provide a novel perspective on etiology AF, suggesting chronic could exacerbate or even initiate arrhythmic events typical Current evidence, while preliminary, points to significant correlations, particularly markers such as C-reactive protein (CRP) lipid metabolism, which heightened individuals with active infection. However, exact mechanisms causal nature this relationship remain elusive, studies showing conflicting results. inconsistency underscores need for more comprehensive rigorously designed clinical experimental elucidate fully interactions Understanding these connections is crucial developing innovative treatments management strategies targeting microbial influences patients. Future should focus defining role eradication assessing its disease patient outcomes.
Language: Английский
Citations
0
European Journal of Clinical Microbiology & Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown
Published: May 14, 2025
Helicobacter pylori is an important pathogen responsible for various gastrointestinal disorders, including peptic ulcers and gastric cancer. Rapid accurate detection of H. infection crucial its early diagnosis treatment. This study aimed to develop evaluate the efficacy a colorimetric loop-mediated isothermal amplification (C-LAMP) assay in tissue biopsy samples. In total, 302 samples were collected, performance C-LAMP was compared with that conventional diagnostic methods, culture, PCR, rapid urease test (CLO test). The limit 1 CFU/mL reaction time 15 min at 61 °C, highlighting efficiency diagnosis. Compared demonstrated sensitivity 80% specificity 98%, whereas 60% 100%. ROC analysis revealed superior accuracy (AUC = 0.80 using PCR as reference; AUC 0.89 culture reference) relative CLO 0.63 vs. PCR; 0.65 culture), 0.60 PCR), 0.78 culture). These results suggest highly sensitive, specific, cost-effective tool pylori, offering significant advantages over particularly resource-limited settings, promising alternative reliable both clinical field settings.
Language: Английский
Citations
0