Emerging Perspectives: The Interplay of Taste Perception and Oral Microbiota Composition in Dietary Preferences and Obesity

Nutrition Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Oct. 21, 2024

Recent advancements in sensory research have brought to light the intricate relationship between taste perception and oral microbiota, prompting investigations into their influence on human health, particularly context of dietary preferences obesity. This review aims update current understanding how microbiota choices, elucidating shared metabolic pathways food processing bacteria. Further, this outlines mechanisms underlying perception, emphasising role receptors buds shaping experiences influenced by genetic environmental factors. Notably, we explore bidirectional sensitivity, highlighting potential impact microbial composition thresholds implications for habits health outcomes, such as obesity dental caries. However, significant gaps remain, molecular linking with well long-term effects microbiota-targeted interventions. Future should focus longitudinal studies experimental interventions these connections more deeply, offering insights strategies promoting healthier behaviours managing diet-related non-communicable diseases.

Language: Английский

Bidirectional causal relationships between the skin microbiome and psoriasis: Insights from Mendelian randomization analysis

Medicine, Journal Year: 2025, Volume and Issue: 104(10), P. e41736 - e41736

Published: March 7, 2025

Psoriasis is a chronic inflammatory skin disease affecting 2% of the global population. Recent research suggests microbiome plays critical role in psoriasis. Skin data were obtained from KORA FF4 study Germany, and psoriasis FinnGen genome-wide association summary statistics. Forward reverse 2-sample Mendelian randomization (MR) analyses conducted to assess causal relationships. MR analysis identified several microbial features as risk factors for psoriasis, including family Neisseriaceae sebaceous (OR = 1.036, 95% CI: 1.010-1.062, P .0054), ASV011 dry 1.024, 1.000-1.048, .0490), order Clostridiales moist 1.016, 1.000-1.032, .0449). Protective included ASV016 0.972, 0.949-0.994, .0136) ASV053 0.973, 0.954-0.992, .0054) skin. Reverse confirmed significant factor changes microbiome, with notable associations region asv002 1.266, 1.061-1.510, .027) genus: Haemophilus 1.364, 1.065-1.746, .013). This reveals bidirectional relationships between highlighting specific such potential factors. Further needed develop treatments that modulate improve outcomes.

Language: Английский

Streptococcal quorum sensing peptide CSP-7 contributes to muscle inflammation and wasting

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(4), P. 167094 - 167094

Published: Feb. 29, 2024

Language: Английский