Functional constipation in children and probiotics: A review DOI
И. Н. Захарова, I. V. Berezhnaya,

Viktoria D. Churilova

et al.

Pediatrics Consilium Medicum, Journal Year: 2024, Volume and Issue: 4, P. 396 - 403

Published: Dec. 15, 2024

Functional constipation (FC) is a common gastrointestinal (GI) disorder in children. In 25 % of patients, symptoms persist into adulthood. This condition not only complex medical problem but also associated with financial and economic distress. Initially, FC was considered an intestinal motility dysfunction without structural metabolic disorders. Pathophysiological mechanisms development include stress, nutritional characteristics, insufficient fluid intake, food allergy, dysbiosis, which determines the need for long-term therapy. However, 37% patients fully comply recommendations attending physician, indicates low adherence to treatment. Recent studies prove that motor disorders are interaction gut microbiota (GM) low-grade inflammation. Probiotics seen as key strategy eliminate dysfunction. The effectiveness probiotics based on their ability normalize GM composition, well correct pH colon, improving GI thereby reducing symptoms. researchers agree biological system plays central role developing organism, being fundamental part bidirectional functional axes. main regulating functioning given between microbial groups, forms potential. probiotic Lacticaseibacillus paracasei DG (LPDG) has unique regulate composition colonization through modulation activity. Studies showed LPDG maintain resistance, preventing epithelial permeability syndrome immunotropic effect, supporting use this pathogenetically method treating FC.

Language: Английский

Gut Microecological Prescription: A Novel Approach to Regulating Intestinal Micro-Ecological Balance DOI Creative Commons
Lingping Zhu, Xuefeng Yang

International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 603 - 626

Published: Feb. 1, 2025

Abstract: The intestinal microecology is comprises microorganisms and other components constituting the entire ecosystem, presenting characteristics of stability dynamic balance. Current research reveals microecological imbalances are related to various diseases. However, fundamental clinical applications have not been effectively integrated. Considering importance complexity regulating balance, this study provides an overview high-risk factors affecting detection methods. Moreover, it proposes definition imbalance definition, formulation, outcomes gut prescription facilitate its application in practice, thus promoting on improving quality life population. Keywords: microecology, risk, prescription, faecal microbiota transplantation

Language: Английский

Citations

1
Pelvic floor physical therapy for functional constipation in children: a systematic review and meta-analysis DOI
Jie Hao,

Andréas Remis,

Yaogeng Tang

et al.

Pediatric Surgery International, Journal Year: 2025, Volume and Issue: 41(1)

Published: April 26, 2025

Language: Английский

Citations

0
Pediatric Functional Constipation: A New Challenge DOI Creative Commons
Samina Khan Bashir, Muhammad Bashir Khan

Advanced Gut & Microbiome Research, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Functional constipation is a common gastrointestinal disorder worldwide in children, adolescents, and adults. persistent, difficult, infrequent hard stooling with incomplete rectal emptying that does not have an identifiable cause, such as underlying illness, anatomical abnormality, or medication, diagnosis of exclusion causes psychological physical symptoms the individual. For early identification functional physician must exclude organic children by history, examination, lab studies. Multiple complex pathophysiological mechanisms been linked to childhood constipation, which stool‐withholding behavior most factor. Toilet training along osmotic laxative use currently therapy for constipation. Despite being condition novel therapies prosecretory agents, neuromodulation, transanal irrigation modalities, it challenging sometimes manage children. This due lack knowledge among parents about nature poor adherence treatment ultimately worsen condition. The complaint child should be ignored evaluation beneficial child’s growth. More research needed prevent review article highlights factors responsible pediatric its management, therapies, challenges managing this

Language: Английский

Citations

3
Fructooligosaccharides for Relieving Functional Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials DOI Creative Commons
Hongmin Zhen, Hui Qian, Xiaoyan Liu

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 3993 - 3993

Published: Dec. 11, 2024

Fructooligosaccharides (FOS) are prebiotics with great potential to improve constipation. This study set out investigate the usefulness of consuming FOS as a dietary supplement on bowel movement frequency, stool consistency, abundance Bifidobacteria, gastrointestinal transit time, and symptoms through systematic review meta-analysis randomized controlled trials (RCTs). We searched Cochrane Library, PubMed, EMBASE, Web Science databases up 2 March 2024. Randomized reporting use by participants were included. Bias risk was assessed using Risk assessment tool. Results synthesized random-effects model or fixed-effects model, combining outcomes odds ratios (OR), weighted mean differences (MD), standardized (SMD) 95% confidence intervals (CI). The encompassed 17 trials, involving total 713 participants. Overall, intake significantly increased frequency (95% CI: 0.80, 1.50, p < 0.00001) positively affected softening (SMD: 0.36, 0.12, 0.60, = 0.76). It also reduced effort pain during defecation −0.60, −0.85, −0.34, 0.12). At same mild bloating noted an adverse event associated ingestion (OR: 10.36, 3.32, 33.23, 0.24). No reports serious events documented. may enhance overall constipation symptoms, suggesting cautious optimism regarding their treatment alternative. Nevertheless, further robust definitive required more accurately determine most effective dosage duration use. Additional research evidence necessary before efficacy therapeutic method for treating functional can be firmly established.

Language: Английский

Citations

0
Functional constipation in children and probiotics: A review DOI
И. Н. Захарова, I. V. Berezhnaya,

Viktoria D. Churilova

et al.

Pediatrics Consilium Medicum, Journal Year: 2024, Volume and Issue: 4, P. 396 - 403

Published: Dec. 15, 2024

Functional constipation (FC) is a common gastrointestinal (GI) disorder in children. In 25 % of patients, symptoms persist into adulthood. This condition not only complex medical problem but also associated with financial and economic distress. Initially, FC was considered an intestinal motility dysfunction without structural metabolic disorders. Pathophysiological mechanisms development include stress, nutritional characteristics, insufficient fluid intake, food allergy, dysbiosis, which determines the need for long-term therapy. However, 37% patients fully comply recommendations attending physician, indicates low adherence to treatment. Recent studies prove that motor disorders are interaction gut microbiota (GM) low-grade inflammation. Probiotics seen as key strategy eliminate dysfunction. The effectiveness probiotics based on their ability normalize GM composition, well correct pH colon, improving GI thereby reducing symptoms. researchers agree biological system plays central role developing organism, being fundamental part bidirectional functional axes. main regulating functioning given between microbial groups, forms potential. probiotic Lacticaseibacillus paracasei DG (LPDG) has unique regulate composition colonization through modulation activity. Studies showed LPDG maintain resistance, preventing epithelial permeability syndrome immunotropic effect, supporting use this pathogenetically method treating FC.

Language: Английский

Citations

0