Indian Journal of Microbiology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 13, 2024
Language: Английский
Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 341, P. 119342 - 119342
Published: Jan. 9, 2025
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1326 - 1326
Published: Feb. 4, 2025
Recurrent pregnancy loss (RPL) of unknown genesis is a complex condition with multifactorial origins, including genetic, hormonal, and immunological factors. However, the specific mechanisms underlying endocervical cell proliferation disorders in women RPL remain inadequately understood, particularly concerning role microbiota viral infections. The aim this study was to investigate by examining microbiota, human papillomavirus (HPV) typing, expression levels key molecular biological markers, p16/Ki-67, BCL-2, miR-145, miR-34a. A prospective observational comparative executed on healthy pregnant controls full ethical approval. Samples were collected for HPV typing immunocytochemical analysis evaluate p16, Ki-67, anti-oncogenic microRNAs (miR-145 miR-34a). mRNA progesterone receptor (PGR-A) also assessed, alongside local immune status proinflammatory T-lymphocytes (Th17/Th1) regulatory CD4+ Tregs. Overexpression BCL-2 observed 52.5% who had an ASC-US/LSIL cytogram, average double p16/Ki-67 being three times higher than group. significant decrease PGR-A endocervix noted, accompanied dysregulated characterized increased prevalence Th17/Th1 cells reduction Additionally, miR-145 miR-34a endometrium significantly differed from physiological group, context high-risk infection. findings describe that are associated overexpression impaired regulation, altered microRNA profiles. These alterations may contribute pathophysiology RPL, highlighting need further research into targeted interventions could improve reproductive outcomes affected individuals.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1424 - 1424
Published: Feb. 8, 2025
Human papillomavirus (HPV) is a leading cause of mucosal cancers, including the increasing incidence HPV-related head and neck cancers. The oral microbiota—a diverse community bacteria, fungi, viruses—play critical role in systemic health. Oral microbiota dysbiosis increasingly linked to inflammation, immune suppression, cancer progression. Recent studies have highlighted complex interaction between HPV microbiota, suggesting this interplay influences viral persistence, response tumor microenvironment. These interactions hold significant implications for disease progression, clinical outcomes, therapeutic approaches. Furthermore, has emerged as promising biomarker detection progress assessment. In addition, probiotic-based treatments are gaining attention an innovative approach preventing or treating cancers by modulating microbial environment. review, current research on provided, their explored, future potential utilizing diagnostic innovations HPV-associated discussed.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 12, 2025
Abstract Dental simulation head model laboratories are crucial for clinical training stomatological students, yet the maintenance of their dental unit waterlines (DUWLs) has been overlooked. This study investigated water contamination in DUWLs within these and proposed solutions. Water samples were collected from 12 chairs three at time points: beginning, middle, end semester. At start semester, severe was observed, with colony counts 11,586 $$\:\pm\:$$ 1715 CFU/ml high-speed handpieces 5375 874 ways syringes. As semester progressed, gradually decreased but remained above thresholds. Both 20 mg/L organochlorine disinfectant chlorine dioxide effective reducing bacterial below standard ranges days post-disinfection. Microbial diversity analysis revealed Proteobacteria Bacteroidota as dominant phyla, Ascomycota fungal phylum. Potentially pathogenic bacteria such Pseudomonas , Burkholderia-Caballeronia-Paraburkholderia Ralstonia Mycobacterium Legionella Paenibacillus Streptomyces Acinetobacter Prevotella well fungi like Fusarium Penicillium detected. Therefore, urgent attention is needed to address DUWL laboratories, it recommended disinfect using either or every days.
Language: Английский
Citations
0
Nigerian Postgraduate Medical Journal, Journal Year: 2025, Volume and Issue: 32(1), P. 1 - 13
Published: Jan. 1, 2025
Cervical cancer (CC) remains a significant global health challenge, with the interplay between microbiome and progression becoming increasingly evident. A comprehensive literature search was conducted across multiple databases, including Embase, NCBI, Google Scholar, Elsevier, Science Direct PubMed, utilising specific keywords such as ‘cervical cancer’, microbiome’, ‘vaginal ‘Human papillomavirus’, ‘nanoparticles’, ‘drug delivery’ ‘dysbiosis’. Studies published over past 15 years were reviewed. total of 400 articles identified 65 research finally included. This systematic approach relevant studies, enabling an in-depth analysis microbial species, Parabacteroides, Escherichia, Shigella, Gardnerella Fusobacterium which are recognised potential biomarkers for CC diagnosis progression. Dysbiosis is characterised by reduction in helpful bacteria proliferation harmful ones. It linked to chronic inflammation human papillomavirus infection, both facilitate Advanced nanotechnology presents innovative therapeutic options treatment, enhancing drug delivery systems targeting tumour cells more effectively. Moreover, incorporating nanocarriers into treatment regimens aims improve bioavailability efficacy existing therapies, potentially transforming clinical approaches management. review highlights dual role diagnostic prognostic biomarker elucidates optimising strategies, advocating further on interactions pathology.
Language: Английский
Citations
0
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1521 - 1521
Published: Feb. 24, 2025
Background/Objectives: Persistent high-risk human papillomavirus (HPV) infections are the leading cause of cervical cancer. Developing evidence suggests that cervicovaginal microbiome plays a significant role in modulating HPV persistence and progression to neoplasia. This review synthesizes current knowledge on interplay between local immunity infections, emphasizing microbial diversity, immune responses, potential therapeutic implications. Methods: A thorough literature was performed using Embase, PubMed, Scopus, Google Scholar, encompassing studies published 2000 2024. Studies examining composition microbiome, HPV-related outcomes were evaluated synthesized into comprehensive review. Results: Lactobacillus-dominant particularly with L. crispatus, creates protective environment through lactic acid production, maintenance low pH, anti-inflammatory modulation, facilitating clearance. Dysbiosis, often characterized by dominance iners overgrowth anaerobic bacteria, fosters chronic inflammation, cytokine imbalance, microenvironment conducive progression. Hormonal changes menopause exacerbate these shifts, increasing risk lesions. suggest profiles antimicrobial peptides significantly influence further infection outcomes. Conclusions: The is critical determinant outcomes, for enhance responses prevent Personalized microbiome-targeted therapies may offer novel avenue managing reducing cancer incidence.
Language: Английский
Citations
0
Expert Opinion on Biological Therapy, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
The microbiota composition in humans varies according to the anatomical site and is crucial for maintaining homeostasis an overall healthy state. Several gastrointestinal, vaginal, respiratory, skin diseases are associated with dysbiosis. Alternative therapies such as transplantation can help restore normal be implemented treat clinically relevant diseases. Current conducted clinical trials were included this review (after searching on MEDLINE database from years 2017 2025) fecal (FMT) against recurrent Clostridiodes difficile infection (rCDI) vaginal (VMT) bacterial vaginosis. Washed (WMT) live biotherapeutic products (LBPs) also reviewed. In microbiota-based therapy, selecting optimal donors a limitation. A stool or bank should overcome time-consuming expensive process of donor recruitment. Microbiota-based LBPs promising treatment alternatives rCDI other dysbiosis-associated Specific could engineered out fluids-derived strains achieve selection specific beneficial microorganisms Personalized treatments solutions diseases, which remains important necessity practice.
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: March 9, 2024
Evidence has revealed that DDOST plays an important role in cancer development and progression. However, there are no reports on functions of cervical tumorigenesis. Hence, we investigated the relationship with prognosis, mutation, promoter methylation, immune cell infiltration, drug sensitivity using bioinformatics techniques. Our results demonstrated was significantly upregulated a variety tumor types correlated poor including cancer. Cox regression analysis dissected high expression associated survival patients. Immune infiltration defined negatively CD8 T cells NK cells. Strikingly, to multiple drugs DDOST. Therefore, our findings uncovered could play essential microenvironment regulation cancer, which indicated be useful biomarker for prognosis potential therapeutic target treatment.
Language: Английский
Citations
0
Indian Journal of Microbiology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 13, 2024
Language: Английский
Citations
0