Possible immune mechanisms of gut microbiota and its metabolites in the occurrence and development of immune thrombocytopenia DOI Creative Commons

Gengda Zhu,

Lixiang Yan,

Lijun Fang

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 7, 2024

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by increased platelet destruction and impaired production, leading to elevated bleeding tendency. Recent studies have demonstrated important link between the gut microbiota onset progression of several immune diseases in humans, emphasizing that microbiota-derived metabolites play a non-negligible role diseases. The its metabolites, such as short-chain fatty acids, oxidized trimethylamine, tryptophan secondary bile acids lipopolysaccharides, can alter intestinal barrier permeability modulating cell differentiation cytokine secretion, which turn affects systemic function host. It therefore reasonable hypothesize ecological dysregulation may be entirely new factor triggering ITP. This article reviews potential immune-related mechanisms representative ITP, well influence leaky on development with view enriching theoretical system ITP-related microecology providing ideas for study

Language: Английский

Role of Trimethylamine N-Oxide in Heart Failure DOI Creative Commons

Lele Jing,

Honghong Zhang,

Qiannan Xiang

et al.

Reviews in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 25(7)

Published: July 2, 2024

Heart failure (HF) is a clinical syndrome characterizing by typical physical signs and symptomatology resulting from reduced cardiac output and/or intracardiac pressure at rest or under stress due to structural functional abnormalities of the heart. HF often final stage all cardiovascular diseases significant risk factor for sudden arrest, death, liver kidney failure. Current pharmacological treatments can only slow progression recurrence HF. With advancing research into gut microbiome its metabolites, one such trimethylamine N-oxide (TMAO)—has been implicated in advancement correlated with poor prognosis patients However, precise role TMAO has not yet clarified. This review highlights concludes available evidence potential mechanisms associated HF, hope contributing new insights diagnosis prevention

Language: Английский

Citations

5
Helicobacter mastomyrinus infection induces autoimmune hepatitis in mice DOI Creative Commons
Liqi Zhu, Yuanyuan Liang,

Linghan Yang

et al.

Journal of Translational Autoimmunity, Journal Year: 2025, Volume and Issue: unknown, P. 100275 - 100275

Published: Jan. 1, 2025

Language: Английский

Citations

0
System Overview from Physiological and Pathological Standpoints DOI
Gustavo Rodrigues Pedrino,

Luíza Toubas Chaul,

Virgínia Farias Alves

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Edible fungi polysaccharides modulate gut microbiota and lipid metabolism: A review DOI

Huanyi Xu,

Zhixiang Xue, Ping Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137427 - 137427

Published: Nov. 12, 2024

Language: Английский

Citations

1
Possible immune mechanisms of gut microbiota and its metabolites in the occurrence and development of immune thrombocytopenia DOI Creative Commons

Gengda Zhu,

Lixiang Yan,

Lijun Fang

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 7, 2024

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by increased platelet destruction and impaired production, leading to elevated bleeding tendency. Recent studies have demonstrated important link between the gut microbiota onset progression of several immune diseases in humans, emphasizing that microbiota-derived metabolites play a non-negligible role diseases. The its metabolites, such as short-chain fatty acids, oxidized trimethylamine, tryptophan secondary bile acids lipopolysaccharides, can alter intestinal barrier permeability modulating cell differentiation cytokine secretion, which turn affects systemic function host. It therefore reasonable hypothesize ecological dysregulation may be entirely new factor triggering ITP. This article reviews potential immune-related mechanisms representative ITP, well influence leaky on development with view enriching theoretical system ITP-related microecology providing ideas for study

Language: Английский

Citations

0