Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 21, 2025

Current evidence on the associations between insulin resistance (IR) and Helicobacter pylori (H. pylori) infection remains limited. This study aimed to investigate association non-insulin-based surrogate markers of IR, including triglyceride glucose (TyG) index, high-density lipoprotein cholesterol (TG/HDL-C) ratio, metabolic score for IR (METS-IR), H. in U.S. populations. cross-sectional involving 939 participants from National Health Nutrition Examination Survey (NHANES) 1999–2000. The three were respectively investigated using logistic regression model, restricted cubic spline (RCS) curve subgroup analysis. Three levels significantly elevated participants. There was a positive infection, even after adjusting potential confounding variables by different models. In analysis, adjusted more likely be observed female Non-Hispanic White. Additionally, RCS revealed linear correlation TyG index across all models, METS-IR Model 3. However, nonlinear TG/HDL-C ratio These findings suggest that positively associated with infection. may serve as indicators identifying risk Not applicable.

Language: Английский

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Kill Two Birds with One Stone? The Effect of Helicobacter pylori Eradication in Decreased Prevalence of Gastric Cancer and Colorectal Cancer

Cancers, Journal Year: 2024, Volume and Issue: 16(22), P. 3881 - 3881

Published: Nov. 20, 2024

The connection between microbial infections and tumor formation is notably exemplified by

Language: Английский

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Antibiotic-free responsive biomaterials for specific and targeted Helicobacter pylori eradication

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 708 - 729

Published: Jan. 25, 2025

Language: Английский

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Chronic Infection With Gastric Helicobacters Induces Hepatic Lesions in Mice

Helicobacter, Journal Year: 2025, Volume and Issue: 30(2)

Published: March 1, 2025

ABSTRACT Background Helicobacter pylori infection is one of the most prevalent chronic bacterial infections worldwide. This bacillus colonizes human stomach lifelong, where it induces gastritis, evolving in some cases to gastro‐duodenal ulcers, gastric adenocarcinoma, and mucosa‐associated lymphoid tissue lymphoma. H. has also been associated with extragastric diseases, clinical data have suggested a role liver pathogenesis. retrospective study evaluated consequences Helicobacters on pathogenesis mouse experimental model. Materials Methods C57BL6 mice were infected either felis ( n = 12) or five mouse‐adapted strains 77) for year. Uninfected used as negative controls 10). Histopathological analysis paraffin‐embedded sections was performed, scores determined double‐blind manner inflammation steatosis. Results Mice several developed more parenchymal steatosis, known precursor lesions carcinogenesis, compared non‐infected mice. The presence positively correlated detection mucosa, particularly metaplasia. Conclusion Chronic characterized by which may be severity histopathological lesions. Understanding infection's impact could fine help detect prevent emergence other digestive tract‐related diseases.

Language: Английский

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Pivotal role of Helicobacter pylori virulence genes in pathogenicity and vaccine development

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 6, 2025

One of the most prevalent human infections is Helicobacter pylori (H. pylori), which affects more than half global population. Although H. are widespread, only a minority individuals develop severe gastroduodenal disorders. The resistance to antibiotics has reached concerning levels, significantly impacting effectiveness treatment. Consequently, development vaccines targeting virulence factors may present viable alternative for treatment and prevention infections. This review aims provide comprehensive overview current understanding infection, with particular focus on its factors, pathophysiology, vaccination strategies. discusses various associated pylori, such as cytotoxin-associated gene A (cagA), vacuolating cytotoxin (vacA), outer membrane proteins (OMPs), neutrophil-activated protein (NAP), urease (ure), catalase. based these characteristics essential controlling infection ensuring long-lasting protection. Various strategies formulations have been tested in animal models; however, their reproducibility humans remain uncertain. Different types vaccines, including vector-based inactivated whole cells, genetically modified protein-based subunits, multiepitope nucleic acid (DNA) explored. While some demonstrated promising results murine models, limited number successfully humans. article provides thorough evaluation recent research genes methods, offering valuable insights future address this health challenge.

Language: Английский

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Relationship Between Human Microbiome and Helicobacter pylori

Microbiology Research, Journal Year: 2025, Volume and Issue: 16(1), P. 24 - 24

Published: Jan. 17, 2025

The enteric microbiota influences gene expression in the colonic epithelium. H. pylori (Helicobacter pylori) affects gastric growth factors, cytokines, and tumor cell markers, potentially benefiting host. interaction between human is complex but appears beneficial disease development. This publication discusses microbiota, microbiome, chronic colonization, bacterium’s role disease. interplay bacterium during infection also explored. gut has most abundant microbial community performs vital roles food digestion nutrient uptake, extraction of absorbable vitamins, inhibition pathogen colonization. Helicobacter a highly specialized pathogen, predominantly colonizing mucus layer, on or adherent to underlying epithelial surfaces. Many studies have suggested that microbiome related infection, some bacterial species can be used for detection diagnosis infection. Human genome analysis revolutionized our understanding intricate relationship humans their associated communities. integration data displayed promising capabilities occult detection, unveiling previously hidden pathologies providing opportunities early intervention. These groundbreaking discoveries paved way novel therapeutic strategies deeper comprehension interconnected nature overall health.

Language: Английский

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Hybrid Feature Extraction and Transfer Learning Approach for Multi-Class Histopathological Image Classification in Colorectal Cancer

Published: Jan. 1, 2025

Language: Английский

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Correlation Analysis of <i>Helicobacter </i><i>pylori</i> Infection, Inflammatory Indexes and Early Colorectal Cancer

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 2070 - 2078

Published: Jan. 1, 2025

Language: Английский

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Lactiplantibacillus plantarum ZJ316 Alleviates Helicobacter pylori-Induced Intestinal Inflammation by Sustaining Intestinal Homeostasis

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Language: Английский

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Helicobacter pylori and Colorectal Cancer: Meeting Sir Austin Bradford Hill's Causality Criteria

Helicobacter, Journal Year: 2025, Volume and Issue: 30(2)

Published: March 1, 2025

ABSTRACT Introduction Epidemiological and experimental studies have suggested that chronic H. pylori infection may be associated with colorectal cancer (CRC), a topic of growing interest. The Bradford‐Hill criteria are the mainstay epidemiological approach to causal inference. We aim evaluate evidence based on causality association between CRC. Methodology A literature review databases search: Pubmed, ScienceDirect, Embase, SciELO, Cochrane, Medline. There no limits in period. Information sources were coherent objectives set selected. Results Applying Bradford Hill criteria, we can conclude is positively current findings should stimulate future explain how interacts intestinal dysbiosis role eradication treatment prevention Conclusions reasonably meets for causality. Further required consolidate data generate strategies determine whether translates into decreased CRC incidence mortality large populations.

Language: Английский

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