Identifying key blood markers for bacteremia in elderly patients: insights into bacterial pathogens

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 16, 2025

This study aimed to assess the distribution of bacteremia pathogens in elderly patients, examine impact gender on pathogen distribution, and evaluate predictive value routine blood parameters for diagnosing bacteremia. A retrospective analysis was conducted 151 patients (≥60 years old) admitted Fuding Hospital, Fujian University Traditional Chinese Medicine between October 2022 June 2023. Comprehensive tests cultures were performed. The diagnostic efficacy parameters, including white cell (WBC), neutrophil-to-lymphocyte ratio (NLR), platelet-lymphocyte (PLR), red width (RDW), evaluated using receive operating characteristic (ROC) curve analysis. Patients categorized into either culture-positive group (82 cases) or culture-negative (69 according culture results. No significant differences age found groups. primary bacterial Escherichia coli, Klebsiella pneumoniae Streptococcus. Elderly female demonstrated a significantly higher positivity rate E. coli compared their male counterparts (P = 0.021). areas under ROC (AUC) four as follows: WBC, 0.851 (95% confidence interval (CI) 0.790 - 0.912); NLR, 0.919 CI 0.875 0.963); PLR, 0.609 0.518 0.700); RDW 0.626 0.563 0.717). identified predominant pathogenic microorganism causing elderly, with among patients. Routine (WBC, RDW) potential

Language: Английский

The Intersection of Trauma and Immunity: Immune Dysfunction Following Hemorrhage

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2889 - 2889

Published: Dec. 19, 2024

Hemorrhagic shock is caused by rapid loss of a significant blood volume, which leads to insufficient flow and oxygen delivery organs tissues, resulting in severe physiological derangements, organ failure, death. Physiologic derangements after hemorrhage are due large part the body’s strong inflammatory response, immune dysfunction, secondary complications such as chronic immunosuppression, increased susceptibility infection, coagulopathy, multiple unregulated inflammation. Immediate management hemorrhagic includes timely control source bleeding, restoring intravascular preferably with whole blood, prevention ischemia failure optimizing tissue oxygenation. However, currently, there no clinically effective treatments available that can stabilize response reinstate homeostatic conditions. In this review, we will discuss what known about immunologic dysfunction following potential therapeutic strategies.

Language: Английский