Gut microbiota predict retinopathy in patients with diabetes: A longitudinal cohort study

Applied Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 108(1)

Published: Oct. 28, 2024

The gut microbiota has emerged as an independent risk factor for diabetes and its complications. This research aimed to delve into the intricate relationship between microbiome diabetic retinopathy (DR) through a dual approach of cross-sectional prospective cohort studies. In our study investigation involving ninety-nine individuals with diabetes, distinct microbial signatures associated DR were identified. Specifically, profiling revealed decreased levels Butyricicoccus Ruminococcus torques group, alongside upregulated methanogenesis pathways among patients. These concurrently exhibited lower concentrations short-chain fatty acids in their plasma. Leveraging machine learning models, including random forest classifiers, we constructed panel genera genes that robustly differentiated cases. Importantly, these also demonstrated significant correlations dietary patterns molecular profiles peripheral blood mononuclear cells. Building upon findings, followed 62 patients over 2-year period assess predictive value markers. results underlined panel's efficacy predicting incidence. By stratifying based on metabolites identified phase, established associations reduced Butyricicoccus, plasma acetate, increased susceptibility DR. not only deepens understanding how influences but underscores potential markers early indicators disease risk. insights hold promise developing targeted interventions at mitigating impact • Microbial are differed without DR-related taxa linked habits transcriptomic Lower abundances acetate prospectively

Language: Английский

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Gut microbiome research: Revealing the pathological mechanisms and treatment strategies of type 2 diabetes

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Abstract The high prevalence and disability rate of type 2 diabetes (T2D) caused a huge social burden to the world. Currently, new mechanisms therapeutic approaches that may affect this disease are being sought. With in‐depth research on pathogenesis T2D growing advances in microbiome sequencing technology, association between gut microbiota has been confirmed. participates regulation inflammation, intestinal permeability, short‐chain fatty acid metabolism, branched‐chain amino metabolism bile thereby affecting host glucose lipid metabolism. Interventions focusing gaining traction as promising approach management. For example, dietary intervention, prebiotics probiotics, faecal transplant phage therapy. Meticulous experimental design choice analytical methods crucial for obtaining accurate meaningful results from studies. How choose different machine learning data analysis extremely critical achieve personalized precision medicine.

Language: Английский

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Harnessing the Power of the Gut Microbiome: A Review of Supplementation Therapies for Metabolic Syndrome

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Metabolic syndrome (MetS) is a complex condition characterized by abdominal obesity, insulin resistance, dyslipidemia, and hypertension, all of which increase the risk cardiovascular disease type 2 diabetes. The gut microbiome plays significant role in metabolic health, influencing digestion, immune function, energy metabolism. When microbiota becomes imbalanced due to poor diet antibiotic use, it can lead systemic inflammation, abnormal lipid metabolism, are central features MetS. This review explores connection between microbial imbalances MetS, focusing on impact health. Supplementation therapies targeting microbiome, such as probiotics, prebiotics, synbiotics, postbiotics, evaluated for their potential improve parameters MetS patients. These interventions hold promise enhancing sensitivity, reducing improving profiles. However, further research needed optimize these approaches managing Understanding how leverage could innovative, non-invasive treatments this growing global health concern.

Language: Английский

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Unravelling the Role of Gut and Oral Microbiota in the Pediatric Population with Type 1 Diabetes Mellitus

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10611 - 10611

Published: Oct. 2, 2024

Type 1 Diabetes Mellitus (T1DM) is a chronic autoimmune disease that results in the destruction of pancreatic β cells, leading to hyperglycaemia and need for lifelong insulin therapy. Although genetic predisposition environmental factors are considered key contributors T1DM, exact causes remain partially unclear. Recent evidence has focused on relationship between gut, oral cavity, immune regulation, systemic inflammation. In individuals with changes gut microbial composition commonly observed, indicating dysbiosis may contribute dysregulation. Gut can influence system through increased intestinal permeability, altered production short chain fatty acids (SCFAs), interactions mucosal system, potentially triggering response. Similarly, development inflammation thus progression T1DM. A comprehensive understanding these relationships essential identification biomarkers early diagnosis monitoring, as well therapies aimed at restoring balance. This review presents synthesis current research connection T1DM microbiome dysbiosis, focus microbiomes pediatric populations. It explores potential mechanisms by which contributes pathogenesis examines microbiome-based therapies, including probiotics, prebiotics, synbiotics, faecal microbiota transplantation (FMT). complex highlights longitudinal studies monitor over time, investigate causal specific species develop personalised medicine approaches.

Language: Английский

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Profiling the Gut Microbiome: Practice and Potential

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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