Intranasal administration of Clostridium butyricum and its derived extracellular vesicles alleviate LPS-induced acute lung injury DOI Creative Commons
Li Liu, Cihua Zheng, Zhenyang Xu

et al.

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

ABSTRACT Acute lung injury (ALI) is associated with high morbidity and mortality rates. However, its clinical treatment limited. Currently, the of diseases by regulating microbiota has become a research hotspot. In this study, we investigated protective effects intranasal administration Clostridium butyricum derived extracellular vesicles (EVs) against lipopolysaccharide (LPS)-induced ALI. The results demonstrated that compared LPS group, pre-treatment group C. EVs reduced expression pro-inflammatory cytokines alleviated symptoms in ALI mice inhibiting TLR4/MyD88 signaling pathway. Moreover, inhibited apoptosis-related proteins increased barrier proteins. Additionally, intervention changed composition pulmonary microbiota. At species level, significantly relative abundance Acinetobacter johnsonii , while reversed effect. conclusion, these data demonstrate can prevent LPS-induced reducing inflammation, apoptosis, improving function. regulated to alleviate IMPORTANCE disorder plays an important role progression acute (ALI). very few studies have been conducted treat modulating diversity were altered mice, but ecological balance was restored . study reported mechanism for These reveal importance disease. It provides new approach new-generation probiotics.

Language: Английский

The mechanisms of Mahuang decoction in treating COPD: Insights from network pharmacology and in vivo studies DOI Creative Commons
Quan Qiu,

Yaya Guo,

Liangping Li

et al.

Letters in Drug Design & Discovery, Journal Year: 2025, Volume and Issue: unknown, P. 100048 - 100048

Published: May 1, 2025

Language: Английский

Citations

0
Intranasal administration of Clostridium butyricum and its derived extracellular vesicles alleviate LPS-induced acute lung injury DOI Creative Commons
Li Liu, Cihua Zheng, Zhenyang Xu

et al.

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

ABSTRACT Acute lung injury (ALI) is associated with high morbidity and mortality rates. However, its clinical treatment limited. Currently, the of diseases by regulating microbiota has become a research hotspot. In this study, we investigated protective effects intranasal administration Clostridium butyricum derived extracellular vesicles (EVs) against lipopolysaccharide (LPS)-induced ALI. The results demonstrated that compared LPS group, pre-treatment group C. EVs reduced expression pro-inflammatory cytokines alleviated symptoms in ALI mice inhibiting TLR4/MyD88 signaling pathway. Moreover, inhibited apoptosis-related proteins increased barrier proteins. Additionally, intervention changed composition pulmonary microbiota. At species level, significantly relative abundance Acinetobacter johnsonii , while reversed effect. conclusion, these data demonstrate can prevent LPS-induced reducing inflammation, apoptosis, improving function. regulated to alleviate IMPORTANCE disorder plays an important role progression acute (ALI). very few studies have been conducted treat modulating diversity were altered mice, but ecological balance was restored . study reported mechanism for These reveal importance disease. It provides new approach new-generation probiotics.

Language: Английский

Citations

1